Reactome | Ub-Misfolded CETN1 [cytosol]

Ub-Misfolded CETN1 [cytosol]

Stable Identifier

R-HSA-9641110

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q12798 CETN1

Gene Names

CETN1, CEN1, CETN

Chain

chain:1-172

Reference Genes

BioGPS Gene:1068 CETN1

COSMIC (genes):CETN1 CETN1

CTD Gene:1068 CETN1

dbSNP Gene:1068 CETN1

ENSEMBL:ENSG00000177143 CETN1

ENSEMBL_homo_sapiens_GENE:ENSG00000177143.5 CETN1

HGNC:1866 CETN1

KEGG Gene (Homo sapiens):1068 CETN1

Monarch:1068 CETN1

NCBI Gene:1068 CETN1

OMIM:603187 CETN1

UCSC:Q12798 CETN1

Reference Transcript

RefSeq:NM_004066.2 CETN1

Other Identifiers

1068

11743876_at

16850461

207209_PM_at

207209_at

35496_at

3775805

3775806

3775807

52197_at

8019828

ADDON002473.hg

A_14_P102770

A_14_P200502

GE58863

GO:0000278

GO:0000922

GO:0005509

GO:0005515

GO:0005737

GO:0005813

GO:0005814

GO:0005815

GO:0005829

GO:0005856

GO:0005929

GO:0006281

GO:0006289

GO:0007010

GO:0007049

GO:0007099

GO:0008017

GO:0008092

GO:0031683

GO:0032391

GO:0032795

GO:0034605

GO:0042995

GO:0043226

GO:0046872

GO:0051301

HMNXSV003040393

HMNXSV003057610

ILMN_1768624

ILMN_2132309

PH_hs_0006853

TC18000004.hg

U03270_at

g4757973_3p_at

Participates

as a member of

Ub-Misfolded cilia proteins [cytosol] (Homo sapiens)

Other forms of this molecule

PolyUb-Misfolded CETN1 [late endosome lumen]

CETN1 [cilium]

Misfolded CETN1 [cilium]

Misfolded CETN1 [cytosol]

PolyUb-Misfolded CETN1 [cytosol]

PolyUb-Misfolded CETN1 [lysosomal lumen]

Inferred To

Dmel\CG13526 [cytosol] (Drosophila melanogaster)

Dmel\CG17493 [cytosol] (Drosophila melanogaster)

Homologues of Ub-Misfolded CETN1 [cytosol] (Caenorhabditis elegans)

Homologues of Ub-Misfolded CETN1 [cytosol] (Dictyostelium discoideum)

Homologues of Ub-Misfolded CETN1 [cytosol] (Drosophila melanogaster)

Homologues of Ub-Misfolded CETN1 [cytosol] (Plasmodium falciparum)

CG15158 [cytosol] (Drosophila melanogaster)

Ub-Misfolded CETN1 [cytosol] (Bos taurus)

Ub-Misfolded CETN1 [cytosol] (Caenorhabditis elegans)

Ub-Misfolded CETN1 [cytosol] (Dictyostelium discoideum)

Ub-Misfolded CETN1 [cytosol] (Mus musculus)

Ub-Misfolded CETN1 [cytosol] (Plasmodium falciparum)

Ub-Misfolded CETN1 [cytosol] (Sus scrofa)

CETN1 [cytosol] (Canis familiaris)

CETN1 [cytosol] (Gallus gallus)

Cetn1 [cytosol] (Rattus norvegicus)

Modified Residues

Name

ubiquitinylated lysine (K63-Ub [cytosol]) at unknown position

Modification

K63-Ub [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_004057.1

OpenTargets

ENSG00000177143

GeneCards

Q12798

HPA

ENSG00000177143-CETN1

Ensembl

ENST00000327228, ENSP00000319052, ENSG00000177143

PRO

Q12798

Pharos - Targets

Q12798

HMDB Protein

HMDBP07582

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P29762 CRABP1	1	SUMO-K-CRABP1 [cytosol] (R-HSA-5334807)	0.527	2
UniProt:Q16513 PKN2	2	p-T816-PKN2 [cytosol] (R-HSA-5623652) PKN2 [cytosol] (R-HSA-5623612)	0.527	4
UniProt:Q9Y5B9 SUPT16H	1	SUPT16H [nucleoplasm] (R-HSA-112415)	0.527	3
UniProt:Q01831 XPC	5	XPC [nucleoplasm] (R-HSA-67441) Ub-XPC [nucleoplasm] (R-HSA-6782944) Ub,SUMO-XPC [nucleoplasm] (R-HSA-6790460) Ub,SUMO,K63polyUb-XPC [nucleoplasm] (R-HSA-6790522) monoSUMO1-K655-XPC [nucleoplasm] (R-HSA-4570458)	0.527	5
UniProt:Q9P0V3 SH3BP4	1	SH3BP4 [cytosol] (R-HSA-8866227)	0.527	2
UniProt:P41208 CETN2	3	CETN2 [cytosol] (R-HSA-380298) CETN2 [nucleoplasm] (R-HSA-4570490) polySUMO2,3-CETN2 [nucleoplasm] (R-HSA-4570486)	0.527	4
UniProt:P16104 H2AFX	7	Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317) H2AFX [nucleoplasm] (R-HSA-56151) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-S140-H2AFX [nucleoplasm] (R-HSA-75170) K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) H2AFX [extracellular region] (R-HSA-977583)	0.527	3
UniProt:Q14999 CUL7	1	CUL7 [cytosol] (R-HSA-535534)	0.527	2
UniProt:Q15672 TWIST1	1	TWIST1 [nucleoplasm] (R-HSA-445442)	0.527	3

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