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Ub-121-HIST1H2BD [nucleoplasm]
Stable Identifier
R-HSA-3364025
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Histone H2B.b K121ub
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Formation of the beta-catenin:TCF transactivating complex (Homo sapiens)
SET1 complex trimethylates H3K4 at the MYC gene (Homo sapiens)
MYC gene: H2B K121ub nucleosome [nucleoplasm] (Homo sapiens)
Nucleosome with H2BK121ub [nucleoplasm] (Homo sapiens)
Histone H2B K121ub [nucleoplasm] (Homo sapiens)
Ub-121-HIST1H2BD [nucleoplasm] (Homo sapiens)
MYC gene:H2B K121ub H3K4me3 nucleosome [nucleoplasm] (Homo sapiens)
Nucleosome with H2BK121ub and H3K4me3 [nucleoplasm] (Homo sapiens)
Histone H2B K121ub [nucleoplasm] (Homo sapiens)
Ub-121-HIST1H2BD [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P58876 H2BC5
Gene Names
H2BC5, H2BFB, HIRIP2, HIST1H2BD
Chain
initiator methionine:, chain:2-126
Reference Genes
BioGPS Gene:3017 H2BC5
COSMIC (genes):HIST1H2BD H2BC5
CTD Gene:3017 H2BC5
dbSNP Gene:3017 H2BC5
ENSEMBL:ENSG00000158373 HIST1H2BD
HGNC:4747 H2BC5
KEGG:hsa:3017 H2BC5
Monarch:3017 H2BC5
NCBI Gene:3017 H2BC5
OMIM:602799 H2BC5
UCSC:P58876 H2BC5
Reference Transcript
RefSeq:NM_138720.2 H2BC5
RefSeq:NM_021063.3 H2BC5
RefSeq:XM_005249039.3 H2BC5
Other Identifiers
11724021_at
11728152_a_at
11728153_x_at
17005573
209911_PM_x_at
209911_x_at
222067_PM_x_at
222067_x_at
2899178
2899179
2899193
2947034
3017
38576_at
8117382
88155_at
ADDON002904.hg
ADDON002918.hg
A_24_P146211
GE63182
GO:0000786
GO:0003674
GO:0003677
GO:0005198
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005829
GO:0030527
GO:0043226
GO:0043229
GO:0046982
GO:0070062
HMNXSV003000583
HMNXSV003001089
Hs.180779.1.S1_3p_at
ILMN_1651496
ILMN_1758623
ILMN_1777405
PH_hs_0010698
TC06000169.hg
g12803984_3p_at
g12803984_3p_x_at
Participates
as a candidate of
Histone H2B K121ub [nucleoplasm] (Homo sapiens)
Other forms of this molecule
Ub-HIST1H2BD [nucleoplasm]
AcK-HIST1H2BD [nucleoplasm]
HIST1H2BD [extracellular region]
AcK16-HIST1H2BD [nucleoplasm]
AcK6-HIST1H2BD [nucleoplasm]
AcK21-HIST1H2BD [nucleoplasm]
AcK13-HIST1H2BD [nucleoplasm]
HIST1H2BD [nucleoplasm]
Inferred To
H2Bv1 [nucleoplasm]
(Dictyostelium discoideum)
H2B-VIII [nucleoplasm]
(Gallus gallus)
His2B [nucleoplasm]
(Drosophila melanogaster)
H2Bv2 [nucleoplasm]
(Dictyostelium discoideum)
htb1 [nucleoplasm]
(Schizosaccharomyces pombe)
Ub-121-HIST1H2BD [nucleoplasm]
(Bos taurus)
Ub-121-HIST1H2BK [nucleoplasm]
(Danio rerio)
Ub-121-HIST1H2BK [nucleoplasm]
(Plasmodium falciparum)
h2bc11 [nucleoplasm]
(Xenopus tropicalis)
HIST1H2B5L [nucleoplasm]
(Gallus gallus)
H2B-V [nucleoplasm]
(Gallus gallus)
si:ch211-113a14.22 [nucleoplasm]
(Danio rerio)
LOC100498553 [nucleoplasm]
(Xenopus tropicalis)
LOC116411635 [nucleoplasm]
(Xenopus tropicalis)
H2Bv3 [nucleoplasm]
(Dictyostelium discoideum)
H2B-VII [nucleoplasm]
(Gallus gallus)
Homologues of Ub-121-HIST1H2BK [nucleoplasm]
(Danio rerio)
Homologues of Ub-121-HIST1H2BK [nucleoplasm]
(Dictyostelium discoideum)
Homologues of Ub-121-HIST1H2BK [nucleoplasm]
(Gallus gallus)
Homologues of Ub-121-HIST1H2BK [nucleoplasm]
(Plasmodium falciparum)
Homologues of Ub-121-HIST1H2BK [nucleoplasm]
(Saccharomyces cerevisiae)
Homologues of Ub-121-HIST1H2BK [nucleoplasm]
(Xenopus tropicalis)
H2B-I [nucleoplasm]
(Gallus gallus)
hist2h2l [nucleoplasm]
(Danio rerio)
HTB1 [nucleoplasm]
(Saccharomyces cerevisiae)
LOC570661 [nucleoplasm]
(Danio rerio)
HTB2 [nucleoplasm]
(Saccharomyces cerevisiae)
h2bc21 [nucleoplasm]
(Xenopus tropicalis)
Modified Residues
Name
ubiquitinylated lysine at 121
Coordinate
121
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
NP_619790.1
,
NP_066407.1
,
XP_005249096.1
ENSEMBL
ENST00000377777
,
ENSP00000289316
,
ENSP00000367008
,
ENST00000289316
OpenTargets
ENSG00000158373
HPA
ENSG00000158373-H2BC5
PRO
P58876
Pharos - Targets
P58876
GlyGen
P58876
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P16104 H2AFX
7
H2AFX [nucleoplasm]
(R-HSA-56151)
p-Y143-H2AFX [nucleoplasm]
(R-HSA-5683942)
p-S140,Y143-H2AFX [nucleoplasm]
(R-HSA-5683953)
p-S140-H2AFX [nucleoplasm]
(R-HSA-75170)
K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm]
(R-HSA-5682847)
H2AFX [extracellular region]
(R-HSA-977583)
Me2sR4-H2AFX [nucleoplasm]
(R-HSA-5218317)
0.669
3
UniProt:Q01831 XPC
5
monoSUMO1-K655-XPC [nucleoplasm]
(R-HSA-4570458)
Ub,SUMO,K63polyUb-XPC [nucleoplasm]
(R-HSA-6790522)
Ub,SUMO-XPC [nucleoplasm]
(R-HSA-6790460)
Ub-XPC [nucleoplasm]
(R-HSA-6782944)
XPC [nucleoplasm]
(R-HSA-67441)
0.527
3
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