Reactome | AcK13-HIST1H2BO [nucleoplasm]

AcK13-HIST1H2BO [nucleoplasm]

Stable Identifier

R-HSA-4568712

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

Expand all

Chromatin organization (Homo sapiens)

- Chromatin modifying enzymes (Homo sapiens)
  - HATs acetylate histones (Homo sapiens)
    - CREBBP acetylates histone H2B, H3, H4 (Homo sapiens)
      - AcK-histone H2B, H3, H4 [nucleoplasm] (Homo sapiens)
        
        AcK13-replicative histone H2B [nucleoplasm] (Homo sapiens)
        
        Ack13-replicative histone HIST1H2B [nucleoplasm] (Homo sapiens)
        
        AcK13-HIST1H2BO [nucleoplasm] (Homo sapiens)
    - EP300 acetylates histone H2A, H2B, H3, H4 (Homo sapiens)
      - AcK-histone H2A, H2B, H3, H4 [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-HIST1H2BO [nucleoplasm] (Homo sapiens)
        
        AcK13-HIST1H2BO [nucleoplasm] (Homo sapiens)
  - HDACs deacetylate histones (Homo sapiens)
    - HDAC10 deacetylates histone (Homo sapiens)
      - Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-HIST1H2BO [nucleoplasm] (Homo sapiens)
        
        AcK13-HIST1H2BO [nucleoplasm] (Homo sapiens)
    - HDAC1:2-containing complex deacetylate histones (Homo sapiens)
      - Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-HIST1H2BO [nucleoplasm] (Homo sapiens)
        
        AcK13-HIST1H2BO [nucleoplasm] (Homo sapiens)
    - HDAC3 containing complexes deacetylate histone (Homo sapiens)
      - Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-HIST1H2BO [nucleoplasm] (Homo sapiens)
        
        AcK13-HIST1H2BO [nucleoplasm] (Homo sapiens)
    - HDAC8 deacetylates histones (Homo sapiens)
      - Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-HIST1H2BO [nucleoplasm] (Homo sapiens)
        
        AcK13-HIST1H2BO [nucleoplasm] (Homo sapiens)

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - HCMV Infection (Homo sapiens)
      - HCMV Early Events (Homo sapiens)
        
        Activation of Latent HCMV Genome (Homo sapiens)
        
        Transcriptionally Active HCMV Genome [nucleoplasm] (Homo sapiens)
        
        Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-HIST1H2BO [nucleoplasm] (Homo sapiens)
        
        AcK13-HIST1H2BO [nucleoplasm] (Homo sapiens)
        
        Delayed Early (DE) Gene Expression (Homo sapiens)
        
        Transcriptionally Active HCMV Genome [nucleoplasm] (Homo sapiens)
        
        Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-HIST1H2BO [nucleoplasm] (Homo sapiens)
        
        AcK13-HIST1H2BO [nucleoplasm] (Homo sapiens)
        
        Immediate Early (IE) Gene Expression (Homo sapiens)
        
        Transcriptionally Active HCMV Genome [nucleoplasm] (Homo sapiens)
        
        Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-HIST1H2BO [nucleoplasm] (Homo sapiens)
        
        AcK13-HIST1H2BO [nucleoplasm] (Homo sapiens)
        
        Transcriptional Activation of the HCMV Genome (Homo sapiens)
        
        Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-HIST1H2BO [nucleoplasm] (Homo sapiens)
        
        AcK13-HIST1H2BO [nucleoplasm] (Homo sapiens)
        
        Transcriptionally Active HCMV Genome [nucleoplasm] (Homo sapiens)
        
        Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-HIST1H2BO [nucleoplasm] (Homo sapiens)
        
        AcK13-HIST1H2BO [nucleoplasm] (Homo sapiens)
      - HCMV Late Events (Homo sapiens)
        
        Late (L) Gene Expression (Homo sapiens)
        
        Transcriptionally Active HCMV Genome [nucleoplasm] (Homo sapiens)
        
        Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-HIST1H2BO [nucleoplasm] (Homo sapiens)
        
        AcK13-HIST1H2BO [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P23527 H2BC17

