Reactome | XPC binds RAD23 and CETN2

XPC binds RAD23 and CETN2

Stable Identifier

R-HSA-5691004

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

XPC is mutated in individuals with xeroderma pigmentosum from genetic Complementation Group C (XP-C). It forms a tight complex with RAD23B (HR23B) or, to a lesser extent, RAD23A (HR23A), two human homologs of yeast Rad23 (Masutani et al. 1994, Ng et al. 2003). CETN2 (centrin 2, CEN2) is also part of the XPC complex with RAD23 (Araki et al. 2001, Nishi et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
15964821	Centrin 2 stimulates nucleotide excision repair by interacting with xeroderma pigmentosum group C protein Nishi, R, Okuda, Y, Watanabe, E, Mori, T, Iwai, S, Masutani, C, Sugasawa, K, Hanaoka, F	Mol. Cell. Biol.	2005
11279143	Centrosome protein centrin 2/caltractin 1 is part of the xeroderma pigmentosum group C complex that initiates global genome nucleotide excision repair Araki, M, Masutani, C, Takemura, M, Uchida, A, Sugasawa, K, Kondoh, J, Ohkuma, Y, Hanaoka, F	J. Biol. Chem.	2001
8168482	Purification and cloning of a nucleotide excision repair complex involving the xeroderma pigmentosum group C protein and a human homologue of yeast RAD23 Masutani, C, Sugasawa, K, Yanagisawa, J, Sonoyama, T, Ui, M, Enomoto, T, Takio, K, Tanaka, K, van der Spek, PJ, Bootsma, D	EMBO J.	1994
12815074	A novel regulation mechanism of DNA repair by damage-induced and RAD23-dependent stabilization of xeroderma pigmentosum group C protein Ng, JM, Vermeulen, W, van der Horst, GT, Bergink, S, Sugasawa, K, Vrieling, H, Hoeijmakers, JH	Genes Dev.	2003