Reactome | AcK17-HIST1H2BA [nucleoplasm]

AcK17-HIST1H2BA [nucleoplasm]

Stable Identifier

R-HSA-4568631

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

Expand all

Chromatin organization (Homo sapiens)

- Chromatin modifying enzymes (Homo sapiens)
  - HATs acetylate histones (Homo sapiens)
    - EP300 acetylates histone H2A, H2B, H3, H4 (Homo sapiens)
      - AcK-histone H2A, H2B, H3, H4 [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
        
        AcK(7,14,17,22)-HIST1H2BA [nucleoplasm] (Homo sapiens)
        
        AcK17-HIST1H2BA [nucleoplasm] (Homo sapiens)
  - HDACs deacetylate histones (Homo sapiens)
    - HDAC10 deacetylates histone (Homo sapiens)
      - Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
        
        AcK(7,14,17,22)-HIST1H2BA [nucleoplasm] (Homo sapiens)
        
        AcK17-HIST1H2BA [nucleoplasm] (Homo sapiens)
    - HDAC1:2-containing complex deacetylate histones (Homo sapiens)
      - Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
        
        AcK(7,14,17,22)-HIST1H2BA [nucleoplasm] (Homo sapiens)
        
        AcK17-HIST1H2BA [nucleoplasm] (Homo sapiens)
    - HDAC3 containing complexes deacetylate histone (Homo sapiens)
      - Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
        
        AcK(7,14,17,22)-HIST1H2BA [nucleoplasm] (Homo sapiens)
        
        AcK17-HIST1H2BA [nucleoplasm] (Homo sapiens)
    - HDAC8 deacetylates histones (Homo sapiens)
      - Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
        
        AcK(7,14,17,22)-HIST1H2BA [nucleoplasm] (Homo sapiens)
        
        AcK17-HIST1H2BA [nucleoplasm] (Homo sapiens)

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - HCMV Infection (Homo sapiens)
      - HCMV Early Events (Homo sapiens)
        
        Activation of Latent HCMV Genome (Homo sapiens)
        
        Transcriptionally Active HCMV Genome [nucleoplasm] (Homo sapiens)
        
        Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
        
        AcK(7,14,17,22)-HIST1H2BA [nucleoplasm] (Homo sapiens)
        
        AcK17-HIST1H2BA [nucleoplasm] (Homo sapiens)
        
        Delayed Early (DE) Gene Expression (Homo sapiens)
        
        Transcriptionally Active HCMV Genome [nucleoplasm] (Homo sapiens)
        
        Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
        
        AcK(7,14,17,22)-HIST1H2BA [nucleoplasm] (Homo sapiens)
        
        AcK17-HIST1H2BA [nucleoplasm] (Homo sapiens)
        
        Immediate Early (IE) Gene Expression (Homo sapiens)
        
        Transcriptionally Active HCMV Genome [nucleoplasm] (Homo sapiens)
        
        Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
        
        AcK(7,14,17,22)-HIST1H2BA [nucleoplasm] (Homo sapiens)
        
        AcK17-HIST1H2BA [nucleoplasm] (Homo sapiens)
        
        Transcriptional Activation of the HCMV Genome (Homo sapiens)
        
        Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
        
        AcK(7,14,17,22)-HIST1H2BA [nucleoplasm] (Homo sapiens)
        
        AcK17-HIST1H2BA [nucleoplasm] (Homo sapiens)
        
        Transcriptionally Active HCMV Genome [nucleoplasm] (Homo sapiens)
        
        Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
        
        AcK(7,14,17,22)-HIST1H2BA [nucleoplasm] (Homo sapiens)
        
        AcK17-HIST1H2BA [nucleoplasm] (Homo sapiens)
      - HCMV Late Events (Homo sapiens)
        
        Late (L) Gene Expression (Homo sapiens)
        
        Transcriptionally Active HCMV Genome [nucleoplasm] (Homo sapiens)
        
        Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
        
        AcK(7,14,17,22)-HIST1H2BA [nucleoplasm] (Homo sapiens)
        
        AcK17-HIST1H2BA [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96A08 H2BC1

Gene Names

H2BC1, HIST1H2BA, TSH2B

Chain

initiator methionine:, chain:2-127

Reference Genes

BioGPS Gene:255626 H2BC1

COSMIC (genes):HIST1H2BA H2BC1

CTD Gene:255626 H2BC1

dbSNP Gene:255626 H2BC1

ENSEMBL:ENSG00000146047 HIST1H2BA

HGNC:18730 H2BC1

KEGG:hsa:255626 H2BC1

Monarch:255626 H2BC1

NCBI Gene:255626 H2BC1

OMIM:609904 H2BC1

UCSC:Q96A08 H2BC1

Reference Transcript

RefSeq:NM_170610.2 H2BC1

Other Identifiers

11732488_at

17005488

241519_PM_at

241519_at

255626

2898973

2898974

2898975

61091_at

8117301

A_23_P323823

GO:0000781

GO:0000786

GO:0001674

GO:0002376

GO:0003674

GO:0003677

GO:0005198

GO:0005634

GO:0005654

GO:0005694

GO:0006325

GO:0006334

GO:0006337

GO:0006954

GO:0009986

GO:0030527

GO:0031639

GO:0035092

GO:0042393

GO:0043226

GO:0043229

GO:0046982

GO:0048870

GO:0051276

GO:0051604

GO:0065003

GO:0071674

HMNXSV003021484

Hs.188762.0.A1_3p_at

ILMN_2108779

TC06000158.hg

Participates

as a member of

AcK(7,14,17,22)-HIST1H2BA [nucleoplasm] (Homo sapiens)

