Reactome | YES1 [cytosol]

YES1 [cytosol]

Stable Identifier

R-SSC-373640

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

cytosol

Synonyms

A0A5G2QU81

Locations in the PathwayBrowser

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Developmental Biology (Sus scrofa)

- Nervous system development (Sus scrofa)
  - Axon guidance (Sus scrofa)
    - EPH-Ephrin signaling (Sus scrofa)
      - EPH-ephrin mediated repulsion of cells (Sus scrofa)
        
        EPHA binds TIAM1 (Sus scrofa)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Sus scrofa)
        
        SRC,FYN,YES,LYN [cytosol] (Sus scrofa)
        
        YES1 [cytosol] (Sus scrofa)
        
        EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Sus scrofa)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Sus scrofa)
        
        SRC,FYN,YES,LYN [cytosol] (Sus scrofa)
        
        YES1 [cytosol] (Sus scrofa)
        
        SFKs phosphorylate VAV2,3 (Sus scrofa)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Sus scrofa)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Sus scrofa)
        
        SRC,FYN,YES,LYN [cytosol] (Sus scrofa)
        
        YES1 [cytosol] (Sus scrofa)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Sus scrofa)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Sus scrofa)
        
        SRC,FYN,YES,LYN [cytosol] (Sus scrofa)
        
        YES1 [cytosol] (Sus scrofa)
        
        SRC,FYN,YES,LYN [cytosol] (Sus scrofa)
        
        YES1 [cytosol] (Sus scrofa)
        
        TIAM1 exchanges GTP for GDP on RAC1, activating it (Sus scrofa)
        
        EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Sus scrofa)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Sus scrofa)
        
        SRC,FYN,YES,LYN [cytosol] (Sus scrofa)
        
        YES1 [cytosol] (Sus scrofa)
        
        VAV exchanges GTP for GDP on RAC1, activating it (Sus scrofa)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Sus scrofa)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Sus scrofa)
        
        SRC,FYN,YES,LYN [cytosol] (Sus scrofa)
        
        YES1 [cytosol] (Sus scrofa)
        
        p-EPHs bind VAV2,3 (Sus scrofa)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Sus scrofa)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Sus scrofa)
        
        SRC,FYN,YES,LYN [cytosol] (Sus scrofa)
        
        YES1 [cytosol] (Sus scrofa)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Sus scrofa)
        
        SRC,FYN,YES,LYN [cytosol] (Sus scrofa)
        
        YES1 [cytosol] (Sus scrofa)
      - EPHA-mediated growth cone collapse (Sus scrofa)
        
        NGEF exchanges GTP for GDP on RHOA (Sus scrofa)
        
        EFNAs:p-EPHAs:SFKs:p-Y179-NGEF [plasma membrane] (Sus scrofa)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Sus scrofa)
        
        SRC,FYN,YES,LYN [cytosol] (Sus scrofa)
        
        YES1 [cytosol] (Sus scrofa)
      - EPHB-mediated forward signaling (Sus scrofa)
        
        EPHB phosphorylates TIAM1 (Sus scrofa)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1 [plasma membrane] (Sus scrofa)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Sus scrofa)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Sus scrofa)
        
        SRC,FYN,YES,LYN [cytosol] (Sus scrofa)
        
        YES1 [cytosol] (Sus scrofa)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:p-Y829-TIAM1 [plasma membrane] (Sus scrofa)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Sus scrofa)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Sus scrofa)
        
        SRC,FYN,YES,LYN [cytosol] (Sus scrofa)
        
        YES1 [cytosol] (Sus scrofa)
        
        EPHB:NMDAR binds TIAM1 (Sus scrofa)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Sus scrofa)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Sus scrofa)
        
        SRC,FYN,YES,LYN [cytosol] (Sus scrofa)
        
        YES1 [cytosol] (Sus scrofa)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1 [plasma membrane] (Sus scrofa)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Sus scrofa)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Sus scrofa)
        
        SRC,FYN,YES,LYN [cytosol] (Sus scrofa)
        
        YES1 [cytosol] (Sus scrofa)
        
        p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Sus scrofa)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:p-Y829-TIAM1 [plasma membrane] (Sus scrofa)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Sus scrofa)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Sus scrofa)
        
        SRC,FYN,YES,LYN [cytosol] (Sus scrofa)
        
        YES1 [cytosol] (Sus scrofa)

Signal Transduction (Sus scrofa)

