CARKD dehydrates S-NAD(P)HX to NADPH

Stable Identifier
R-HSA-6806967
Type
Reaction
Species
Homo sapiens
Compartment
mitochondrial matrix
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CARKD dehydrates S-NAD(P)HX to NADPH
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Human ATP-dependent (S)-NAD(P)H-hydrate dehydratase (CARKD) is thought to catalyze the dehydration, and thus repair, of the S-form of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. The human event is deduced on the basis of evidence from mouse experiments (Marbaix et al. 2011).

Literature References
PubMed ID Title Journal Year
21994945 Extremely conserved ATP- or ADP-dependent enzymatic system for nicotinamide nucleotide repair

Linster, CL, Vertommen, D, Noel, G, Detroux, AM, Van Schaftingen, E, Marbaix, AY

J. Biol. Chem. 2011
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Catalyst Activity

ATP-dependent NAD(P)H-hydrate dehydratase activity of CARKD [mitochondrial matrix]

Physical Entity
CARKD [mitochondrial matrix] (Homo sapiens)
Activity
ATP-dependent NAD(P)H-hydrate dehydratase activity (GO:0047453)
Orthologous Events
CARKD dehydrates S-NAD(P)HX to NADPH (Bos taurus)
CARKD dehydrates S-NAD(P)HX to NADPH (Caenorhabditis elegans)
CARKD dehydrates S-NAD(P)HX to NADPH (Canis familiaris)
CARKD dehydrates S-NAD(P)HX to NADPH (Danio rerio)
CARKD dehydrates S-NAD(P)HX to NADPH (Dictyostelium discoideum)
CARKD dehydrates S-NAD(P)HX to NADPH (Drosophila melanogaster)
CARKD dehydrates S-NAD(P)HX to NADPH (Gallus gallus)
CARKD dehydrates S-NAD(P)HX to NADPH (Mus musculus)
CARKD dehydrates S-NAD(P)HX to NADPH (Plasmodium falciparum)
CARKD dehydrates S-NAD(P)HX to NADPH (Rattus norvegicus)
CARKD dehydrates S-NAD(P)HX to NADPH (Saccharomyces cerevisiae)
CARKD dehydrates S-NAD(P)HX to NADPH (Schizosaccharomyces pombe)
CARKD dehydrates S-NAD(P)HX to NADPH (Sus scrofa)
CARKD dehydrates S-NAD(P)HX to NADPH (Xenopus tropicalis)
Cross References
Rhea
Authored
Jassal, B  (2015-10-28)
Reviewed
D'Eustachio, P  (2016-01-11)
Created
Jassal, B  (2015-10-28)
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