Reactome | SUMOylation of XPC with SUMO1

SUMOylation of XPC with SUMO1

Stable Identifier

R-HSA-4570528

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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XPC is SUMOylated at lysine-655 with SUMO1 (Wang et al. 2005, 2007). SUMOylation occurs after UV irradiation and may target XPC for destruction (Wang et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
16030353	DNA repair factor XPC is modified by SUMO-1 and ubiquitin following UV irradiation Wang, QE, Zhu, Q, Wani, G, El-Mahdy, MA, Li, J, Wani, AA	Nucleic Acids Res.	2005
17693435	Ubiquitylation-independent degradation of Xeroderma pigmentosum group C protein is required for efficient nucleotide excision repair Wang, QE, Praetorius-Ibba, M, Zhu, Q, El-Mahdy, MA, Wani, G, Zhao, Q, Qin, S, Patnaik, S, Wani, AA	Nucleic Acids Res.	2007