Reactome | NMRK2 phosphorylates NR to yield NMN

NMRK2 phosphorylates NR to yield NMN

Stable Identifier

R-HSA-8869627

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

beta-nicotinamide D-riboside + ATP => beta-nicotinamide D-ribonucleotide + ADP + H(+), NR + ATP(4-) => NMN + ADP(3-) + H+

ReviewStatus

5/5

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Cytosolic NMRK2 (nicotinamide riboside kinase 2), localized predominantly in myocytes (Li et al. 1999), catalyzes the reaction of NR (N-ribosylnicotinamide) and ATP to yield NMN (beta-nicotinamide D-ribonucleotide), ADP, and H+ (Bieganowsky & Brenner 2004; Tempel et al. 2007). Covarrubias et al. (2021) suggest that extracellular NR is taken up via a specific transporter in the plasma membrane, but while proteins with this activity have been identified in prokaryotes and fungi, no homolog has been identified in mammals.

Literature References

PubMed ID	Title	Journal	Year
15137942	Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans Bieganowski, P, Brenner, C	Cell	2004
33353981	NAD⁺ metabolism and its roles in cellular processes during ageing Verdin, E, Grozio, A, Covarrubias, AJ, Perrone, R	Nat Rev Mol Cell Biol	2021
21504897	Pathways and subcellular compartmentation of NAD biosynthesis in human cells: from entry of extracellular precursors to mitochondrial NAD generation Ziegler, M, Nikiforov, A, Dölle, C, Niere, M	J. Biol. Chem.	2011
17914902	Nicotinamide riboside kinase structures reveal new pathways to NAD+ Sauve, AA, Park, HW, Yang, T, Belenky, P, Seidle, HF, Tempel, W, Nedyalkova, L, Wojcik, M, Rabeh, WM, Bogan, KL, Brenner, C	PLoS Biol.	2007
10613898	A novel muscle-specific beta 1 integrin binding protein (MIBP) that modulates myogenic differentiation Mayne, R, Wu, C, Li, J	J. Cell Biol.	1999
19531469	The intrinsic reactivity of ATP and the catalytic proficiencies of kinases acting on glucose, N-acetylgalactosamine, and homoserine: a thermodynamic analysis Wolfenden, R, Stockbridge, RB	J. Biol. Chem.	2009