NMRK2 phosphorylates NAR to yield NAMN

Stable Identifier
R-HSA-8869607
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
NAR + ATP(4-) => NAMN + ADP(3-) + H+
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NMRK2 (nicotinamide riboside kinase 2) catalyzes the reaction of NAR (N-ribosylnicotinate) and ATP to yield NAMN (beta-nicotinate D-ribonucleotide), ADP, and H+ (Tempel et al. 2007). The reaction is annotated with ATP(4-), the major ionized form of ATP at pH 7.2 (Stockbridge & Wolfenden 2009), as the phosphate donor. NMRK2 is a cytosolic enzyme (Nikiforov et al. 2011), localized predominantly in myocytes (Li et al. 1999).

Literature References
PubMed ID Title Journal Year
21504897 Pathways and subcellular compartmentation of NAD biosynthesis in human cells: from entry of extracellular precursors to mitochondrial NAD generation

Ziegler, M, Nikiforov, A, Dölle, C, Niere, M

J. Biol. Chem. 2011
17914902 Nicotinamide riboside kinase structures reveal new pathways to NAD+

Sauve, AA, Park, HW, Yang, T, Belenky, P, Seidle, HF, Tempel, W, Nedyalkova, L, Wojcik, M, Rabeh, WM, Bogan, KL, Brenner, C

PLoS Biol. 2007
10613898 A novel muscle-specific beta 1 integrin binding protein (MIBP) that modulates myogenic differentiation

Mayne, R, Wu, C, Li, J

J. Cell Biol. 1999
19531469 The intrinsic reactivity of ATP and the catalytic proficiencies of kinases acting on glucose, N-acetylgalactosamine, and homoserine: a thermodynamic analysis

Wolfenden, R, Stockbridge, RB

J. Biol. Chem. 2009
Participants
Participates
Catalyst Activity

ribosylnicotinate kinase activity of NMRK2 [cytosol]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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