Other forms of this molecule

HIST1H2BA [nucleoplasm]

Ub-122-HIST1H2BA [nucleoplasm]

AcK22-HIST1H2BA [nucleoplasm]

AcK14-HIST1H2BA [nucleoplasm]

AcK7-HIST1H2BA [nucleoplasm]

HIST1H2BA [extracellular region]

AcK-HIST1H2BA [nucleoplasm]

Ub-HIST1H2BA [nucleoplasm]

Inferred To

H2Bv1 [nucleoplasm] (Dictyostelium discoideum)

His2B [nucleoplasm] (Drosophila melanogaster)

AcK17-HIST1H2BA [nucleoplasm] (Plasmodium falciparum)

AcK17-HIST1H2BA [nucleoplasm] (Sus scrofa)

H2Bv3 [nucleoplasm] (Dictyostelium discoideum)

H2Bv2 [nucleoplasm] (Dictyostelium discoideum)

htb1 [nucleoplasm] (Schizosaccharomyces pombe)

H2bc1 [nucleoplasm] (Mus musculus)

Homologues of AcK17-HIST1H2BA [nucleoplasm] (Canis familiaris)

Homologues of AcK17-HIST1H2BA [nucleoplasm] (Dictyostelium discoideum)

Homologues of AcK17-HIST1H2BA [nucleoplasm] (Plasmodium falciparum)

Homologues of AcK17-HIST1H2BA [nucleoplasm] (Saccharomyces cerevisiae)

H2BC2 [nucleoplasm] (Canis familiaris)

HTB1 [nucleoplasm] (Saccharomyces cerevisiae)

LOC426037 [nucleoplasm] (Gallus gallus)

HTB2 [nucleoplasm] (Saccharomyces cerevisiae)

Modified Residues

Name

N6-acetyl-L-lysine at 17

Coordinate

PsiMod Name

N6-acetyl-L-lysine [MOD:00064]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.

Cross References

RefSeq

NP_733759.1

OpenTargets

ENSG00000146047

ENSEMBL

ENST00000274764, ENSP00000274764

HPA

ENSG00000146047-H2BC1

PRO

Q96A08

Pharos - Targets

Q96A08

GlyGen

Q96A08

PDB

3WKJ, 5GSU, 5GT3, 6BIY

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P41208 CETN2	3	CETN2 [cytosol] (R-HSA-380298) CETN2 [nucleoplasm] (R-HSA-4570490) polySUMO2,3-CETN2 [nucleoplasm] (R-HSA-4570486)	0.527	3
UniProt:Q9Y265 RUVBL1	1	RUVBL1 [nucleoplasm] (R-HSA-418323)	0.527	4
UniProt:P33993 MCM7	1	MCM7 [nucleoplasm] (R-HSA-68555)	0.527	4
UniProt:Q96L91 EP400	1	EP400 [nucleoplasm] (R-HSA-3321987)	0.527	4
UniProt:P49736 MCM2	1	MCM2 [nucleoplasm] (R-HSA-68557)	0.527	4
UniProt:Q14566 MCM6	1	MCM6 [nucleoplasm] (R-HSA-68553)	0.527	4
UniProt:P33991 MCM4	1	MCM4 [nucleoplasm] (R-HSA-68549)	0.527	4
UniProt:Q9Y230 RUVBL2	1	RUVBL2 [nucleoplasm] (R-HSA-418321)	0.527	3
UniProt:Q9Y5B9 SUPT16H	1	SUPT16H [nucleoplasm] (R-HSA-112415)	0.527	4
UniProt:Q92769 HDAC2	2	HDAC2 [nucleoplasm] (R-HSA-205135) monoSUMO1-K462-HDAC2 [nucleoplasm] (R-HSA-4615958)	0.527	3
UniProt:Q08945 SSRP1	1	SSRP1 [nucleoplasm] (R-HSA-65105)	0.527	4
UniProt:Q01831 XPC	5	monoSUMO1-K655-XPC [nucleoplasm] (R-HSA-4570458) Ub,SUMO,K63polyUb-XPC [nucleoplasm] (R-HSA-6790522) Ub,SUMO-XPC [nucleoplasm] (R-HSA-6790460) Ub-XPC [nucleoplasm] (R-HSA-6782944) XPC [nucleoplasm] (R-HSA-67441)	0.527	3
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.527	4
UniProt:O95619 YEATS4	1	YEATS4 [nucleoplasm] (R-HSA-3322940)	0.527	4