NUDT12 hydrolyses NADH to NMNH

Stable Identifier
R-HSA-6809287
Type
Reaction
Species
Homo sapiens
Compartment
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The human nudix hydrolase peroxisomal NADH pyrophosphatase (NUDT12) shows in vitro hydrolase activity towards NAD(P)H, NAD(P)+, ADP-ribose and diadenosine triphosphate. Like other NADH diphosphatases of the Nudix family, NUDT12 has a marked substrate preference for reduced nicotinamide nucleotides. It can hydrolyse NAD(H) to the nicotinamide mononucleotide NMN(H) and may act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism here (Abdelraheim et al. 2003).

Literature References
PubMed ID Title Journal Year
12790796 Mammalian NADH diphosphatases of the Nudix family: cloning and characterization of the human peroxisomal NUDT12 protein

Spiller, DG, Abdelraheim, SR, McLennan, AG

Biochem. J. 2003
Participants
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Catalyst Activity

NADH pyrophosphatase activity of NUDT12 [peroxisomal matrix]

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