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FNTA(2-379) [cytosol]
Stable Identifier
R-HSA-2530516
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
FNTA, Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha ecNumber2.5.1.58/ecNumber ecNumber2.5.1.59/ecNumber, FNTA_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
Potential therapeutics for SARS (Homo sapiens)
FNTB inhibitors bind FNTA:FNTB (Homo sapiens)
FNTA:FNTB [cytosol] (Homo sapiens)
FNTA(2-379) [cytosol] (Homo sapiens)
FNTA:FNTB:FTase inhibitors [cytosol] (Homo sapiens)
FNTA:FNTB [cytosol] (Homo sapiens)
FNTA(2-379) [cytosol] (Homo sapiens)
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Apoptotic execution phase (Homo sapiens)
Apoptotic cleavage of cellular proteins (Homo sapiens)
Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha (Homo sapiens)
FNTA(2-379) [cytosol] (Homo sapiens)
Sensory Perception (Homo sapiens)
Visual phototransduction (Homo sapiens)
The phototransduction cascade (Homo sapiens)
Inactivation, recovery and regulation of the phototransduction cascade (Homo sapiens)
FNTA:FNTB transfers FARN to GNGT1 (Homo sapiens)
FNTA:FNTB [cytosol] (Homo sapiens)
FNTA(2-379) [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS processing (Homo sapiens)
FNTB inhibitors bind FNTA:FNTB (Homo sapiens)
FNTA:FNTB [cytosol] (Homo sapiens)
FNTA(2-379) [cytosol] (Homo sapiens)
FNTA:FNTB:FTase inhibitors [cytosol] (Homo sapiens)
FNTA:FNTB [cytosol] (Homo sapiens)
FNTA(2-379) [cytosol] (Homo sapiens)
pro-RAS proteins are farnesylated (Homo sapiens)
FNTA:FNTB [cytosol] (Homo sapiens)
FNTA(2-379) [cytosol] (Homo sapiens)
FNTA:FNTB:FTase inhibitors [cytosol] (Homo sapiens)
FNTA:FNTB [cytosol] (Homo sapiens)
FNTA(2-379) [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P49354 FNTA
Gene Names
FNTA
Chain
initiator methionine:, chain:2-379
Reference Genes
BioGPS Gene:2339 FNTA
COSMIC (genes):FNTA FNTA
CTD Gene:2339 FNTA
dbSNP Gene:2339 FNTA
ENSEMBL:ENSG00000168522 FNTA
HGNC:3782 FNTA
KEGG:hsa:2339 FNTA
Monarch:2339 FNTA
NCBI Gene:2339 FNTA
OMIM:134635 FNTA
UCSC:P49354 FNTA
Reference Transcript
RefSeq:NM_002027.2 FNTA
Other Identifiers
11756229_s_at
1499_at
16651283
16651285
16651287
16651289
16651293
16651295
16651297
16651299
16651301
16651319
16651321
16651323
17068609
17068634
1772_s_at
18670682
18670683
18670684
18670685
18670686
18670687
18670688
18670689
18670690
18670691
18670692
18670693
18670694
18670695
18670696
18670697
18670698
18670699
18670700
18670701
18670702
18670703
200090_PM_at
200090_at
209471_PM_s_at
209471_s_at
230808_PM_at
230808_at
2339
3096429
3096430
3096431
3096432
3096434
3096435
3096439
3096442
3096443
3096444
3096445
3096446
3096447
3096448
3096449
3096450
3096451
3096452
3096453
3096454
3096455
3096456
3096457
3096458
3096459
3096460
3096461
3096462
3096488
3096490
3096492
3096494
3096496
3096498
3096524
3096526
3096528
3096530
3096542
3096544
3316108
3343180
3343189
3480872
43175_at
7892585
7892668
7892669
7892802
7892917
7893320
7893442
7893552
7893726
7893806
7893947
7893974
7894212
7894351
7894386
7894515
7894948
7895282
7895357
7895729
7895755
7895766
7895810
7896041
8146268
A_14_P110051
A_23_P24926
A_24_P830025
GE57602
GE796449
GO:0003824
GO:0004659
GO:0004660
GO:0004661
GO:0004662
GO:0004663
GO:0005515
GO:0005737
GO:0005829
GO:0005875
GO:0005886
GO:0005953
GO:0005965
GO:0007167
GO:0007179
GO:0007528
GO:0008017
GO:0008092
GO:0008318
GO:0016740
GO:0018342
GO:0018343
GO:0018344
GO:0030971
GO:0034330
GO:0035022
GO:0043014
GO:0060090
GO:0071340
GO:0090044
GO:0090045
GO:0140096
GO:1904395
HMNXSV003041838
Hs.138381.1.A1_3p_x_at
Hs.19058.0.A1_3p_at
Hs.19058.0.A1_3p_x_at
ILMN_1721704
ILMN_1746494
ILMN_2374191
L00634_s_at
L10413_at
PH_hs_0017285
TC08001898.hg
TC08002599.hg
g292030_3p_a_at
Participates
as a component of
FNTA:FNTB [cytosol] (Homo sapiens)
as an input of
Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha (Homo sapiens)
Other forms of this molecule
FNTA(59-379) [cytosol]
FNTA(1-59) [cytosol]
Inferred To
fnta [cytosol]
(Danio rerio)
fnta [cytosol]
(Xenopus tropicalis)
FNTA(2-379) [cytosol]
(Gallus gallus)
FNTA(2-379) [cytosol]
(Plasmodium falciparum)
fnta-1 [cytosol]
(Caenorhabditis elegans)
FNTA [cytosol]
(Bos taurus)
RAM2 [cytosol]
(Saccharomyces cerevisiae)
cwp1 [cytosol]
(Schizosaccharomyces pombe)
fntA [cytosol]
(Dictyostelium discoideum)
Fnta [cytosol]
(Drosophila melanogaster)
Fnta [cytosol]
(Mus musculus)
Fnta [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_002018.1
Guide to Pharmacology - Targets
2825
ENSEMBL
ENSP00000303423
,
ENST00000302279
OpenTargets
ENSG00000168522
HPA
ENSG00000168522-FNTA
PRO
P49354
Pharos - Targets
P49354
HMDB Protein
HMDBP01824
PDB
2H6G
,
2H6F
,
1MZC
,
1JCQ
,
2H6H
,
2H6I
,
1SA4
,
1TN6
,
3E37
,
1LD8
,
1LD7
,
2IEJ
,
2F0Y
,
1S63
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P49356 FNTB
1
FNTB [cytosol]
(R-HSA-2530482)
0.955
16
UniProt:P53609 PGTB1
0.742
10
UniProt:Q13627 DYRK1A
1
DYRK1A [nucleoplasm]
(R-HSA-1362267)
0.725
5
UniProt:Q12974 PTP4A2
1
FarC-PTP4A2 [cytosol]
(R-HSA-8870421)
0.564
2
UniProt:O00189 AP4M1
2
AP4M1 [endosome lumen]
(R-HSA-5229114)
AP4M1 [trans-Golgi network membrane]
(R-HSA-5215984)
0.556
3
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