Reactome | NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD

NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD

Stable Identifier

R-HSA-200474

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT3]

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

NMNAT3 catalyzes the reaction of nicotinate D-ribonucleotide and ATP to form deamino-NAD+ (nicotinate adenine dinucleotide) and pyrophosphate (Sorci et al. 2007). The active form of the enzyme is a tetramer in vitro (Zhang et al. 2003). Recombinant FLAG-tagged protein expressed in HeLa cells localizes both to the cytosol and to mitochondria (Berger et al. 2005). The cytosolic protein is annotated here.

Literature References

PubMed ID	Title	Journal	Year
17402747	Initial-rate kinetics of human NMN-adenylyltransferases: substrate and metal ion specificity, inhibition by products and multisubstrate analogues, and isozyme contributions to NAD+ biosynthesis Sorci, L, Cimadamore, F, Scotti, S, Petrelli, R, Cappellacci, L, Franchetti, P, Orsomando, G, Magni, G	Biochemistry	2007
12574164	Structural characterization of a human cytosolic NMN/NaMN adenylyltransferase and implication in human NAD biosynthesis Zhang, X, Kurnasov, OV, Karthikeyan, S, Grishin, NV, Osterman, AL, Zhang, H	J Biol Chem	2003
16118205	Subcellular compartmentation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoforms Berger, F, Lau, C, Dahlmann, M, Ziegler, M	J Biol Chem	2005