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Ub-HIST1H2BO [nucleoplasm]
Stable Identifier
R-HSA-6782549
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
HIST1H2BO, Histone H2B.n
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
Ub-specific processing proteases (Homo sapiens)
USP3,SAGA deubiquitinate Histone H2A,H2B (Homo sapiens)
USP3,SAGA:Ub-histone H2A, Ub-histone H2B [nucleoplasm] (Homo sapiens)
Ub-histone H2A, Ub-histone H2B [nucleoplasm] (Homo sapiens)
Ub-histone H2B [nucleoplasm] (Homo sapiens)
Ub-histone HIST1H2B [nucleoplasm] (Homo sapiens)
Ub-HIST1H2BO [nucleoplasm] (Homo sapiens)
USP49 deubiquitinates H2B (Homo sapiens)
USP49:Ub-histone H2B [nucleoplasm] (Homo sapiens)
Ub-histone H2B [nucleoplasm] (Homo sapiens)
Ub-histone HIST1H2B [nucleoplasm] (Homo sapiens)
Ub-HIST1H2BO [nucleoplasm] (Homo sapiens)
Protein ubiquitination (Homo sapiens)
E3 ubiquitin ligases ubiquitinate target proteins (Homo sapiens)
RNF20:RNF40 monoubiquitinates Histone H2B (Homo sapiens)
Ub-histone HIST1H2B [nucleoplasm] (Homo sapiens)
Ub-HIST1H2BO [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P23527 H2BC17
Gene Names
H2BC17, H2BFH, H2BFN, HIST1H2BO
Chain
initiator methionine:, chain:2-126
Reference Genes
BioGPS Gene:8348 H2BC17
CTD Gene:8348 H2BC17
dbSNP Gene:8348 H2BC17
ENSEMBL:ENSG00000274641 HIST1H2BO
ENSEMBL_homo_sapiens_GENE:ENSG00000274641.2 H2BC17
HGNC:4758 H2BC17
KEGG Gene (Homo sapiens):8348 H2BC17
Monarch:8348 H2BC17
NCBI Gene:8348 H2BC17
OMIM:602808 H2BC17
UCSC:P23527 H2BC17
Reference Transcript
RefSeq:NM_003527.4 H2BC17
Other Identifiers
11742176_s_at
17005880
214540_PM_at
214540_at
2900118
2900119
2900120
8117614
8348
ADDON002745.hg
A_23_P59069
GO:0000786
GO:0003677
GO:0005198
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005829
GO:0006325
GO:0006334
GO:0030527
GO:0043226
GO:0043229
GO:0046982
GO:0065003
HMNXSV003007889
Hs.151506.0.S1_3p_at
Hs.151506.0.S1_3p_x_at
ILMN_1739076
PH_hs_0036083
TC06000270.hg
Participates
as a member of
Ub-histone HIST1H2B [nucleoplasm] (Homo sapiens)
Other forms of this molecule
AcK-HIST1H2BO [nucleoplasm]
HIST1H2BO [extracellular region]
AcK13-HIST1H2BO [nucleoplasm]
AcK21-HIST1H2BO [nucleoplasm]
AcK16-HIST1H2BO [nucleoplasm]
AcK6-HIST1H2BO [nucleoplasm]
Ub-121-HIST1H2BO [nucleoplasm]
HIST1H2BO [nucleoplasm]
Inferred To
H2Bv1 [nucleoplasm]
(Dictyostelium discoideum)
H2B-VIII [nucleoplasm]
(Gallus gallus)
His2B [nucleoplasm]
(Drosophila melanogaster)
H2Bv2 [nucleoplasm]
(Dictyostelium discoideum)
htb1 [nucleoplasm]
(Schizosaccharomyces pombe)
Homologues of Ub-HIST1H2BB [nucleoplasm]
(Dictyostelium discoideum)
Homologues of Ub-HIST1H2BB [nucleoplasm]
(Gallus gallus)
Homologues of Ub-HIST1H2BB [nucleoplasm]
(Saccharomyces cerevisiae)
h2bc11 [nucleoplasm]
(Xenopus tropicalis)
H2B-V [nucleoplasm]
(Gallus gallus)
Ub-HIST1H2BO [nucleoplasm]
(Bos taurus)
H2Bv3 [nucleoplasm]
(Dictyostelium discoideum)
H2B-VII [nucleoplasm]
(Gallus gallus)
H2BC3 [nucleoplasm]
(Canis familiaris)
hist2h2l [nucleoplasm]
(Danio rerio)
HTB1 [nucleoplasm]
(Saccharomyces cerevisiae)
HTB2 [nucleoplasm]
(Saccharomyces cerevisiae)
Modified Residues
Name
ubiquitinylated lysine (monoUb [nucleoplasm]) at 120
Coordinate
120
Modification
monoUb [nucleoplasm]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
NP_003518.2
OpenTargets
ENSG00000274641
GeneCards
P23527
HPA
ENSG00000274641-H2BC17
Ensembl
ENST00000616182
,
ENSP00000477527
,
ENSG00000274641
PRO
P23527
Pharos - Targets
P23527
PDB
7WLP
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q01831 XPC
5
XPC [nucleoplasm]
(R-HSA-67441)
Ub-XPC [nucleoplasm]
(R-HSA-6782944)
Ub,SUMO-XPC [nucleoplasm]
(R-HSA-6790460)
Ub,SUMO,K63polyUb-XPC [nucleoplasm]
(R-HSA-6790522)
monoSUMO1-K655-XPC [nucleoplasm]
(R-HSA-4570458)
0.527
3
UniProt:P16104 H2AFX
7
Me2sR4-H2AFX [nucleoplasm]
(R-HSA-5218317)
H2AFX [nucleoplasm]
(R-HSA-56151)
p-Y143-H2AFX [nucleoplasm]
(R-HSA-5683942)
p-S140,Y143-H2AFX [nucleoplasm]
(R-HSA-5683953)
p-S140-H2AFX [nucleoplasm]
(R-HSA-75170)
K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm]
(R-HSA-5682847)
H2AFX [extracellular region]
(R-HSA-977583)
0.527
3
UniProt:Q8NAV1 PRPF38A
1
PRPF38A [nucleoplasm]
(R-HSA-8867897)
0.508
2
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