Reactome | NUDT12 hydrolyses NADH to NMNH

NUDT12 hydrolyses NADH to NMNH

Stable Identifier

R-HSA-6809287

Type

Reaction [transition]

Species

Homo sapiens

Compartment

peroxisomal matrix

ReviewStatus

5/5

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The human nudix hydrolase peroxisomal NADH pyrophosphatase (NUDT12) shows in vitro hydrolase activity towards NAD(P)H, NAD(P)+, ADP-ribose and diadenosine triphosphate. Like other NADH diphosphatases of the Nudix family, NUDT12 has a marked substrate preference for reduced nicotinamide nucleotides. It can hydrolyse NAD(H) to the nicotinamide mononucleotide NMN(H) and may act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism here (Abdelraheim et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
12790796	Mammalian NADH diphosphatases of the Nudix family: cloning and characterization of the human peroxisomal NUDT12 protein Spiller, DG, Abdelraheim, SR, McLennan, AG	Biochem. J.	2003