Reactome | YES1 [cytosol]

YES1 [cytosol]

Stable Identifier

R-XTR-373640

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

cytosol

Synonyms

Q640S9

Locations in the PathwayBrowser

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Developmental Biology (Xenopus tropicalis)

- Nervous system development (Xenopus tropicalis)
  - Axon guidance (Xenopus tropicalis)
    - EPH-Ephrin signaling (Xenopus tropicalis)
      - EPH-ephrin mediated repulsion of cells (Xenopus tropicalis)
        
        EPHA binds TIAM1 (Xenopus tropicalis)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Xenopus tropicalis)
        
        SRC,FYN,YES,LYN [cytosol] (Xenopus tropicalis)
        
        YES1 [cytosol] (Xenopus tropicalis)
        
        EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Xenopus tropicalis)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Xenopus tropicalis)
        
        SRC,FYN,YES,LYN [cytosol] (Xenopus tropicalis)
        
        YES1 [cytosol] (Xenopus tropicalis)
        
        SFKs phosphorylate VAV2,3 (Xenopus tropicalis)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Xenopus tropicalis)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Xenopus tropicalis)
        
        SRC,FYN,YES,LYN [cytosol] (Xenopus tropicalis)
        
        YES1 [cytosol] (Xenopus tropicalis)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Xenopus tropicalis)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Xenopus tropicalis)
        
        SRC,FYN,YES,LYN [cytosol] (Xenopus tropicalis)
        
        YES1 [cytosol] (Xenopus tropicalis)
        
        SRC,FYN,YES,LYN [cytosol] (Xenopus tropicalis)
        
        YES1 [cytosol] (Xenopus tropicalis)
        
        p-EPHs bind VAV2,3 (Xenopus tropicalis)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Xenopus tropicalis)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Xenopus tropicalis)
        
        SRC,FYN,YES,LYN [cytosol] (Xenopus tropicalis)
        
        YES1 [cytosol] (Xenopus tropicalis)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Xenopus tropicalis)
        
        SRC,FYN,YES,LYN [cytosol] (Xenopus tropicalis)
        
        YES1 [cytosol] (Xenopus tropicalis)
      - EPHA-mediated growth cone collapse (Xenopus tropicalis)
        
        NGEF exchanges GTP for GDP on RHOA (Xenopus tropicalis)
        
        EFNAs:p-EPHAs:SFKs:p-Y179-NGEF [plasma membrane] (Xenopus tropicalis)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Xenopus tropicalis)
        
        SRC,FYN,YES,LYN [cytosol] (Xenopus tropicalis)
        
        YES1 [cytosol] (Xenopus tropicalis)
      - EPHB-mediated forward signaling (Xenopus tropicalis)
        
        EPHB phosphorylates TIAM1 (Xenopus tropicalis)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1 [plasma membrane] (Xenopus tropicalis)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Xenopus tropicalis)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Xenopus tropicalis)
        
        SRC,FYN,YES,LYN [cytosol] (Xenopus tropicalis)
        
        YES1 [cytosol] (Xenopus tropicalis)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:p-Y829-TIAM1 [plasma membrane] (Xenopus tropicalis)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Xenopus tropicalis)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Xenopus tropicalis)
        
        SRC,FYN,YES,LYN [cytosol] (Xenopus tropicalis)
        
        YES1 [cytosol] (Xenopus tropicalis)
        
        EPHB:NMDAR binds TIAM1 (Xenopus tropicalis)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Xenopus tropicalis)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Xenopus tropicalis)
        
        SRC,FYN,YES,LYN [cytosol] (Xenopus tropicalis)
        
        YES1 [cytosol] (Xenopus tropicalis)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1 [plasma membrane] (Xenopus tropicalis)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Xenopus tropicalis)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Xenopus tropicalis)
        
        SRC,FYN,YES,LYN [cytosol] (Xenopus tropicalis)
        
        YES1 [cytosol] (Xenopus tropicalis)

Immune System (Xenopus tropicalis)

- Adaptive Immune System (Xenopus tropicalis)
  - Regulation of T cell activation by CD28 family (Xenopus tropicalis)
    - Co-inhibition by CTLA4 (Xenopus tropicalis)
      - Phosphorylation of CTLA-4 (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        YES1 [cytosol] (Xenopus tropicalis)
        
        p-Y201,Y218-CTLA-4 dimer:SFKs [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        YES1 [cytosol] (Xenopus tropicalis)
      - SHP2 phosphatase binds CTLA-4 (Xenopus tropicalis)
        
        p-Y201,Y218-CTLA-4 dimer:SFKs [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        YES1 [cytosol] (Xenopus tropicalis)
        
        pCTLA-4:Src kinases:SHP2 [plasma membrane] (Xenopus tropicalis)
        
        p-Y201,Y218-CTLA-4 dimer:SFKs [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        YES1 [cytosol] (Xenopus tropicalis)
    - Co-stimulation by CD28 (Xenopus tropicalis)
      - Phosphorylation of CD28 (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        YES1 [cytosol] (Xenopus tropicalis)
- Cytokine Signaling in Immune system (Xenopus tropicalis)
  - Signaling by Interleukins (Xenopus tropicalis)
    - Interleukin-3, Interleukin-5 and GM-CSF signaling (Xenopus tropicalis)
      - Regulation of signaling by CBL (Xenopus tropicalis)
        
        CBL ubiquitinates PI3K (Xenopus tropicalis)
        
        FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] (Xenopus tropicalis)
        
        FYN-like kinases [cytosol] (Xenopus tropicalis)
        
        YES1 [cytosol] (Xenopus tropicalis)
        
        FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Xenopus tropicalis)
        
