Reactome | p-S13,Y18-FUNDC1 [mitochondrial outer membrane]

p-S13,Y18-FUNDC1 [mitochondrial outer membrane]

Stable Identifier

R-HSA-8934915

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial outer membrane

Synonyms

FUN14 domain-containing protein 1, FUND1_HUMAN

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External Reference Information

External Reference

UniProt:Q8IVP5 FUNDC1

Gene Names

FUNDC1

Chain

chain:1-155

Reference Genes

BioGPS Gene:139341 FUNDC1

COSMIC (genes):FUNDC1 FUNDC1

CTD Gene:139341 FUNDC1

dbSNP Gene:139341 FUNDC1

ENSEMBL:ENSG00000069509 FUNDC1

ENSEMBL_homo_sapiens_GENE:ENSG00000069509.6 FUNDC1

HGNC:28746 FUNDC1

KEGG Gene (Homo sapiens):139341 FUNDC1

Monarch:139341 FUNDC1

NCBI Gene:139341 FUNDC1

OMIM:300871 FUNDC1

UCSC:Q8IVP5 FUNDC1

Reference Transcript

RefSeq:NM_173794.3 FUNDC1

Other Identifiers

11731671_at

139341

17110342

235346_PM_at

235346_at

3395509

4006422

4006423

4006424

4006425

4006426

46047_at

8172244

A_23_P375549

GE568189

GO:0000422

GO:0001666

GO:0005515

GO:0005739

GO:0005741

GO:0006914

GO:0007005

GO:0016020

GO:0043226

HMNXSV003033143

Hs.7549.0.A1_3p_at

ILMN_1728540

PH_hs_0000781

TC0X000981.hg

Participates

as an output of

p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 (Homo sapiens)

Other forms of this molecule

p-S17-FUNDC1 [mitochondrial outer membrane]

FUNDC1 [mitochondrial outer membrane]

p-S13-FUNDC1 [mitochondrial outer membrane]

Inferred To

phospho-fndc-1 [mitochondrial outer membrane] (Caenorhabditis elegans)

phospho-Fundc1 [mitochondrial outer membrane] (Drosophila melanogaster)

phospho-Fundc1 [mitochondrial outer membrane] (Mus musculus)

phospho-Fundc1 [mitochondrial outer membrane] (Rattus norvegicus)

phospho-p-S13,Y18-FUNDC1 [mitochondrial outer membrane] (Dictyostelium discoideum)

phospho-p-S13,Y18-FUNDC1 [mitochondrial outer membrane] (Schizosaccharomyces pombe)

phospho-FUNDC1 [mitochondrial outer membrane] (Bos taurus)

phospho-FUNDC1 [mitochondrial outer membrane] (Canis familiaris)

phospho-FUNDC1 [mitochondrial outer membrane] (Gallus gallus)

phospho-FUNDC1 [mitochondrial outer membrane] (Sus scrofa)

phospho-FUN14 [mitochondrial outer membrane] (Saccharomyces cerevisiae)

phospho-fundc1 [mitochondrial outer membrane] (Danio rerio)

phospho-fundc1 [mitochondrial outer membrane] (Xenopus tropicalis)

Modified Residues

Name

O-phospho-L-serine at 13

Coordinate

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O4'-phospho-L-tyrosine at 18

Coordinate

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_776155.1

OpenTargets

ENSG00000069509

GeneCards

Q8IVP5

HPA

ENSG00000069509-FUNDC1

Ensembl

ENSP00000367284, ENSG00000069509, ENST00000378045

PRO

Q8IVP5

Pharos - Targets

Q8IVP5

PDB

2N9X, 5GMV

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9GZQ8 MAP1LC3B	3	MAP1LC3B [autophagosome membrane] (R-HSA-5683641) MAP1LC3B(2-121) [cytosol] (R-HSA-5682674) MAP1LC3B [cytosol] (R-HSA-5205651)	0.779	8
UniProt:Q9H492 MAP1LC3A	3	MAP1LC3A [autophagosome membrane] (R-HSA-5683640) MAP1LC3A(1-121) [cytosol] (R-HSA-5682681) MAP1LC3A [cytosol] (R-HSA-5205676)	0.666	4
UniProt:P60520 GABARAPL2	3	GABARAPL2 [autophagosome membrane] (R-HSA-5683633) GABARAPL2(1-117) [cytosol] (R-HSA-5682641) GABARAPL2 [cytosol] (R-HSA-5671758)	0.666	4
UniProt:Q08426 EHHADH	2	EHHADH [peroxisomal matrix] (R-HSA-400155) EHHADH [cytosol] (R-HSA-9033147)	0.666	4
UniProt:P07947 YES1	2	MyrG-p-Y426-YES1 [plasma membrane] (R-HSA-1810411) YES1 [cytosol] (R-HSA-373640)	0.666	4
UniProt:Q9Y371 SHLB1			0.556	3
UniProt:Q96E29 MTERF3	4	Ub-MTERFD1 [mitochondrial outer membrane] (R-HSA-9843333) K48polyUb-MTERFD1 [mitochondrial outer membrane] (R-HSA-5205630) K63polyUb-MTERFD1 [mitochondrial outer membrane] (R-HSA-9834044) p-S65-Ub:MTERFD1 [mitochondrial outer membrane] (R-HSA-9843337)	0.556	3
UniProt:Q96AG3 S2546			0.556	3
UniProt:P49411 TUFM	2	TUFM [mitochondrial matrix] (R-HSA-5389846) TUFM [mitochondrial outer membrane] (R-HSA-9754777)	0.556	3
UniProt:A0A384ME17 A0A384ME17			0.556	3
UniProt:P56545 CTBP2	1	CTBP2 [nucleoplasm] (R-HSA-5333990)	0.556	3
UniProt:Q9HC62 SENP2	1	SENP2 [nucleoplasm] (R-HSA-2984298)	0.556	3
UniProt:Q13596 SNX1			0.556	3
UniProt:Q9BWH2 FUND2			0.527	3
UniProt:Q9H0R8 GABARAPL1	3	GABARAPL1 [autophagosome membrane] (R-HSA-5683637) GABARAPL1(1-117) [cytosol] (R-HSA-5682659) GABARAPL1 [cytosol] (R-HSA-5671757)	0.488	2

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