BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose

Stable Identifier
R-HSA-8870346
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
Synonyms
NAD(+) + H2O => ADP-D-ribose + nicotinamide + H(+)
ReviewStatus
5/5
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BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose
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BST1 dimer associated with the plasma membrane catalyzes the hydrolysis of extracellular NAD+ to yield NAM and ADP-ribose (Yamamoto-Katayama et al. 2002).
Literature References
PubMed ID Title Journal Year
11866528 Crystallographic studies on human BST-1/CD157 with ADP-ribosyl cyclase and NAD glycohydrolase activities

Ariyoshi, M, Ishihara, K, Hirano, T, Yamamoto-Katayama, S, Jingami, H, Morikawa, K

J. Mol. Biol. 2002
Participants
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Output
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as an event of
Catalyst Activity

NAD+ nucleosidase activity, cyclic ADP-ribose generating of BST1 dimer [plasma membrane]

Physical Entity
BST1 dimer [plasma membrane] (Homo sapiens)
Activity
NAD+ nucleosidase activity, cyclic ADP-ribose generating (GO:0061809)
Orthologous Events
BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Bos taurus)
BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Canis familiaris)
BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Gallus gallus)
BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Mus musculus)
BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Rattus norvegicus)
BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Sus scrofa)
BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Xenopus tropicalis)
Cross References
RHEA
Rhea
Authored
D'Eustachio, P  (2016-05-06)
Reviewed
D'Eustachio, P  (2016-10-11)
Created
D'Eustachio, P  (2016-05-09)
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