        FYN-like kinases [cytosol] (Xenopus tropicalis)
        
        YES1 [cytosol] (Xenopus tropicalis)

Signal Transduction (Xenopus tropicalis)

- Signaling by Receptor Tyrosine Kinases (Xenopus tropicalis)
  - Signaling by SCF-KIT (Xenopus tropicalis)
    - Dimerization of STATs (Xenopus tropicalis)
      - p-JAK2:SFKs:p-KIT complex:p-STAT dimers [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        YES1 [cytosol] (Xenopus tropicalis)
      - p-JAK2:SFKs:p-KIT complex:p-STATs [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        YES1 [cytosol] (Xenopus tropicalis)
    - Disassociation and translocation of STATs to the nucleus (Xenopus tropicalis)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        YES1 [cytosol] (Xenopus tropicalis)
      - p-JAK2:SFKs:p-KIT complex:p-STAT dimers [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        YES1 [cytosol] (Xenopus tropicalis)
    - GRB2 is indirectly recruited to p-KIT through SHP2 (Xenopus tropicalis)
      - GRB2:p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        YES1 [cytosol] (Xenopus tropicalis)
      - p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        YES1 [cytosol] (Xenopus tropicalis)
    - Indirect recruitment of GAB2 to p-KIT (Xenopus tropicalis)
      - GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        YES1 [cytosol] (Xenopus tropicalis)
      - GRB2:p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        YES1 [cytosol] (Xenopus tropicalis)
    - Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Xenopus tropicalis)
      - PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        YES1 [cytosol] (Xenopus tropicalis)
      - p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        YES1 [cytosol] (Xenopus tropicalis)
    - JAK2 binds to p-KIT (Xenopus tropicalis)
      - JAK2:SFKS:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        YES1 [cytosol] (Xenopus tropicalis)
      - SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        YES1 [cytosol] (Xenopus tropicalis)
    - Phosphorylation and activation of VAV1 (Xenopus tropicalis)
      - SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        YES1 [cytosol] (Xenopus tropicalis)
      - Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        YES1 [cytosol] (Xenopus tropicalis)
    - Phosphorylation of GAB2 by SFKs (Xenopus tropicalis)
      - GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        YES1 [cytosol] (Xenopus tropicalis)
      - Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        YES1 [cytosol] (Xenopus tropicalis)
      - p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        YES1 [cytosol] (Xenopus tropicalis)
    - Phosphorylation of JAK2 (Xenopus tropicalis)
      - JAK2:SFKS:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        YES1 [cytosol] (Xenopus tropicalis)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        YES1 [cytosol] (Xenopus tropicalis)
    - Phosphorylation of SHP2 by SFKs (Xenopus tropicalis)
      - SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        YES1 [cytosol] (Xenopus tropicalis)
      - Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        YES1 [cytosol] (Xenopus tropicalis)
      - p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        YES1 [cytosol] (Xenopus tropicalis)
    - Phosphorylation of STATs (Xenopus tropicalis)
      - p-JAK2:SFKs:p-KIT complex:STATs [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        YES1 [cytosol] (Xenopus tropicalis)
      - p-JAK2:SFKs:p-KIT complex:p-STATs [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        YES1 [cytosol] (Xenopus tropicalis)
    - Phosphorylation of p-KIT on Y900 by Src kinases (Xenopus tropicalis)
      - SFKs:p-8Y-KIT:sSCF dimer:p-8Y-KIT [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        YES1 [cytosol] (Xenopus tropicalis)
      - SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        YES1 [cytosol] (Xenopus tropicalis)
      - Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        YES1 [cytosol] (Xenopus tropicalis)
    - Recruitment of STATs (Xenopus tropicalis)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        YES1 [cytosol] (Xenopus tropicalis)
      - p-JAK2:SFKs:p-KIT complex:STATs [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        YES1 [cytosol] (Xenopus tropicalis)
    - Regulation of KIT signaling (Xenopus tropicalis)
      - Interaction of APS and p-KIT (Xenopus tropicalis)
        
        APS dimer:p-c-Kit:SFKs complex [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        YES1 [cytosol] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        YES1 [cytosol] (Xenopus tropicalis)
      - Phosphorylation of APS (Xenopus tropicalis)
        
        APS dimer:p-c-Kit:SFKs complex [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        YES1 [cytosol] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        YES1 [cytosol] (Xenopus tropicalis)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        YES1 [cytosol] (Xenopus tropicalis)
    - SHP2 interacts with p-KIT (Xenopus tropicalis)
      - SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        YES1 [cytosol] (Xenopus tropicalis)
      - SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        YES1 [cytosol] (Xenopus tropicalis)
    - Synthesis of PIP3 from PIP2 by PI3K (Xenopus tropicalis)
      - PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        p-SHP2:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        SFKs:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Xenopus tropicalis)
        
        YES1 [cytosol] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:Q640S9

Reference Genes

BioGPS Gene:493548

ENSEMBL:ENSXETG00000019176

KEGG:xtr:493548

Monarch:493548

NCBI Gene:493548

UCSC:Q640S9

Reference Transcript

Other Identifiers

493548

GO:0000166

GO:0003824

GO:0004672

GO:0004713

GO:0004715

GO:0005102

GO:0005524

GO:0005886

GO:0007169

GO:0016020

GO:0016301

GO:0016740

GO:0030154

GO:0140096

Participates

as a candidate of

FYN-like kinases [cytosol] (Xenopus tropicalis)

as a member of

Inferred From

YES1 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_012820031.1, NP_001008186.1

ENSEMBL

ENSXETG00000019176, ENSXETT00000041569, ENSXETP00000041569

Xenbase

XB-GENE-495082

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