CARKD dehydrates S-NAD(P)HX to NADPH

Stable Identifier
R-HSA-6806967
Type
Reaction
Species
Homo sapiens
Compartment
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Human ATP-dependent (S)-NAD(P)H-hydrate dehydratase (CARKD) is thought to catalyze the dehydration, and thus repair, of the S-form of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. The human event is deduced on the basis of evidence from mouse experiments (Marbaix et al. 2011).

Literature References
PubMed ID Title Journal Year
21994945 Extremely conserved ATP- or ADP-dependent enzymatic system for nicotinamide nucleotide repair

Linster, CL, Vertommen, D, Noel, G, Detroux, AM, Van Schaftingen, E, Marbaix, AY

J. Biol. Chem. 2011
Participants
Participates
Catalyst Activity

ATP-dependent NAD(P)H-hydrate dehydratase activity of CARKD [mitochondrial matrix]

Orthologous Events
Cross References
Rhea
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Reviewed
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