Reactome | HIST1H2BO [extracellular region]

HIST1H2BO [extracellular region]

Stable Identifier

R-HSA-977557

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Histone H2B.n

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Amyloid fiber formation (Homo sapiens)
  - Serum amyloid P binds DNA and chromatin (Homo sapiens)
    - Double-stranded DNA and chromatin [extracellular region] (Homo sapiens)
      - Chromatin [extracellular region] (Homo sapiens)
        
        Nucleosome (Deacetylated) [extracellular region] (Homo sapiens)
        
        Histone H2B [extracellular region] (Homo sapiens)
        
        HIST1H2BO [extracellular region] (Homo sapiens)
    - Serum amyloid P-component pentamer:Double-stranded DNA [extracellular region] (Homo sapiens)
      - Double-stranded DNA and chromatin [extracellular region] (Homo sapiens)
        
        Chromatin [extracellular region] (Homo sapiens)
        
        Nucleosome (Deacetylated) [extracellular region] (Homo sapiens)
        
        Histone H2B [extracellular region] (Homo sapiens)
        
        HIST1H2BO [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P23527 H2BC17

Gene Names

H2BC17, H2BFH, H2BFN, HIST1H2BO

Chain

initiator methionine:, chain:2-126

Reference Genes

BioGPS Gene:8348 H2BC17

COSMIC (genes):HIST1H2BO H2BC17

CTD Gene:8348 H2BC17

dbSNP Gene:8348 H2BC17

ENSEMBL:ENSG00000274641 HIST1H2BO

HGNC:4758 H2BC17

KEGG:hsa:8348 H2BC17

Monarch:8348 H2BC17

NCBI Gene:8348 H2BC17

OMIM:602808 H2BC17

UCSC:P23527 H2BC17

Reference Transcript

RefSeq:NM_003527.4 H2BC17

Other Identifiers

11742176_s_at

17005880

214540_PM_at

214540_at

2900118

2900119

2900120

8117614

8348

ADDON002745.hg

A_23_P59069

GO:0000786

GO:0003677

GO:0005198

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005829

GO:0006325

GO:0006334

GO:0030527

GO:0043226

GO:0043229

GO:0046982

GO:0065003

HMNXSV003007889

Hs.151506.0.S1_3p_at

Hs.151506.0.S1_3p_x_at

ILMN_1739076

PH_hs_0036083

TC06000270.hg

Participates

as a candidate of

Histone H2B [extracellular region] (Homo sapiens)

Other forms of this molecule

Ub-HIST1H2BO [nucleoplasm]

AcK-HIST1H2BO [nucleoplasm]

AcK13-HIST1H2BO [nucleoplasm]

AcK21-HIST1H2BO [nucleoplasm]

AcK16-HIST1H2BO [nucleoplasm]

AcK6-HIST1H2BO [nucleoplasm]

Ub-121-HIST1H2BO [nucleoplasm]

HIST1H2BO [nucleoplasm]

Cross References

RefSeq

NP_003518.2

ENSEMBL

ENST00000616182, ENSP00000477527

OpenTargets

ENSG00000274641

HPA

ENSG00000274641-H2BC17

PRO

P23527

Pharos - Targets

P23527

GlyGen

P23527

PDB

7WLP

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q01831 XPC	5	monoSUMO1-K655-XPC [nucleoplasm] (R-HSA-4570458) Ub,SUMO,K63polyUb-XPC [nucleoplasm] (R-HSA-6790522) Ub,SUMO-XPC [nucleoplasm] (R-HSA-6790460) Ub-XPC [nucleoplasm] (R-HSA-6782944) XPC [nucleoplasm] (R-HSA-67441)	0.527	3
UniProt:P16104 H2AFX	7	H2AFX [nucleoplasm] (R-HSA-56151) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-S140-H2AFX [nucleoplasm] (R-HSA-75170) K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) H2AFX [extracellular region] (R-HSA-977583) Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317)	0.527	3
UniProt:Q8NAV1 PRPF38A	1	PRPF38A [nucleoplasm] (R-HSA-8867897)	0.508	2