NAD kinase is the sole NADP(+) biosynthetic enzyme. A cytosolic form of NAD kinase is already characterised but recently, a mitochondrial form has been found to exist. Mitochondrial NAD kinase 2 (NADK2 aka C5orf33, MNADK, NADKD1) uses ATP to phosphorylate NAD+ to NADP+ (Ohashi et al. 2012). NADK2 is ubiquitously expressed and is more abundant than its cytosolic counterpart. Defects in NADK2 can cause 2,4-dienoyl-CoA reductase deficiency (DECRD), a rare, autosomal recessive, inborn error of polyunsaturated fatty acids and lysine metabolism, resulting in mitochondrial dysfunction (Houten et al. 2014).
Ohashi, K, Kawai, S, Murata, K
Houten, SM, Denis, S, Te Brinke, H, Jongejan, A, van Kampen, AH, Bradley, EJ, Baas, F, Hennekam, RC, Millington, DS, Young, SP, Frazier, DM, Gucsavas-Calikoglu, M, Wanders, RJ
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