NMRK2 phosphorylates NAR to yield NAMN

Stable Identifier
Reaction [transition]
Homo sapiens
NAR + ATP(4-) => NAMN + ADP(3-) + H+
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NMRK2 (nicotinamide riboside kinase 2) catalyzes the reaction of NAR (N-ribosylnicotinate) and ATP to yield NAMN (beta-nicotinate D-ribonucleotide), ADP, and H+ (Tempel et al. 2007). The reaction is annotated with ATP(4-), the major ionized form of ATP at pH 7.2 (Stockbridge & Wolfenden 2009), as the phosphate donor. NMRK2 is a cytosolic enzyme (Nikiforov et al. 2011), localized predominantly in myocytes (Li et al. 1999).

Literature References
PubMed ID Title Journal Year
17914902 Nicotinamide riboside kinase structures reveal new pathways to NAD+

Tempel, W, Rabeh, WM, Bogan, KL, Belenky, P, Wojcik, M, Seidle, HF, Nedyalkova, L, Yang, T, Sauve, AA, Park, HW, Brenner, C

PLoS Biol. 2007
21504897 Pathways and subcellular compartmentation of NAD biosynthesis in human cells: from entry of extracellular precursors to mitochondrial NAD generation

Nikiforov, A, Dölle, C, Niere, M, Ziegler, M

J. Biol. Chem. 2011
10613898 A novel muscle-specific beta 1 integrin binding protein (MIBP) that modulates myogenic differentiation

Li, J, Mayne, R, Wu, C

J. Cell Biol. 1999
19531469 The intrinsic reactivity of ATP and the catalytic proficiencies of kinases acting on glucose, N-acetylgalactosamine, and homoserine: a thermodynamic analysis

Stockbridge, RB, Wolfenden, R

J. Biol. Chem. 2009
Participant Of
Catalyst Activity
Catalyst Activity
ribosylnicotinate kinase activity of NMRK2 [cytosol]
Physical Entity
Orthologous Events
Cross References
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