SLC22A13 transports NCA from extracellular region to cytosol

Stable Identifier
R-HSA-8869603
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region, cytosol
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SLC22A13 transports NCA from extracellular region to cytosol
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Plasma membrane-associated SLC22A13 (solute carrier family 22 member 13, also known as OCTL3 - organic cation transporter-like 3) mediates the uptake of extracellular nicotinate (NCA). The protein is especially abundant in the kidney but is widely expressed in tissues of the body (Bahn et al. 2008).

Literature References
PubMed ID Title Journal Year
18411268 Identification of a new urate and high affinity nicotinate transporter, hOAT10 (SLC22A13)

Bahn, A, Hagos, Y, Reuter, S, Balen, D, Brzica, H, Krick, W, Burckhardt, BC, Sabolic, I, Burckhardt, G

J. Biol. Chem. 2008
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
nicotinate transmembrane transporter activity of SLC22A13 [plasma membrane]
Physical Entity
SLC22A13 [plasma membrane]
Activity
nicotinate transmembrane transporter activity (0090416)
Orthologous Events
SLC22A13 transports NCA from extracellular region to cytosol (Bos taurus)
SLC22A13 transports NCA from extracellular region to cytosol (Caenorhabditis elegans)
SLC22A13 transports NCA from extracellular region to cytosol (Canis familiaris)
SLC22A13 transports NCA from extracellular region to cytosol (Danio rerio)
SLC22A13 transports NCA from extracellular region to cytosol (Drosophila melanogaster)
SLC22A13 transports NCA from extracellular region to cytosol (Gallus gallus)
SLC22A13 transports NCA from extracellular region to cytosol (Mus musculus)
SLC22A13 transports NCA from extracellular region to cytosol (Plasmodium falciparum)
SLC22A13 transports NCA from extracellular region to cytosol (Rattus norvegicus)
SLC22A13 transports NCA from extracellular region to cytosol (Sus scrofa)
SLC22A13 transports NCA from extracellular region to cytosol (Xenopus tropicalis)
Authored
D'Eustachio, P  (2016-05-06)
Reviewed
D'Eustachio, P  (2016-10-11)
Created
D'Eustachio, P  (2016-05-06)