XPC binds RAD23 and CETN2

Stable Identifier
R-HSA-5691004
Type
Reaction
Species
Homo sapiens
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XPC is mutated in individuals with xeroderma pigmentosum from genetic Complementation Group C (XP-C). It forms a tight complex with RAD23B (HR23B) or, to a lesser extent, RAD23A (HR23A), two human homologs of yeast Rad23 (Masutani et al. 1994, Ng et al. 2003). CETN2 (centrin 2, CEN2) is also part of the XPC complex with RAD23 (Araki et al. 2001, Nishi et al. 2005).

Literature References
PubMed ID Title Journal Year
11279143 Centrosome protein centrin 2/caltractin 1 is part of the xeroderma pigmentosum group C complex that initiates global genome nucleotide excision repair

Kondoh, J, Takemura, M, Uchida, A, Masutani, C, Sugasawa, K, Hanaoka, F, Ohkuma, Y, Araki, M

J. Biol. Chem. 2001
15964821 Centrin 2 stimulates nucleotide excision repair by interacting with xeroderma pigmentosum group C protein

Okuda, Y, Mori, T, Watanabe, E, Iwai, S, Sugasawa, K, Hanaoka, F, Nishi, R, Masutani, C

Mol. Cell. Biol. 2005
8168482 Purification and cloning of a nucleotide excision repair complex involving the xeroderma pigmentosum group C protein and a human homologue of yeast RAD23

Takio, K, Bootsma, D, van der Spek, PJ, Enomoto, T, Sonoyama, T, Masutani, C, Ui, M, Yanagisawa, J, Sugasawa, K, Tanaka, K

EMBO J. 1994
12815074 A novel regulation mechanism of DNA repair by damage-induced and RAD23-dependent stabilization of xeroderma pigmentosum group C protein

Sugasawa, K, Bergink, S, Ng, JM, van der Horst, GT, Vrieling, H, Hoeijmakers, JH, Vermeulen, W

Genes Dev. 2003
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