Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
HIST1H2BD [extracellular region]
Stable Identifier
R-HSA-977561
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Histone H2B.b
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
FXIIa activates plasma kallikrein-kinin system (Homo sapiens)
factor XII + polyanionic activator -> factor XII:polyanionic activator (in plasma) (Homo sapiens)
FXII:polyanionic activator [extracellular region] (Homo sapiens)
polyanionic activators of FXII [extracellular region] (Homo sapiens)
Chromatin (decondensed) [extracellular region] (Homo sapiens)
Nucleosome (citrullinated, deacetylated) [extracellular region] (Homo sapiens)
Histone H2B [extracellular region] (Homo sapiens)
HIST1H2BD [extracellular region] (Homo sapiens)
polyanionic activators of FXII [extracellular region] (Homo sapiens)
Chromatin (decondensed) [extracellular region] (Homo sapiens)
Nucleosome (citrullinated, deacetylated) [extracellular region] (Homo sapiens)
Histone H2B [extracellular region] (Homo sapiens)
HIST1H2BD [extracellular region] (Homo sapiens)
factor XII:polyanionic activator -> factor XIIa + polyanionic activator (autocatalysis) (Homo sapiens)
FXII:polyanionic activator [extracellular region] (Homo sapiens)
polyanionic activators of FXII [extracellular region] (Homo sapiens)
Chromatin (decondensed) [extracellular region] (Homo sapiens)
Nucleosome (citrullinated, deacetylated) [extracellular region] (Homo sapiens)
Histone H2B [extracellular region] (Homo sapiens)
HIST1H2BD [extracellular region] (Homo sapiens)
polyanionic activators of FXII [extracellular region] (Homo sapiens)
Chromatin (decondensed) [extracellular region] (Homo sapiens)
Nucleosome (citrullinated, deacetylated) [extracellular region] (Homo sapiens)
Histone H2B [extracellular region] (Homo sapiens)
HIST1H2BD [extracellular region] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Amyloid fiber formation (Homo sapiens)
Serum amyloid P binds DNA and chromatin (Homo sapiens)
Double-stranded DNA and chromatin [extracellular region] (Homo sapiens)
Chromatin [extracellular region] (Homo sapiens)
Nucleosome (Deacetylated) [extracellular region] (Homo sapiens)
Histone H2B [extracellular region] (Homo sapiens)
HIST1H2BD [extracellular region] (Homo sapiens)
Serum amyloid P-component pentamer:Double-stranded DNA [extracellular region] (Homo sapiens)
Double-stranded DNA and chromatin [extracellular region] (Homo sapiens)
Chromatin [extracellular region] (Homo sapiens)
Nucleosome (Deacetylated) [extracellular region] (Homo sapiens)
Histone H2B [extracellular region] (Homo sapiens)
HIST1H2BD [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P58876 H2BC5
Gene Names
H2BC5, H2BFB, HIRIP2, HIST1H2BD
Chain
initiator methionine:1, chain:2-126
Reference Genes
BioGPS Gene:3017 H2BC5
COSMIC - genes:HIST1H2BD H2BC5
CTD Gene:3017 H2BC4
dbSNP Gene:3017 H2BC5
ENSEMBL:ENSG00000158373 H2BC5
HGNC:4747 H2BC5
KEGG:hsa:3017 H2BC5
Monarch:3017 H2BC5
NCBI Gene:3017 H2BC5
OMIM:602799 H2BC5
UCSC:P58876 H2BC5
Reference Transcript
RefSeq:NM_138720.2 H2BC5
RefSeq:NM_021063.4 H2BC5
RefSeq:XM_005249039.5 H2BC5
Other Identifiers
11724021_at
11728152_a_at
11728153_x_at
17005573
209911_PM_x_at
209911_x_at
222067_PM_x_at
222067_x_at
2899177
2899178
2899179
2899181
2899182
2899183
2899184
2899185
2899186
2899187
2899188
2899189
2899193
2947034
3017
38576_at
8117382
88155_at
ADDON002904.hg
ADDON002918.hg
A_24_P146211
GE63182
GO:0000786
GO:0003677
GO:0005198
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005829
GO:0030527
GO:0046982
GO:0070062
HMNXSV003000583
HMNXSV003001089
HMNXSV003004994
Hs.180779.1.S1_3p_at
ILMN_1651496
ILMN_1758623
ILMN_1777405
PH_hs_0010698
TC06000169.hg
g12803984_3p_at
g12803984_3p_x_at
Participates
as a candidate of
Histone H2B [extracellular region] (Homo sapiens)
Other forms of this molecule
Ub-HIST1H2BD [nucleoplasm]
AcK-HIST1H2BD [nucleoplasm]
AcK16-HIST1H2BD [nucleoplasm]
AcK6-HIST1H2BD [nucleoplasm]
AcK21-HIST1H2BD [nucleoplasm]
AcK13-HIST1H2BD [nucleoplasm]
Ub-121-HIST1H2BD [nucleoplasm]
HIST1H2BD [nucleoplasm]
Inferred To
h2bc11 [extracellular region]
(Xenopus tropicalis)
LOC119877882 [extracellular region]
(Canis familiaris)
HIST1H2BC [extracellular region]
(Bos taurus)
H2B-VI [extracellular region]
(Gallus gallus)
Hist1h2bq [extracellular region]
(Rattus norvegicus)
H2BC5 [extracellular region]
(Sus scrofa)
hist2h2l [extracellular region]
(Danio rerio)
Cross References
RefSeq
NP_619790.1
,
XP_005249096.2
,
NP_066407.1
ENSEMBL
ENST00000289316
,
ENSP00000289316
,
ENSP00000367008
,
ENSG00000158373
,
ENST00000377777
OpenTargets
ENSG00000158373
GeneCards
H2BC5
HPA
ENSG00000158373-H2BC5
PRO
P58876
Pharos - Targets
P58876
GlyGen
P58876
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P16104 H2AX
8
H2AFX [nucleoplasm]
(R-HSA-56151)
p-Y143-H2AFX [nucleoplasm]
(R-HSA-5683942)
p-S140,Y143-H2AFX [nucleoplasm]
(R-HSA-5683953)
p-S140-H2AFX [nucleoplasm]
(R-HSA-75170)
K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm]
(R-HSA-5682847)
H2AFX [extracellular region]
(R-HSA-977583)
Me2sR4-H2AFX [nucleoplasm]
(R-HSA-5218317)
acK H2AFX [nucleoplasm]
(R-HSA-9943854)
0.669
3
UniProt:Q01831 XPC
5
XPC [nucleoplasm]
(R-HSA-67441)
Ub-XPC [nucleoplasm]
(R-HSA-6782944)
Ub,SUMO-XPC [nucleoplasm]
(R-HSA-6790460)
Ub,SUMO,K63polyUb-XPC [nucleoplasm]
(R-HSA-6790522)
monoSUMO1-K655-XPC [nucleoplasm]
(R-HSA-4570458)
0.527
3
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text