SLC5A8 transports monocarboxylates from extracellular region to cytosol

Stable Identifier
R-HSA-429749
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Na+-dependent monocarboxylate transport by SMCT
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The human tumour suppressor gene SLC5A8 encodes sodium-coupled monocarboxylate transporter 1, SMCT1 (also called AIT) and is abundantly expressed in the colon (Coady et al. 2004, Myauchi et al. 2004). When the human protein is expressed in Xenopus oocytes, it was found to transport small monocarboxylates and carboxylate drugs, co-transporting Na+ ions electrogenically (3 Na+ ions co-transported with 1 carboxylate).

Literature References
PubMed ID Title Journal Year
15090606 The human tumour suppressor gene SLC5A8 expresses a Na+-monocarboxylate cotransporter

Coady, MJ, Chang, MH, Charron, FM, Plata, C, Wallendorff, B, Sah, JF, Markowitz, SD, Romero, MF, Lapointe, JY

J Physiol 2004
14966140 Functional identification of SLC5A8, a tumor suppressor down-regulated in colon cancer, as a Na(+)-coupled transporter for short-chain fatty acids

Miyauchi, S, Gopal, E, Fei, YJ, Ganapathy, V

J Biol Chem 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
monocarboxylic acid transmembrane transporter activity of SLC5A8 [plasma membrane]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created