Reactome | XPC binds RAD23 and CETN2

XPC binds RAD23 and CETN2

Stable Identifier

R-HSA-5691004

Type

Reaction

Species

Homo sapiens

Compartment

nucleoplasm

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XPC is mutated in individuals with xeroderma pigmentosum from genetic Complementation Group C (XP-C). It forms a tight complex with RAD23B (HR23B) or, to a lesser extent, RAD23A (HR23A), two human homologs of yeast Rad23 (Masutani et al. 1994, Ng et al. 2003). CETN2 (centrin 2, CEN2) is also part of the XPC complex with RAD23 (Araki et al. 2001, Nishi et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
11279143	Centrosome protein centrin 2/caltractin 1 is part of the xeroderma pigmentosum group C complex that initiates global genome nucleotide excision repair Kondoh, J, Takemura, M, Uchida, A, Masutani, C, Sugasawa, K, Hanaoka, F, Ohkuma, Y, Araki, M	J. Biol. Chem.	2001
15964821	Centrin 2 stimulates nucleotide excision repair by interacting with xeroderma pigmentosum group C protein Okuda, Y, Mori, T, Watanabe, E, Iwai, S, Sugasawa, K, Hanaoka, F, Nishi, R, Masutani, C	Mol. Cell. Biol.	2005
8168482	Purification and cloning of a nucleotide excision repair complex involving the xeroderma pigmentosum group C protein and a human homologue of yeast RAD23 Takio, K, Bootsma, D, van der Spek, PJ, Enomoto, T, Sonoyama, T, Masutani, C, Ui, M, Yanagisawa, J, Sugasawa, K, Tanaka, K	EMBO J.	1994
12815074	A novel regulation mechanism of DNA repair by damage-induced and RAD23-dependent stabilization of xeroderma pigmentosum group C protein Sugasawa, K, Bergink, S, Ng, JM, van der Horst, GT, Vrieling, H, Hoeijmakers, JH, Vermeulen, W	Genes Dev.	2003