Gene Names

H2BC17, H2BFH, H2BFN, HIST1H2BO

Chain

initiator methionine:, chain:2-126

Reference Genes

BioGPS Gene:8348 H2BC17

CTD Gene:8348 H2BC17

dbSNP Gene:8348 H2BC17

ENSEMBL:ENSG00000274641 HIST1H2BO

ENSEMBL_homo_sapiens_GENE:ENSG00000274641.2 H2BC17

HGNC:4758 H2BC17

KEGG Gene (Homo sapiens):8348 H2BC17

Monarch:8348 H2BC17

NCBI Gene:8348 H2BC17

OMIM:602808 H2BC17

UCSC:P23527 H2BC17

Reference Transcript

RefSeq:NM_003527.4 H2BC17

Other Identifiers

11742176_s_at

17005880

214540_PM_at

214540_at

2900118

2900119

2900120

8117614

8348

ADDON002745.hg

A_23_P59069

GO:0000786

GO:0003677

GO:0005198

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005829

GO:0006325

GO:0006334

GO:0030527

GO:0043226

GO:0043229

GO:0046982

GO:0065003

HMNXSV003007889

Hs.151506.0.S1_3p_at

Hs.151506.0.S1_3p_x_at

ILMN_1739076

PH_hs_0036083

TC06000270.hg

Participates

as a member of

Other forms of this molecule

Ub-HIST1H2BO [nucleoplasm]

AcK-HIST1H2BO [nucleoplasm]

HIST1H2BO [extracellular region]

AcK21-HIST1H2BO [nucleoplasm]

AcK16-HIST1H2BO [nucleoplasm]

AcK6-HIST1H2BO [nucleoplasm]

Ub-121-HIST1H2BO [nucleoplasm]

HIST1H2BO [nucleoplasm]

Inferred To

H2Bv1 [nucleoplasm] (Dictyostelium discoideum)

H2B-VIII [nucleoplasm] (Gallus gallus)

His2B [nucleoplasm] (Drosophila melanogaster)

H2Bv2 [nucleoplasm] (Dictyostelium discoideum)

htb1 [nucleoplasm] (Schizosaccharomyces pombe)

AcK13-HIST1H2BO [nucleoplasm] (Bos taurus)

Homologues of AcK13-HIST1H2BB [nucleoplasm] (Dictyostelium discoideum)

Homologues of AcK13-HIST1H2BB [nucleoplasm] (Gallus gallus)

Homologues of AcK13-HIST1H2BB [nucleoplasm] (Plasmodium falciparum)

Homologues of AcK13-HIST1H2BB [nucleoplasm] (Saccharomyces cerevisiae)

h2bc11 [nucleoplasm] (Xenopus tropicalis)

H2B-V [nucleoplasm] (Gallus gallus)

AcK13-HIST1H2BB [nucleoplasm] (Plasmodium falciparum)

H2Bv3 [nucleoplasm] (Dictyostelium discoideum)

H2B-VII [nucleoplasm] (Gallus gallus)

H2BC3 [nucleoplasm] (Canis familiaris)

hist2h2l [nucleoplasm] (Danio rerio)

HTB1 [nucleoplasm] (Saccharomyces cerevisiae)

HTB2 [nucleoplasm] (Saccharomyces cerevisiae)

Modified Residues

Name

N6-acetyl-L-lysine at 13

Coordinate

PsiMod Name

N6-acetyl-L-lysine [MOD:00064]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.

Cross References

RefSeq

NP_003518.2

OpenTargets

ENSG00000274641

GeneCards

P23527

HPA

ENSG00000274641-H2BC17

Ensembl

ENST00000616182, ENSP00000477527, ENSG00000274641

PRO

P23527

Pharos - Targets

P23527

PDB

7WLP

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q01831 XPC	5	XPC [nucleoplasm] (R-HSA-67441) Ub-XPC [nucleoplasm] (R-HSA-6782944) Ub,SUMO-XPC [nucleoplasm] (R-HSA-6790460) Ub,SUMO,K63polyUb-XPC [nucleoplasm] (R-HSA-6790522) monoSUMO1-K655-XPC [nucleoplasm] (R-HSA-4570458)	0.527	3
UniProt:P16104 H2AFX	7	Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317) H2AFX [nucleoplasm] (R-HSA-56151) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-S140-H2AFX [nucleoplasm] (R-HSA-75170) K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) H2AFX [extracellular region] (R-HSA-977583)	0.527	3
UniProt:Q8NAV1 PRPF38A	1	PRPF38A [nucleoplasm] (R-HSA-8867897)	0.508	2