BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose

Stable Identifier
R-HSA-8870346
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
Synonyms
NAD(+) + H2O => NAM + ADP-ribose + H+
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

BST1 dimer associated with the plasma membrane catalyzes the hydrolysis of extracellular NAD+ to yield NAM and ADP-ribose (Yamamoto-Katayama et al. 2002).

Literature References
PubMed ID Title Journal Year
11866528 Crystallographic studies on human BST-1/CD157 with ADP-ribosyl cyclase and NAD glycohydrolase activities

Ariyoshi, M, Ishihara, K, Hirano, T, Yamamoto-Katayama, S, Jingami, H, Morikawa, K

J. Mol. Biol. 2002
Participants
Input
Output
Participates
as an event of
Catalyst Activity

NAD+ nucleosidase activity of BST1 dimer [plasma membrane]

Physical Entity
BST1 dimer [plasma membrane] (Homo sapiens)
Activity
NAD+ nucleosidase activity (GO:0003953)
Orthologous Events
BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Bos taurus)
BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Canis familiaris)
BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Danio rerio)
BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Gallus gallus)
BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Mus musculus)
BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Rattus norvegicus)
BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Sus scrofa)
BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Xenopus tropicalis)
Cross References
Rhea
Authored
D'Eustachio, P  (2016-05-06)
Reviewed
D'Eustachio, P  (2016-10-11)
Created
D'Eustachio, P  (2016-05-09)
Cite Us!