NMRK2 (nicotinamide riboside kinase 2) catalyzes the reaction of NR (N-ribosylnicotinamide) and ATP to yield NMN (beta-nicotinamide D-ribonucleotide), ADP, and H+ (Bieganowsky & Brenner 2004; Tempel et al. 2007). The reaction is annotated with ATP(4-), the major ionized form of ATP at pH 7.2 (Stockbridge & Wolfenden 2009), as the phosphate donor. NMRK2 is a cytosolic enzyme (Nikiforov et al. 2011), localized predominantly in myocytes (Li et al. 1999).
Bieganowski, P, Brenner, C
Ziegler, M, Nikiforov, A, Dölle, C, Niere, M
Sauve, AA, Park, HW, Yang, T, Belenky, P, Seidle, HF, Tempel, W, Nedyalkova, L, Wojcik, M, Rabeh, WM, Bogan, KL, Brenner, C
Mayne, R, Wu, C, Li, J
Wolfenden, R, Stockbridge, RB
ribosylnicotinamide kinase activity of NMRK2 [cytosol]
© 2022 Reactome
