5'-nucleotidase (NT5E, CD73) is able to hydrolyse extracellular nucleotides into membrane permeable nucleosides. It displays a broad specificity, acting on mono- or di-nucleotide nicotinamides and different adenosine phosphates, with maximal activity on 5'-adenosine monophosphate. Human NT5E can hydrolyse both NAD+ and NMN, suggesting a role in NAD metabolism (Garavaglia et al. 2012). NT5E is a glycolipid-anchored plasma membrane enzyme (Misumi et al. 1990) that is active in dimeric form and requires one zinc ion per subunit (Zimmermann 1992).
Zimmermann, H
Ogata, S, Ikehara, Y, Misumi, Y, Hirose, S, Ohkubo, K
Sturla, L, Canella, L, Garavaglia, S, Mannino, E, Rizzi, M, Allegrone, G, Millo, E, Bruzzone, S, De Flora, A, Cassani, C
5'-nucleotidase activity of NT5E:Zn2+ dimer [plasma membrane]
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