NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+

Stable Identifier
R-HSA-197198
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
NAD+ is phosphorylated to NADP+
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Cytosolic NAD+ kinase (NADK) catalyses the transfer of a phosphate group from ATP to NAD+, forming NADP+. This is the only way to generate NADP+ in all living organisms. NADK is tetrameric and requires one divalent metal such as Zn2+ per subunit to function correctly (Lerner et al. 2004).

Literature References
PubMed ID Title Journal Year
11594753 Structural and functional characterization of human NAD kinase

Ziegler, M, Lerner, F, Ludwig, A, Niere, M

Biochem Biophys Res Commun 2001
Participants
Participates
Catalyst Activity

NAD+ kinase activity of NADK:Zn2+ tetramer [cytosol]

Orthologous Events
Cross References
Rhea
Authored
Created
Cite Us!