NMRK2 (nicotinamide riboside kinase 2) catalyzes the reaction of NR (N-ribosylnicotinamide) and ATP to yield NMN (beta-nicotinamide D-ribonucleotide), ADP, and H+ (Bieganowsky & Brenner 2004; Tempel et al. 2007). The reaction is annotated with ATP(4-), the major ionized form of ATP at pH 7.2 (Stockbridge & Wolfenden 2009), as the phosphate donor. NMRK2 is a cytosolic enzyme (Nikiforov et al. 2011), localized predominantly in myocytes (Li et al. 1999).
Nikiforov, A, Dölle, C, Niere, M, Ziegler, M
Bieganowski, P, Brenner, C
Tempel, W, Rabeh, WM, Bogan, KL, Belenky, P, Wojcik, M, Seidle, HF, Nedyalkova, L, Yang, T, Sauve, AA, Park, HW, Brenner, C
Li, J, Mayne, R, Wu, C
Stockbridge, RB, Wolfenden, R
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