RNLS:FAD oxidises dh-beta-NAD to NAD+

Stable Identifier
R-HSA-8956458
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Renalase (RNLS) is a flavoprotein that is secreted by the kidney and circulates in blood from where it can regulate blood pressure, regulate sodium and phosphate excretion and display cardioprotectivity through a mechanism which is not understood to date. RNLS, using FAD as cofactor, can oxidise isomeric forms of beta-NAD(P)H that can arise either by nonspecific reduction of beta-NAD(P)+ or by tautomerisation of beta-NAD(P)H (Milani et al. 2011, Beaupre et al. 2015). These forms are 1,2- and 1,6-dihydroNAD(P) (dh-beta-NAD(P)) and are potent inhibitors of primary metabolism dehydrogenases. RNLS may thus play a role in eliminating these isomeric forms which threaten normal respiratory activity.

Literature References
PubMed ID Title Journal Year
21699903 FAD-binding site and NADP reactivity in human renalase: a new enzyme involved in blood pressure regulation

Milani, M, Ciriello, F, Baroni, S, Pandini, V, Canevari, G, Bolognesi, M, Aliverti, A

J. Mol. Biol. 2011
25531177 Metabolic function for human renalase: oxidation of isomeric forms of ╬▓-NAD(P)H that are inhibitory to primary metabolism

Beaupre, BA, Hoag, MR, Roman, J, F├Ârsterling, FH, Moran, GR

Biochemistry 2015
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Catalyst Activity
Title
oxidoreductase activity, acting on NAD(P)H of RNLS:FAD [extracellular region]
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Orthologous Events
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