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Nicotinate metabolism
Stable Identifier
R-HSA-196807
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of water-soluble vitamins and cofactors (Homo sapiens)
Nicotinate metabolism (Homo sapiens)
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Nicotinate (niacin) and nicotinamide are precursors of the coenzymes nicotinamide-adenine dinucleotide (NAD+) and nicotinamide-adenine dinucleotide phosphate (NADP+). When NAD+ and NADP+ are interchanged in a reaction with their reduced forms, NADH and NADPH respectively, they are important cofactors in several hundred redox reactions. Nicotinate is synthesized from 2-amino-3-carboxymuconate semialdehyde, an intermediate in the catabolism of the essential amino acid tryptophan (Magni et al. 2004).
Literature References
PubMed ID
Title
Journal
Year
14704851
Enzymology of NAD+ homeostasis in man
Ruggieri, S
,
Magni, G
,
Amici, A
,
Orsomando, G
,
Emanuelli, M
,
Raffaelli, N
Cell Mol Life Sci
2004
Participants
Events
ACS transforms to QUIN non-enzymatically
(Homo sapiens)
QPRT transfers PRIB to QUIN to form NAMN
(Homo sapiens)
NMRK1 phosphorylates NAR to yield NAMN
(Homo sapiens)
NMRK2 phosphorylates NAR to yield NAMN
(Homo sapiens)
NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD
(Homo sapiens)
NADSYN1 hexamer amidates NAAD to NAD+
(Homo sapiens)
NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+
(Homo sapiens)
NMRK1 phosphorylates NR to yield NMN
(Homo sapiens)
NMRK2 phosphorylates NR to yield NMN
(Homo sapiens)
NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+
(Homo sapiens)
NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD
(Homo sapiens)
NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD
(Homo sapiens)
NT5E:Zn2+ hydrolyses NAD+
(Homo sapiens)
NT5E:Zn2+ hydrolyses NMN
(Homo sapiens)
BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose
(Homo sapiens)
CD38 hydrolyses NAD+ to NAM and ADP-ribose
(Homo sapiens)
NADK2 dimer phosphorylates NAD+ to NADP+
(Homo sapiens)
Nicotinamide salvaging
(Homo sapiens)
Participates
as an event of
Metabolism of water-soluble vitamins and cofactors (Homo sapiens)
Event Information
Go Biological Process
NAD metabolic process (0019674)
Orthologous Events
Nicotinate metabolism (Bos taurus)
Nicotinate metabolism (Caenorhabditis elegans)
Nicotinate metabolism (Canis familiaris)
Nicotinate metabolism (Danio rerio)
Nicotinate metabolism (Dictyostelium discoideum)
Nicotinate metabolism (Drosophila melanogaster)
Nicotinate metabolism (Gallus gallus)
Nicotinate metabolism (Mus musculus)
Nicotinate metabolism (Plasmodium falciparum)
Nicotinate metabolism (Rattus norvegicus)
Nicotinate metabolism (Saccharomyces cerevisiae)
Nicotinate metabolism (Schizosaccharomyces pombe)
Nicotinate metabolism (Sus scrofa)
Nicotinate metabolism (Xenopus tropicalis)
Authored
Jassal, B (2007-04-24)
Created
Jassal, B (2007-04-24)
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