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Ub-HIST1H2BA [nucleoplasm]
Stable Identifier
R-HSA-6782561
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
HIST1H2BA, Histone H2B, testis
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
Ub-specific processing proteases (Homo sapiens)
USP3,SAGA deubiquitinate Histone H2A,H2B (Homo sapiens)
USP3,SAGA:Ub-histone H2A, Ub-histone H2B [nucleoplasm] (Homo sapiens)
Ub-histone H2A, Ub-histone H2B [nucleoplasm] (Homo sapiens)
Ub-histone H2B [nucleoplasm] (Homo sapiens)
Ub-histone HIST1H2B [nucleoplasm] (Homo sapiens)
Ub-HIST1H2BA [nucleoplasm] (Homo sapiens)
USP49 deubiquitinates H2B (Homo sapiens)
USP49:Ub-histone H2B [nucleoplasm] (Homo sapiens)
Ub-histone H2B [nucleoplasm] (Homo sapiens)
Ub-histone HIST1H2B [nucleoplasm] (Homo sapiens)
Ub-HIST1H2BA [nucleoplasm] (Homo sapiens)
Protein ubiquitination (Homo sapiens)
E3 ubiquitin ligases ubiquitinate target proteins (Homo sapiens)
RNF20:RNF40 monoubiquitinates Histone H2B (Homo sapiens)
Ub-histone HIST1H2B [nucleoplasm] (Homo sapiens)
Ub-HIST1H2BA [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96A08 H2BC1
Gene Names
H2BC1, HIST1H2BA, TSH2B
Chain
initiator methionine:, chain:2-127
Reference Genes
BioGPS Gene:255626 H2BC1
COSMIC (genes):HIST1H2BA H2BC1
CTD Gene:255626 H2BC1
dbSNP Gene:255626 H2BC1
ENSEMBL:ENSG00000146047 HIST1H2BA
HGNC:18730 H2BC1
KEGG:hsa:255626 H2BC1
Monarch:255626 H2BC1
NCBI Gene:255626 H2BC1
OMIM:609904 H2BC1
UCSC:Q96A08 H2BC1
Reference Transcript
RefSeq:NM_170610.2 H2BC1
Other Identifiers
11732488_at
17005488
241519_PM_at
241519_at
255626
2898973
2898974
2898975
61091_at
8117301
A_23_P323823
GO:0000781
GO:0000786
GO:0001674
GO:0002376
GO:0003674
GO:0003677
GO:0005198
GO:0005634
GO:0005654
GO:0005694
GO:0006325
GO:0006334
GO:0006337
GO:0006954
GO:0009986
GO:0030527
GO:0031639
GO:0035092
GO:0042393
GO:0043226
GO:0043229
GO:0046982
GO:0048870
GO:0051276
GO:0051604
GO:0065003
GO:0071674
HMNXSV003021484
Hs.188762.0.A1_3p_at
ILMN_2108779
TC06000158.hg
Participates
as a member of
Ub-histone HIST1H2B [nucleoplasm] (Homo sapiens)
Other forms of this molecule
HIST1H2BA [nucleoplasm]
Ub-122-HIST1H2BA [nucleoplasm]
AcK22-HIST1H2BA [nucleoplasm]
AcK17-HIST1H2BA [nucleoplasm]
AcK14-HIST1H2BA [nucleoplasm]
AcK7-HIST1H2BA [nucleoplasm]
HIST1H2BA [extracellular region]
AcK-HIST1H2BA [nucleoplasm]
Inferred To
H2Bv1 [nucleoplasm]
(Dictyostelium discoideum)
His2B [nucleoplasm]
(Drosophila melanogaster)
H2Bv3 [nucleoplasm]
(Dictyostelium discoideum)
H2Bv2 [nucleoplasm]
(Dictyostelium discoideum)
htb1 [nucleoplasm]
(Schizosaccharomyces pombe)
H2bc1 [nucleoplasm]
(Mus musculus)
H2bc1 [nucleoplasm]
(Rattus norvegicus)
Homologues of Ub-HIST1H2BA [nucleoplasm]
(Canis familiaris)
Homologues of Ub-HIST1H2BA [nucleoplasm]
(Dictyostelium discoideum)
Homologues of Ub-HIST1H2BA [nucleoplasm]
(Saccharomyces cerevisiae)
Ub-HIST1H2BA [nucleoplasm]
(Sus scrofa)
H2BC2 [nucleoplasm]
(Canis familiaris)
HTB1 [nucleoplasm]
(Saccharomyces cerevisiae)
LOC426037 [nucleoplasm]
(Gallus gallus)
HTB2 [nucleoplasm]
(Saccharomyces cerevisiae)
Modified Residues
Name
ubiquitinylated lysine (monoUb [nucleoplasm]) at 120
Coordinate
120
Modification
monoUb [nucleoplasm]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
NP_733759.1
OpenTargets
ENSG00000146047
ENSEMBL
ENST00000274764
,
ENSP00000274764
HPA
ENSG00000146047-H2BC1
PRO
Q96A08
Pharos - Targets
Q96A08
GlyGen
Q96A08
PDB
3WKJ
,
5GSU
,
5GT3
,
6BIY
Interactors (14)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P41208 CETN2
3
CETN2 [cytosol]
(R-HSA-380298)
CETN2 [nucleoplasm]
(R-HSA-4570490)
polySUMO2,3-CETN2 [nucleoplasm]
(R-HSA-4570486)
0.527
3
UniProt:Q9Y265 RUVBL1
1
RUVBL1 [nucleoplasm]
(R-HSA-418323)
0.527
4
UniProt:P33993 MCM7
1
MCM7 [nucleoplasm]
(R-HSA-68555)
0.527
4
UniProt:Q96L91 EP400
1
EP400 [nucleoplasm]
(R-HSA-3321987)
0.527
4
UniProt:P49736 MCM2
1
MCM2 [nucleoplasm]
(R-HSA-68557)
0.527
4
UniProt:Q14566 MCM6
1
MCM6 [nucleoplasm]
(R-HSA-68553)
0.527
4
UniProt:P33991 MCM4
1
MCM4 [nucleoplasm]
(R-HSA-68549)
0.527
4
UniProt:Q9Y230 RUVBL2
1
RUVBL2 [nucleoplasm]
(R-HSA-418321)
0.527
3
UniProt:Q9Y5B9 SUPT16H
1
SUPT16H [nucleoplasm]
(R-HSA-112415)
0.527
4
UniProt:Q92769 HDAC2
2
HDAC2 [nucleoplasm]
(R-HSA-205135)
monoSUMO1-K462-HDAC2 [nucleoplasm]
(R-HSA-4615958)
0.527
3
UniProt:Q08945 SSRP1
1
SSRP1 [nucleoplasm]
(R-HSA-65105)
0.527
4
UniProt:Q01831 XPC
5
monoSUMO1-K655-XPC [nucleoplasm]
(R-HSA-4570458)
Ub,SUMO,K63polyUb-XPC [nucleoplasm]
(R-HSA-6790522)
Ub,SUMO-XPC [nucleoplasm]
(R-HSA-6790460)
Ub-XPC [nucleoplasm]
(R-HSA-6782944)
XPC [nucleoplasm]
(R-HSA-67441)
0.527
3
UniProt:Q13547 HDAC1
2
HDAC1 [nucleoplasm]
(R-HSA-205021)
monoSUMO1-K444,K476-HDAC1 [nucleoplasm]
(R-HSA-4616030)
0.527
4
UniProt:O95619 YEATS4
1
YEATS4 [nucleoplasm]
(R-HSA-3322940)
0.527
4
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