BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose

Stable Identifier
R-HSA-8870346
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
Synonyms
NAD(+) + H2O => NAM + ADP-ribose + H+
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BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose
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BST1 dimer associated with the plasma membrane catalyzes the hydrolysis of extracellular NAD+ to yield NAM and ADP-ribose (Yamamoto-Katayama et al. 2002).

Literature References
PubMed ID Title Journal Year
11866528 Crystallographic studies on human BST-1/CD157 with ADP-ribosyl cyclase and NAD glycohydrolase activities

Yamamoto-Katayama, S, Ariyoshi, M, Ishihara, K, Hirano, T, Jingami, H, Morikawa, K

J. Mol. Biol. 2002
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
NAD+ nucleosidase activity of BST1 dimer [plasma membrane]
Physical Entity
BST1 dimer [plasma membrane]
Activity
NAD+ nucleosidase activity (0003953)
Orthologous Events
BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Bos taurus)
BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Canis familiaris)
BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Gallus gallus)
BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Mus musculus)
BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Rattus norvegicus)
BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Sus scrofa)
BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Xenopus tropicalis)
Cross References
Rhea
Authored
D'Eustachio, P  (2016-05-06)
Reviewed
D'Eustachio, P  (2016-10-11)
Created
D'Eustachio, P  (2016-05-09)