Reactome | YES1 [cytosol]

YES1 [cytosol]

Stable Identifier

R-RNO-373640

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

F1LM93

Locations in the PathwayBrowser

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Developmental Biology (Rattus norvegicus)

- Nervous system development (Rattus norvegicus)
  - Axon guidance (Rattus norvegicus)
    - EPH-Ephrin signaling (Rattus norvegicus)
      - EPH-ephrin mediated repulsion of cells (Rattus norvegicus)
        
        EPHA binds TIAM1 (Rattus norvegicus)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Rattus norvegicus)
        
        SRC,FYN,YES,LYN [cytosol] (Rattus norvegicus)
        
        YES1 [cytosol] (Rattus norvegicus)
        
        EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Rattus norvegicus)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Rattus norvegicus)
        
        SRC,FYN,YES,LYN [cytosol] (Rattus norvegicus)
        
        YES1 [cytosol] (Rattus norvegicus)
        
        SFKs phosphorylate VAV2,3 (Rattus norvegicus)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Rattus norvegicus)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Rattus norvegicus)
        
        SRC,FYN,YES,LYN [cytosol] (Rattus norvegicus)
        
        YES1 [cytosol] (Rattus norvegicus)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Rattus norvegicus)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Rattus norvegicus)
        
        SRC,FYN,YES,LYN [cytosol] (Rattus norvegicus)
        
        YES1 [cytosol] (Rattus norvegicus)
        
        SRC,FYN,YES,LYN [cytosol] (Rattus norvegicus)
        
        YES1 [cytosol] (Rattus norvegicus)
        
        TIAM1 exchanges GTP for GDP on RAC1, activating it (Rattus norvegicus)
        
        EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Rattus norvegicus)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Rattus norvegicus)
        
        SRC,FYN,YES,LYN [cytosol] (Rattus norvegicus)
        
        YES1 [cytosol] (Rattus norvegicus)
        
        VAV exchanges GTP for GDP on RAC1, activating it (Rattus norvegicus)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Rattus norvegicus)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Rattus norvegicus)
        
        SRC,FYN,YES,LYN [cytosol] (Rattus norvegicus)
        
        YES1 [cytosol] (Rattus norvegicus)
        
        p-EPHs bind VAV2,3 (Rattus norvegicus)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Rattus norvegicus)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Rattus norvegicus)
        
        SRC,FYN,YES,LYN [cytosol] (Rattus norvegicus)
        
        YES1 [cytosol] (Rattus norvegicus)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Rattus norvegicus)
        
        SRC,FYN,YES,LYN [cytosol] (Rattus norvegicus)
        
        YES1 [cytosol] (Rattus norvegicus)
      - EPHA-mediated growth cone collapse (Rattus norvegicus)
        
        NGEF exchanges GTP for GDP on RHOA (Rattus norvegicus)
        
        EFNAs:p-EPHAs:SFKs:p-Y179-NGEF [plasma membrane] (Rattus norvegicus)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Rattus norvegicus)
        
        SRC,FYN,YES,LYN [cytosol] (Rattus norvegicus)
        
        YES1 [cytosol] (Rattus norvegicus)
      - EPHB-mediated forward signaling (Rattus norvegicus)
        
        EPHB phosphorylates TIAM1 (Rattus norvegicus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1 [plasma membrane] (Rattus norvegicus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Rattus norvegicus)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Rattus norvegicus)
        
        SRC,FYN,YES,LYN [cytosol] (Rattus norvegicus)
        
        YES1 [cytosol] (Rattus norvegicus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:p-Y829-TIAM1 [plasma membrane] (Rattus norvegicus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Rattus norvegicus)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Rattus norvegicus)
        
        SRC,FYN,YES,LYN [cytosol] (Rattus norvegicus)
        
        YES1 [cytosol] (Rattus norvegicus)
        
        EPHB:NMDAR binds TIAM1 (Rattus norvegicus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Rattus norvegicus)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Rattus norvegicus)
        
        SRC,FYN,YES,LYN [cytosol] (Rattus norvegicus)
        
        YES1 [cytosol] (Rattus norvegicus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1 [plasma membrane] (Rattus norvegicus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Rattus norvegicus)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Rattus norvegicus)
        
        SRC,FYN,YES,LYN [cytosol] (Rattus norvegicus)
        
        YES1 [cytosol] (Rattus norvegicus)
        
        p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Rattus norvegicus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:p-Y829-TIAM1 [plasma membrane] (Rattus norvegicus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Rattus norvegicus)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Rattus norvegicus)
        
        SRC,FYN,YES,LYN [cytosol] (Rattus norvegicus)
        
        YES1 [cytosol] (Rattus norvegicus)

Signal Transduction (Rattus norvegicus)

- Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
  - Signaling by SCF-KIT (Rattus norvegicus)
    - Dimerization of STATs (Rattus norvegicus)
      - p-JAK2:SFKs:p-KIT complex:p-STAT dimers [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        YES1 [cytosol] (Rattus norvegicus)
      - p-JAK2:SFKs:p-KIT complex:p-STATs [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        YES1 [cytosol] (Rattus norvegicus)
    - Disassociation and translocation of STATs to the nucleus (Rattus norvegicus)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        YES1 [cytosol] (Rattus norvegicus)
      - p-JAK2:SFKs:p-KIT complex:p-STAT dimers [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        YES1 [cytosol] (Rattus norvegicus)
    - GRB2 is indirectly recruited to p-KIT through SHP2 (Rattus norvegicus)
      - GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        YES1 [cytosol] (Rattus norvegicus)
      - p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        YES1 [cytosol] (Rattus norvegicus)
    - Indirect recruitment of GAB2 to p-KIT (Rattus norvegicus)
      - GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        YES1 [cytosol] (Rattus norvegicus)
      - GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        YES1 [cytosol] (Rattus norvegicus)
    - Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Rattus norvegicus)
      - PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        YES1 [cytosol] (Rattus norvegicus)
      - p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        YES1 [cytosol] (Rattus norvegicus)
    - JAK2 binds to p-KIT (Rattus norvegicus)
      - JAK2:SFKS:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        YES1 [cytosol] (Rattus norvegicus)
      - SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        YES1 [cytosol] (Rattus norvegicus)
    - Phosphorylation and activation of VAV1 (Rattus norvegicus)
      - SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        YES1 [cytosol] (Rattus norvegicus)
      - Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        YES1 [cytosol] (Rattus norvegicus)
    - Phosphorylation of GAB2 by SFKs (Rattus norvegicus)
      - GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        YES1 [cytosol] (Rattus norvegicus)
      - Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        YES1 [cytosol] (Rattus norvegicus)
      - p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        YES1 [cytosol] (Rattus norvegicus)
    - Phosphorylation of JAK2 (Rattus norvegicus)
      - JAK2:SFKS:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        YES1 [cytosol] (Rattus norvegicus)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        YES1 [cytosol] (Rattus norvegicus)
    - Phosphorylation of SHP2 by SFKs (Rattus norvegicus)
      - SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        YES1 [cytosol] (Rattus norvegicus)
      - Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        YES1 [cytosol] (Rattus norvegicus)
      - p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        YES1 [cytosol] (Rattus norvegicus)
    - Phosphorylation of STATs (Rattus norvegicus)
      - p-JAK2:SFKs:p-KIT complex:STATs [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        YES1 [cytosol] (Rattus norvegicus)
      - p-JAK2:SFKs:p-KIT complex:p-STATs [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        YES1 [cytosol] (Rattus norvegicus)
    - Phosphorylation of p-KIT on Y900 by Src kinases (Rattus norvegicus)
      - SFKs:p-8Y-KIT:sSCF dimer:p-8Y-KIT [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        YES1 [cytosol] (Rattus norvegicus)
      - SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        YES1 [cytosol] (Rattus norvegicus)
      - Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        YES1 [cytosol] (Rattus norvegicus)
    - Recruitment of STATs (Rattus norvegicus)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        YES1 [cytosol] (Rattus norvegicus)
      - p-JAK2:SFKs:p-KIT complex:STATs [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        YES1 [cytosol] (Rattus norvegicus)
    - Regulation of KIT signaling (Rattus norvegicus)
      - Interaction of APS and p-KIT (Rattus norvegicus)
        
        APS dimer:p-c-Kit:SFKs complex [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        YES1 [cytosol] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        YES1 [cytosol] (Rattus norvegicus)
      - Phosphorylation of APS (Rattus norvegicus)
        
        APS dimer:p-c-Kit:SFKs complex [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        YES1 [cytosol] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        YES1 [cytosol] (Rattus norvegicus)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        YES1 [cytosol] (Rattus norvegicus)
      - Recruitment of CBL to KIT (Rattus norvegicus)
        
        CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane] (Rattus norvegicus)
        
        Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Rattus norvegicus)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        YES1 [cytosol] (Rattus norvegicus)
        
        Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Rattus norvegicus)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        YES1 [cytosol] (Rattus norvegicus)
    - SHP2 interacts with p-KIT (Rattus norvegicus)
      - SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        YES1 [cytosol] (Rattus norvegicus)
      - SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        YES1 [cytosol] (Rattus norvegicus)
    - Synthesis of PIP3 from PIP2 by PI3K (Rattus norvegicus)
      - PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        YES1 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:F1LM93 Yes1

Gene Names

Yes1

Chain

initiator methionine:, chain:2-541

Reference Genes

UCSC:F1LM93 Yes1

Participates

as a candidate of

FYN-like kinases [cytosol] (Rattus norvegicus)

as a member of

Other forms of this molecule

MyrG-p-Y424-Yes1 [plasma membrane]

phospho-MyrG-p-Y426-YES1 [plasma membrane]

Inferred From

YES1 [cytosol] (Homo sapiens)

Cross References

IntEnz

2.7.10.2

PRO

F1LM93

RGD

3977

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