Reactome | CARKD dehydrates S-NAD(P)HX to NADPH

CARKD dehydrates S-NAD(P)HX to NADPH

Stable Identifier

R-HSA-6806967

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

(6S)-NADPHX + ATP => ADP + phosphate + NADPH + H(+)

ReviewStatus

5/5

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Human ATP-dependent (S)-NAD(P)H-hydrate dehydratase (CARKD) is thought to catalyze the dehydration, and thus repair, of the S-form of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. The human event is deduced on the basis of evidence from mouse experiments (Marbaix et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
21994945	Extremely conserved ATP- or ADP-dependent enzymatic system for nicotinamide nucleotide repair Marbaix, AY, Noel, G, Detroux, AM, Vertommen, D, Van Schaftingen, E, Linster, CL	J. Biol. Chem.	2011