Reactome | NMRK1 phosphorylates NR to yield NMN

NMRK1 phosphorylates NR to yield NMN

Stable Identifier

R-HSA-8869633

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

beta-nicotinamide D-riboside + ATP => beta-nicotinamide D-ribonucleotide + ADP + H(+), NR + ATP(4-) => NMN + ADP(3-) + H+

ReviewStatus

5/5

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Cytosolic NMRK1 (nicotinamide riboside kinase 1) (Nikiforov et al. 2011) catalyzes the reaction of NR (N-ribosylnicotinamide) and ATP to yield NMN (beta-nicotinamide D-ribonucleotide), ADP, and H+. The enzyme is also active with GTP as a phosphate donor (not annotated here) (Bieganowsky & Brenner 2004; Sasiak & Saunders 1996; Tempel et al. 2007). Covarrubias et al. (2021) suggest that extracellular NR is taken up via a specific transporter in the plasma membrane, but while proteins with this activity have been identified in prokaryotes and fungi, no homolog has been identified in mammals.

Literature References

PubMed ID	Title	Journal	Year
15137942	Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans Bieganowski, P, Brenner, C	Cell	2004
8809081	Purification and properties of a human nicotinamide ribonucleoside kinase Sasiak, K, Saunders, PP	Arch. Biochem. Biophys.	1996
33353981	NAD⁺ metabolism and its roles in cellular processes during ageing Covarrubias, AJ, Perrone, R, Grozio, A, Verdin, E	Nat Rev Mol Cell Biol	2021
21504897	Pathways and subcellular compartmentation of NAD biosynthesis in human cells: from entry of extracellular precursors to mitochondrial NAD generation Nikiforov, A, Dölle, C, Niere, M, Ziegler, M	J. Biol. Chem.	2011
17914902	Nicotinamide riboside kinase structures reveal new pathways to NAD+ Tempel, W, Rabeh, WM, Bogan, KL, Belenky, P, Wojcik, M, Seidle, HF, Nedyalkova, L, Yang, T, Sauve, AA, Park, HW, Brenner, C	PLoS Biol.	2007
19531469	The intrinsic reactivity of ATP and the catalytic proficiencies of kinases acting on glucose, N-acetylgalactosamine, and homoserine: a thermodynamic analysis Stockbridge, RB, Wolfenden, R	J. Biol. Chem.	2009