Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Ub-121-HIST1H2BO [nucleoplasm]
Stable Identifier
R-HSA-3364033
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Histone H2B.n K121ub
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Formation of the beta-catenin:TCF transactivating complex (Homo sapiens)
SET1 complex trimethylates H3K4 at the MYC gene (Homo sapiens)
MYC gene: H2B K121ub nucleosome [nucleoplasm] (Homo sapiens)
Nucleosome with H2BK121ub [nucleoplasm] (Homo sapiens)
Histone H2B K121ub [nucleoplasm] (Homo sapiens)
Ub-121-HIST1H2BO [nucleoplasm] (Homo sapiens)
MYC gene:H2B K121ub H3K4me3 nucleosome [nucleoplasm] (Homo sapiens)
Nucleosome with H2BK121ub and H3K4me3 [nucleoplasm] (Homo sapiens)
Histone H2B K121ub [nucleoplasm] (Homo sapiens)
Ub-121-HIST1H2BO [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P23527 H2BC17
Gene Names
H2BC17, H2BFH, H2BFN, HIST1H2BO
Chain
initiator methionine:, chain:2-126
Reference Genes
BioGPS Gene:8348 H2BC17
CTD Gene:8348 H2BC17
dbSNP Gene:8348 H2BC17
ENSEMBL:ENSG00000274641 HIST1H2BO
ENSEMBL_homo_sapiens_GENE:ENSG00000274641.2 H2BC17
HGNC:4758 H2BC17
KEGG Gene (Homo sapiens):8348 H2BC17
Monarch:8348 H2BC17
NCBI Gene:8348 H2BC17
OMIM:602808 H2BC17
UCSC:P23527 H2BC17
Reference Transcript
RefSeq:NM_003527.4 H2BC17
Other Identifiers
11742176_s_at
17005880
214540_PM_at
214540_at
2900118
2900119
2900120
8117614
8348
ADDON002745.hg
A_23_P59069
GO:0000786
GO:0003677
GO:0005198
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005829
GO:0006325
GO:0006334
GO:0030527
GO:0043226
GO:0043229
GO:0046982
GO:0065003
HMNXSV003007889
Hs.151506.0.S1_3p_at
Hs.151506.0.S1_3p_x_at
ILMN_1739076
PH_hs_0036083
TC06000270.hg
Participates
as a candidate of
Histone H2B K121ub [nucleoplasm] (Homo sapiens)
Other forms of this molecule
Ub-HIST1H2BO [nucleoplasm]
AcK-HIST1H2BO [nucleoplasm]
HIST1H2BO [extracellular region]
AcK13-HIST1H2BO [nucleoplasm]
AcK21-HIST1H2BO [nucleoplasm]
AcK16-HIST1H2BO [nucleoplasm]
AcK6-HIST1H2BO [nucleoplasm]
HIST1H2BO [nucleoplasm]
Inferred To
H2Bv1 [nucleoplasm]
(Dictyostelium discoideum)
H2B-VIII [nucleoplasm]
(Gallus gallus)
His2B [nucleoplasm]
(Drosophila melanogaster)
H2Bv2 [nucleoplasm]
(Dictyostelium discoideum)
htb1 [nucleoplasm]
(Schizosaccharomyces pombe)
Homologues of Ub-121-HIST1H2BB [nucleoplasm]
(Gallus gallus)
Ub-121-HIST1H2BK [nucleoplasm]
(Plasmodium falciparum)
h2bc11 [nucleoplasm]
(Xenopus tropicalis)
H2B-V [nucleoplasm]
(Gallus gallus)
H2Bv3 [nucleoplasm]
(Dictyostelium discoideum)
H2B-VII [nucleoplasm]
(Gallus gallus)
Homologues of Ub-121-HIST1H2BK [nucleoplasm]
(Dictyostelium discoideum)
Homologues of Ub-121-HIST1H2BK [nucleoplasm]
(Plasmodium falciparum)
Homologues of Ub-121-HIST1H2BK [nucleoplasm]
(Saccharomyces cerevisiae)
hist2h2l [nucleoplasm]
(Danio rerio)
HTB1 [nucleoplasm]
(Saccharomyces cerevisiae)
HTB2 [nucleoplasm]
(Saccharomyces cerevisiae)
Ub-121-HIST1H2BO [nucleoplasm]
(Bos taurus)
Modified Residues
Name
ubiquitinylated lysine at 121
Coordinate
121
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
NP_003518.2
OpenTargets
ENSG00000274641
GeneCards
P23527
HPA
ENSG00000274641-H2BC17
Ensembl
ENST00000616182
,
ENSP00000477527
,
ENSG00000274641
PRO
P23527
Pharos - Targets
P23527
PDB
7WLP
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q01831 XPC
5
XPC [nucleoplasm]
(R-HSA-67441)
Ub-XPC [nucleoplasm]
(R-HSA-6782944)
Ub,SUMO-XPC [nucleoplasm]
(R-HSA-6790460)
Ub,SUMO,K63polyUb-XPC [nucleoplasm]
(R-HSA-6790522)
monoSUMO1-K655-XPC [nucleoplasm]
(R-HSA-4570458)
0.527
3
UniProt:P16104 H2AFX
7
Me2sR4-H2AFX [nucleoplasm]
(R-HSA-5218317)
H2AFX [nucleoplasm]
(R-HSA-56151)
p-Y143-H2AFX [nucleoplasm]
(R-HSA-5683942)
p-S140,Y143-H2AFX [nucleoplasm]
(R-HSA-5683953)
p-S140-H2AFX [nucleoplasm]
(R-HSA-75170)
K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm]
(R-HSA-5682847)
H2AFX [extracellular region]
(R-HSA-977583)
0.527
3
UniProt:Q8NAV1 PRPF38A
1
PRPF38A [nucleoplasm]
(R-HSA-8867897)
0.508
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text