SLC5A8 transports monocarboxylates from extracellular region to cytosol

Stable Identifier
R-HSA-429749
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Na+-dependent monocarboxylate transport by SMCT
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The human tumour suppressor gene SLC5A8 encodes sodium-coupled monocarboxylate transporter 1, SMCT1 (also called AIT) and is abundantly expressed in the colon (Coady et al. 2004, Myauchi et al. 2004). When the human protein is expressed in Xenopus oocytes, it was found to transport small monocarboxylates and carboxylate drugs, co-transporting Na+ ions electrogenically (3 Na+ ions co-transported with 1 carboxylate).

Literature References
PubMed ID Title Journal Year
14966140 Functional identification of SLC5A8, a tumor suppressor down-regulated in colon cancer, as a Na(+)-coupled transporter for short-chain fatty acids

Ganapathy, V, Gopal, E, Miyauchi, S, Fei, YJ

J Biol Chem 2004
15090606 The human tumour suppressor gene SLC5A8 expresses a Na+-monocarboxylate cotransporter

Markowitz, SD, Charron, FM, Coady, MJ, Romero, MF, Sah, JF, Wallendorff, B, Lapointe, JY, Chang, MH, Plata, C

J Physiol 2004
Participants
Participates
Catalyst Activity

monocarboxylic acid transmembrane transporter activity of SLC5A8 [plasma membrane]

Orthologous Events
Cross References
Rhea
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Created
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