NMNAT1 catalyzes the reaction of nicotinate D-ribonucleotide and ATP to form deamino-NAD+ (nicotinate adenine dinucleotide) and pyrophosphate (Schweiger et al. 2001). The active form of the enzyme in vitro is a hexamer (Zhou et al. 2002), and its activity is substantially greater in the presence of Zn++ than of Mg++ (Sorci et al. 2007). The predicted amino acid sequence of the enzyme contains a nuclear localization domain and the protein is observed to localize to the nucleus (Schweiger et al. 2001; Berger et al. 2005).
Magni, G, Petrelli, R, Scotti, S, Orsomando, G, Cimadamore, F, Franchetti, P, Sorci, L, Cappellacci, L
Kurnasov, OV, Marquez, VE, Binns, DD, Osterman, AL, Tomchick, DR, Zhang, H, Zhou, T, Grishin, NV
Oei, SL, Hirsch-Kauffmann, M, Hennig, K, Ziegler, M, Lerner, F, Schweiger, M, Weise, C, Specht, T, Niere, M
Ziegler, M, Berger, F, Dahlmann, M, Lau, C
nicotinate-nucleotide adenylyltransferase activity of 6xNMNAT1:6xZn2+ [nucleoplasm]
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