PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation)

Stable Identifier
R-HSA-8938073
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation)
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Poly (ADP-ribose) polymerases (PARPs) catalyse the poly(ADP-ribosyl)ation posttranslational modification of proteins. At least 18 human members share homology with the catalytic domain of the founding member, PARP1. PARPs cleave the glycosidic bond of NAD+ between nicotinamide (NAM) and ribose followed by the covalent modification of mainly glutamate residues on acceptor proteins with an ADP-ribosyl unit, with subsequent ADP-ribosyl unit additions linked by glycosidic ribose-ribose bonds. NAM can be utilised in the NAD+ regeneration process. Poly(ADP-ribosyl)ation is important in many biological processess including DNA repair, regulation of chromosome structure, transcriptional regulation, mitosis and apoptosis. PARPs can localise to either the cytosol or the nucleus. The cytosolic PARPs described here are PARP9, PARP10 and PARP16 (Yan et al. 2013, Yu et al. 2005, Di Paolo et al. 2012). PARP4, PARP6, PARP8 and PARP14 may also be located in the cytosol with the same functionality.

Literature References
PubMed ID Title Journal Year
22701565 PARP16/ARTD15 is a novel endoplasmic-reticulum-associated mono-ADP-ribosyltransferase that interacts with, and modifies karyopherin-ß1

Di Paola, S, Micaroni, M, Di Tullio, G, Buccione, R, Di Girolamo, M

PLoS ONE 2012
15674325 PARP-10, a novel Myc-interacting protein with poly(ADP-ribose) polymerase activity, inhibits transformation

Yu, M, Schreek, S, Cerni, C, Schamberger, C, Lesniewicz, K, Poreba, E, Vervoorts, J, Walsemann, G, Grötzinger, J, Kremmer, E, Mehraein, Y, Mertsching, J, Kraft, R, Austen, M, Lüscher-Firzlaff, J, Lüscher, B

Oncogene 2005
23230272 BAL1 and its partner E3 ligase, BBAP, link Poly(ADP-ribose) activation, ubiquitylation, and double-strand DNA repair independent of ATM, MDC1, and RNF8

Yan, Q, Xu, R, Zhu, L, Cheng, X, Wang, Z, Manis, J, Shipp, MA

Mol. Cell. Biol. 2013
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
NAD+ ADP-ribosyltransferase activity of PARPs [cytosol]
Physical Entity
PARPs [cytosol]
Activity
NAD+ ADP-ribosyltransferase activity (0003950)
Orthologous Events
PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Bos taurus)
PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Canis familiaris)
PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Danio rerio)
PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Dictyostelium discoideum)
PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Drosophila melanogaster)
PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Gallus gallus)
PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Mus musculus)
PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Rattus norvegicus)
PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Sus scrofa)
PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Xenopus tropicalis)
Authored
Jassal, B  (2016-09-08)
Reviewed
D'Eustachio, P  (2016-10-11)
Created
Jassal, B  (2016-09-08)