NUDT12 hydrolyses NADH to NMNH

Stable Identifier
R-HSA-6809287
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The human nudix hydrolase peroxisomal NADH pyrophosphatase (NUDT12) shows in vitro hydrolase activity towards NAD(P)H, NAD(P)+, ADP-ribose and diadenosine triphosphate. Like other NADH diphosphatases of the Nudix family, NUDT12 has a marked substrate preference for reduced nicotinamide nucleotides. It can hydrolyse NAD(H) to the nicotinamide mononucleotide NMN(H) and may act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism here (Abdelraheim et al. 2003).

Literature References
PubMed ID Title Journal Year
12790796 Mammalian NADH diphosphatases of the Nudix family: cloning and characterization of the human peroxisomal NUDT12 protein

Abdelraheim, SR, Spiller, DG, McLennan, AG

Biochem. J. 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
NADH pyrophosphatase activity of NUDT12 [peroxisomal matrix]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created