Nicotinate metabolism

Stable Identifier
R-HSA-196807
Type
Pathway
Species
Homo sapiens
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Nicotinate metabolism
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Nicotinate (niacin) and nicotinamide are precursors of the coenzymes nicotinamide-adenine dinucleotide (NAD+) and nicotinamide-adenine dinucleotide phosphate (NADP+). When NAD+ and NADP+ are interchanged in a reaction with their reduced forms, NADH and NADPH respectively, they are important cofactors in several hundred redox reactions. Nicotinate is synthesized from 2-amino-3-carboxymuconate semialdehyde, an intermediate in the catabolism of the essential amino acid tryptophan (Magni et al. 2004).

Literature References
PubMed ID Title Journal Year
14704851 Enzymology of NAD+ homeostasis in man

Magni, G, Amici, A, Emanuelli, M, Orsomando, G, Raffaelli, N, Ruggieri, S

Cell Mol Life Sci 2004
Participants
Events
Participant Of
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Event Information
Go Biological Process
NAD metabolic process (0019674)
Orthologous Events
Nicotinate metabolism (Bos taurus)
Nicotinate metabolism (Caenorhabditis elegans)
Nicotinate metabolism (Canis familiaris)
Nicotinate metabolism (Danio rerio)
Nicotinate metabolism (Dictyostelium discoideum)
Nicotinate metabolism (Drosophila melanogaster)
Nicotinate metabolism (Gallus gallus)
Nicotinate metabolism (Mus musculus)
Nicotinate metabolism (Plasmodium falciparum)
Nicotinate metabolism (Rattus norvegicus)
Nicotinate metabolism (Saccharomyces cerevisiae)
Nicotinate metabolism (Schizosaccharomyces pombe)
Nicotinate metabolism (Sus scrofa)
Nicotinate metabolism (Xenopus tropicalis)
Authored
Jassal, B  (2007-04-24)
Created
Jassal, B  (2007-04-24)