NMRK2 phosphorylates NR to yield NMN

Stable Identifier
R-HSA-8869627
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
NR + ATP(4-) => NMN + ADP(3-) + H+
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NMRK2 (nicotinamide riboside kinase 2) catalyzes the reaction of NR (N-ribosylnicotinamide) and ATP to yield NMN (beta-nicotinamide D-ribonucleotide), ADP, and H+ (Bieganowsky & Brenner 2004; Tempel et al. 2007). The reaction is annotated with ATP(4-), the major ionized form of ATP at pH 7.2 (Stockbridge & Wolfenden 2009), as the phosphate donor. NMRK2 is a cytosolic enzyme (Nikiforov et al. 2011), localized predominantly in myocytes (Li et al. 1999).

Literature References
Participants
Participates
Catalyst Activity

ribosylnicotinamide kinase activity of NMRK2 [cytosol]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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