Reactome | DOK2 [cytosol]

DOK2 [cytosol]

Stable Identifier

R-HSA-204823

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Docking protein 2, Dok-2

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O60496 DOK2

Gene Names

DOK2

Chain

chain:1-412

Reference Genes

BioGPS Gene:9046 DOK2

COSMIC (genes):DOK2 DOK2

CTD Gene:9046 DOK2

dbSNP Gene:9046 DOK2

ENSEMBL:ENSG00000147443 DOK2

ENSEMBL_homo_sapiens_GENE:ENSG00000147443.13 DOK2

HGNC:2991 DOK2

KEGG Gene (Homo sapiens):9046 DOK2

Monarch:9046 DOK2

NCBI Gene:9046 DOK2

OMIM:604997 DOK2

UCSC:O60496 DOK2

Reference Transcript

RefSeq:NM_003974.3 DOK2

Other Identifiers

11755717_a_at

17075271

214054_PM_at

214054_at

3127211

3127212

3127213

3127214

3127215

3127217

3127218

3127221

3127222

31514_at

63259_s_at

64739_at

8149638

9046

A_23_P134851

GE54265

GO:0005068

GO:0005515

GO:0005737

GO:0005829

GO:0007165

GO:0007166

GO:0007169

GO:0007265

GO:0023052

GO:0043410

GO:0060090

HMNXSV003042947

Hs.71215.0.S2_3p_at

ILMN_1791211

ILMN_1805903

PH_hs_0004133

TC08001031.hg

Participates

as a member of

DOK1,DOK2,DOK4,DOK5,DOK6 [cytosol] (Homo sapiens)

as a component of

Tie2 and Dok-2 complex [plasma membrane] (Homo sapiens)

as an input of

Interaction of Tie2 and Dok-2 (Homo sapiens)

Inferred To

DOK2 [cytosol] (Bos taurus)

DOK2 [cytosol] (Canis familiaris)

DOK2 [cytosol] (Gallus gallus)

DOK2 [cytosol] (Sus scrofa)

dok2 [cytosol] (Xenopus tropicalis)

rog-1 [cytosol] (Caenorhabditis elegans)

Dok2 [cytosol] (Mus musculus)

Dok2 [cytosol] (Rattus norvegicus)

Dok [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_003965.2

OpenTargets

ENSG00000147443

HPA

ENSG00000147443-DOK2

GeneCards

O60496

Ensembl

ENSP00000276420, ENST00000276420, ENSG00000147443

PRO

O60496

Pharos - Targets

O60496

PDB

2D9W, 2DLW

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42681 TXK	3	TXK [cytosol] (R-HSA-3448733) p-Y91,Y420-TXK [cytosol] (R-HSA-3448740) p-Y420-TXK [cytosol] (R-HSA-3448734)	0.556	3
UniProt:P07947 YES1	2	MyrG-p-Y426-YES1 [plasma membrane] (R-HSA-1810411) YES1 [cytosol] (R-HSA-373640)	0.556	3
UniProt:Q96EK5 KBP			0.553	2
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.527	2
UniProt:Q53GL0 PKHO1			0.527	2
UniProt:Q9H8M7 MINY3			0.527	2
UniProt:Q9H6F2 TM38A			0.527	2
UniProt:Q9NS86 LANC2			0.527	2
UniProt:Q9NUX5 POT1	1	POT1 [nucleoplasm] (R-HSA-174890)	0.508	2
UniProt:P40763-2 STAT3			0.488	2
UniProt:Q7L591-3 DOK3			0.488	2
UniProt:Q9UKG1 APPL1	1	APPL1 [endosome membrane] (R-HSA-373630)	0.488	2
UniProt:P46108-2 CRK			0.488	2
UniProt:P46109 CRKL	2	CRKL [cytosol] (R-HSA-354384) p-CRKL [cytosol] (R-HSA-9024730)	0.488	2
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.488	2
UniProt:P06239 LCK	4	p-Y394-LCK [plasma membrane] (R-HSA-8857940) p-Y505-LCK [plasma membrane] (R-HSA-202159) p-Y394-LCK [cytosol] (R-HSA-202308) LCK [cytosol] (R-HSA-167609)	0.488	2

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