Renalase (RNLS) is a flavoprotein that is secreted by the kidney and circulates in blood from where it can regulate blood pressure, regulate sodium and phosphate excretion and display cardioprotectivity through a mechanism which is not understood to date. RNLS, using FAD as cofactor, can oxidise isomeric forms of beta-NAD(P)H that can arise either by nonspecific reduction of beta-NAD(P)+ or by tautomerisation of beta-NAD(P)H (Milani et al. 2011, Beaupre et al. 2015). These forms are 1,2- and 1,6-dihydroNAD(P) (dh-beta-NAD(P)) and are potent inhibitors of primary metabolism dehydrogenases. RNLS may thus play a role in eliminating these isomeric forms which threaten normal respiratory activity.
Moran, GR, Roman, J, Försterling, FH, Hoag, MR, Beaupre, BA
Aliverti, A, Bolognesi, M, Baroni, S, Canevari, G, Ciriello, F, Milani, M, Pandini, V
oxidoreductase activity, acting on NAD(P)H of RNLS:FAD [extracellular region]
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