Reactome | SLC5A8 transports monocarboxylates from extracellular region to cytosol

SLC5A8 transports monocarboxylates from extracellular region to cytosol

Stable Identifier

R-HSA-429749

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

Synonyms

Na+-dependent monocarboxylate transport by SMCT

ReviewStatus

5/5

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SLC5A8 transports monocarboxylates from extracellular region to cytosol

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The human tumour suppressor gene SLC5A8 encodes sodium-coupled monocarboxylate transporter 1, SMCT1 (also called AIT) and is abundantly expressed in the colon (Coady et al. 2004, Myauchi et al. 2004). When the human protein is expressed in Xenopus oocytes, it was found to transport small monocarboxylates and carboxylate drugs, co-transporting Na+ ions electrogenically (3 Na+ ions co-transported with 1 carboxylate).

Literature References

PubMed ID	Title	Journal	Year
14966140	Functional identification of SLC5A8, a tumor suppressor down-regulated in colon cancer, as a Na(+)-coupled transporter for short-chain fatty acids Ganapathy, V, Gopal, E, Miyauchi, S, Fei, YJ	J Biol Chem	2004
15090606	The human tumour suppressor gene SLC5A8 expresses a Na+-monocarboxylate cotransporter Markowitz, SD, Charron, FM, Coady, MJ, Romero, MF, Sah, JF, Wallendorff, B, Lapointe, JY, Chang, MH, Plata, C	J Physiol	2004