NMNAT1 catalyzes the reaction of nicotinate D-ribonucleotide and ATP to form deamino-NAD+ (nicotinate adenine dinucleotide) and pyrophosphate (Schweiger et al. 2001). The active form of the enzyme in vitro is a hexamer (Zhou et al. 2002), and its activity is substantially greater in the presence of Zn++ than of Mg++ (Sorci et al. 2007). The predicted amino acid sequence of the enzyme contains a nuclear localization domain and the protein is observed to localize to the nucleus (Schweiger et al. 2001; Berger et al. 2005).
Zhou, T, Kurnasov, OV, Tomchick, DR, Binns, DD, Grishin, NV, Marquez, VE, Osterman, AL, Zhang, H
Sorci, L, Cimadamore, F, Scotti, S, Petrelli, R, Cappellacci, L, Franchetti, P, Orsomando, G, Magni, G
Schweiger, M, Hennig, K, Lerner, F, Niere, M, Hirsch-Kauffmann, M, Specht, T, Weise, C, Oei, SL, Ziegler, M
Berger, F, Lau, C, Dahlmann, M, Ziegler, M
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