NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+

Stable Identifier
R-HSA-197198
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
NAD+ is phosphorylated to NADP+
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Cytosolic NAD+ kinase (NADK) catalyses the transfer of a phosphate group from ATP to NAD+, forming NADP+. This is the only way to generate NADP+ in all living organisms. NADK is tetrameric and requires one divalent metal such as Zn2+ per subunit to function correctly (Lerner et al. 2004).

Literature References
PubMed ID Title Journal Year
11594753 Structural and functional characterization of human NAD kinase

Lerner, F, Niere, M, Ludwig, A, Ziegler, M

Biochem Biophys Res Commun 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
NAD+ kinase activity of NADK:Zn2+ tetramer [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Created