Reactome | CD38 hydrolyses NAD+ to NAM and ADP-ribose

CD38 hydrolyses NAD+ to NAM and ADP-ribose

Stable Identifier

R-HSA-8938076

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Synonyms

NAD(+) + H2O => ADP-D-ribose + nicotinamide + H(+)

ReviewStatus

5/5

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CD38 hydrolyses NAD+ to NAM and ADP-ribose

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ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38) is a multifunctional enzyme that can catalyse the hydrolysis of NAD+ to form linear ADP-ribose (ADP-D-ribose) and/or cyclization of NAD+ forming cyclic ADP-ribose (cADPR) via a two-step enzymatic reaction. The first common step involves the cleavage of the nicotinamide group of NAD+. The reaction intermediate can either be hydrolysed to form ADP-D-ribose or cyclized to form cADPR (Lee et al. 1995, Moreschi et al. 2006). CD38 can also produce nicotinic acid adenine dinucleotide phosphate (NAADP) (Lee et al. 1999). Both cADPR and NAADP are established second messengers for mobilising intracellular Ca2+ stores (Lee 2012). The reaction annotated here describes the hydrolysis of NAD+ to form ADP-D-ribose.

Literature References

PubMed ID	Title	Journal	Year
22822066	Cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate (NAADP) as messengers for calcium mobilization Lee, HC	J. Biol. Chem.	2012
10331643	Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes Graeff, R, Lee, HC, Munshi, C	Mol. Cell. Biochem.	1999
8527488	Cyclic ADP-ribose and its metabolic enzymes Graeff, R, Walseth, TF, Lee, HC	Biochimie	1995
16690024	NAADP+ synthesis from cADPRP and nicotinic acid by ADP-ribosyl cyclases Moreschi, I, Zocchi, E, Melone, L, Bruzzone, S, De Flora, A	Biochem. Biophys. Res. Commun.	2006