NMRK1 (nicotinamide riboside kinase 1) catalyzes the reaction of NAR (N-ribosylnicotinate) and ATP to yield NAMN (beta-nicotinate D-ribonucleotide), ADP, and H+ (Tempel et al. 2007). The reaction is annotated with ATP(4-), the major ionized form of ATP at pH 7.2 (Stockbridge & Wolfenden 2009), as the phosphate donor. NMRK1 is a cytosolic enzyme (Nikiforov et al. 2011).
Ziegler, M, Nikiforov, A, Dölle, C, Niere, M
Sauve, AA, Park, HW, Yang, T, Belenky, P, Seidle, HF, Tempel, W, Nedyalkova, L, Wojcik, M, Rabeh, WM, Bogan, KL, Brenner, C
Wolfenden, R, Stockbridge, RB
ribosylnicotinate kinase activity of NMRK1 [cytosol]
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