NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD

Stable Identifier
R-HSA-200474
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT3]
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NMNAT3 catalyzes the reaction of nicotinate D-ribonucleotide and ATP to form deamino-NAD+ (nicotinate adenine dinucleotide) and pyrophosphate (Sorci et al. 2007). The active form of the enzyme is a tetramer in vitro (Zhang et al. 2003). Recombinant FLAG-tagged protein expressed in HeLa cells localizes both to the cytosol and to mitochondria (Berger et al. 2005). The cytosolic protein is annotated here.

Literature References
PubMed ID Title Journal Year
12574164 Structural characterization of a human cytosolic NMN/NaMN adenylyltransferase and implication in human NAD biosynthesis

Zhang, X, Kurnasov, OV, Osterman, AL, Karthikeyan, S, Zhang, H, Grishin, NV

J Biol Chem 2003
17402747 Initial-rate kinetics of human NMN-adenylyltransferases: substrate and metal ion specificity, inhibition by products and multisubstrate analogues, and isozyme contributions to NAD+ biosynthesis

Magni, G, Petrelli, R, Scotti, S, Orsomando, G, Cimadamore, F, Franchetti, P, Sorci, L, Cappellacci, L

Biochemistry 2007
16118205 Subcellular compartmentation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoforms

Ziegler, M, Berger, F, Dahlmann, M, Lau, C

J Biol Chem 2005
Participants
Participates
Catalyst Activity

nicotinate-nucleotide adenylyltransferase activity of 4xNMNAT3:4xMg2+ [mitochondrial matrix]

Orthologous Events
Cross References
Rhea
Authored
Created
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