Reactome | APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX

APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX

Stable Identifier

R-HSA-6806966

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix

ReviewStatus

5/5

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APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX

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NAD(P)H-hydrate epimerase (APOA1BP) is a homodimeric protein located in the mitochondrion (Ritter et al. 2002). Mammalian APOA1BP is able to mediate the epimerisation of the R-form of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (Marbaix et al. 2011). This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.

Literature References

PubMed ID	Title	Journal	Year
21994945	Extremely conserved ATP- or ADP-dependent enzymatic system for nicotinamide nucleotide repair Linster, CL, Vertommen, D, Noel, G, Detroux, AM, Van Schaftingen, E, Marbaix, AY	J. Biol. Chem.	2011
11991719	Cloning and characterization of a novel apolipoprotein A-I binding protein, AI-BP, secreted by cells of the kidney proximal tubules in response to HDL or ApoA-I Schmitz, G, Schmitz-Madry, A, Boettcher, A, Orsó, E, Fricker, G, Ritter, M, Schmiedeknecht, G, Bared, SM, Barlage, S, Baehr, CH, Buechler, C	Genomics	2002