The human nudix hydrolase peroxisomal NADH pyrophosphatase (NUDT12) shows in vitro hydrolase activity towards NAD(P)H, NAD(P)+, ADP-ribose and diadenosine triphosphate. Like other NADH diphosphatases of the Nudix family, NUDT12 has a marked substrate preference for reduced nicotinamide nucleotides. It can hydrolyse NAD(H) to the nicotinamide mononucleotide NMN(H) and may act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism here (Abdelraheim et al. 2003).
Spiller, DG, Abdelraheim, SR, McLennan, AG
NADH pyrophosphatase activity of NUDT12 [peroxisomal matrix]
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