- Signaling by Receptor Tyrosine Kinases (Sus scrofa)
  - Signaling by SCF-KIT (Sus scrofa)
    - Dimerization of STATs (Sus scrofa)
      - p-JAK2:SFKs:p-KIT complex:p-STAT dimers [plasma membrane] (Sus scrofa)
        
        SFKs:p-KIT complex [plasma membrane] (Sus scrofa)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Sus scrofa)
        
        YES1 [cytosol] (Sus scrofa)
      - p-JAK2:SFKs:p-KIT complex:p-STATs [plasma membrane] (Sus scrofa)
        
        SFKs:p-KIT complex [plasma membrane] (Sus scrofa)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Sus scrofa)
        
        YES1 [cytosol] (Sus scrofa)
    - Disassociation and translocation of STATs to the nucleus (Sus scrofa)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Sus scrofa)
        
        SFKs:p-KIT complex [plasma membrane] (Sus scrofa)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Sus scrofa)
        
        YES1 [cytosol] (Sus scrofa)
      - p-JAK2:SFKs:p-KIT complex:p-STAT dimers [plasma membrane] (Sus scrofa)
        
        SFKs:p-KIT complex [plasma membrane] (Sus scrofa)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Sus scrofa)
        
        YES1 [cytosol] (Sus scrofa)
    - GRB2 is indirectly recruited to p-KIT through SHP2 (Sus scrofa)
      - GRB2:p-SHP2:p-KIT complex [plasma membrane] (Sus scrofa)
        
        p-SHP2:p-KIT complex [plasma membrane] (Sus scrofa)
        
        SFKs:p-KIT complex [plasma membrane] (Sus scrofa)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Sus scrofa)
        
        YES1 [cytosol] (Sus scrofa)
      - p-SHP2:p-KIT complex [plasma membrane] (Sus scrofa)
        
        SFKs:p-KIT complex [plasma membrane] (Sus scrofa)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Sus scrofa)
        
        YES1 [cytosol] (Sus scrofa)
    - Indirect recruitment of GAB2 to p-KIT (Sus scrofa)
      - GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Sus scrofa)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Sus scrofa)
        
        p-SHP2:p-KIT complex [plasma membrane] (Sus scrofa)
        
        SFKs:p-KIT complex [plasma membrane] (Sus scrofa)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Sus scrofa)
        
        YES1 [cytosol] (Sus scrofa)
      - GRB2:p-SHP2:p-KIT complex [plasma membrane] (Sus scrofa)
        
        p-SHP2:p-KIT complex [plasma membrane] (Sus scrofa)
        
        SFKs:p-KIT complex [plasma membrane] (Sus scrofa)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Sus scrofa)
        
        YES1 [cytosol] (Sus scrofa)
    - Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Sus scrofa)
      - PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Sus scrofa)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Sus scrofa)
        
        p-SHP2:p-KIT complex [plasma membrane] (Sus scrofa)
        
        SFKs:p-KIT complex [plasma membrane] (Sus scrofa)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Sus scrofa)
        
        YES1 [cytosol] (Sus scrofa)
      - p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Sus scrofa)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Sus scrofa)
        
        p-SHP2:p-KIT complex [plasma membrane] (Sus scrofa)
        
        SFKs:p-KIT complex [plasma membrane] (Sus scrofa)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Sus scrofa)
        
        YES1 [cytosol] (Sus scrofa)
    - JAK2 binds to p-KIT (Sus scrofa)
      - JAK2:SFKS:p-KIT complex [plasma membrane] (Sus scrofa)
        
        SFKs:p-KIT complex [plasma membrane] (Sus scrofa)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Sus scrofa)
        
        YES1 [cytosol] (Sus scrofa)
      - SFKs:p-KIT complex [plasma membrane] (Sus scrofa)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Sus scrofa)
        
        YES1 [cytosol] (Sus scrofa)
    - Phosphorylation and activation of VAV1 (Sus scrofa)
      - SFKs:p-KIT complex [plasma membrane] (Sus scrofa)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Sus scrofa)
        
        YES1 [cytosol] (Sus scrofa)
      - Src family tyrosine kinases (SFKs) [cytosol] (Sus scrofa)
        
        YES1 [cytosol] (Sus scrofa)
    - Phosphorylation of GAB2 by SFKs (Sus scrofa)
      - GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Sus scrofa)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Sus scrofa)
        
        p-SHP2:p-KIT complex [plasma membrane] (Sus scrofa)
        
        SFKs:p-KIT complex [plasma membrane] (Sus scrofa)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Sus scrofa)
        
        YES1 [cytosol] (Sus scrofa)
      - Src family tyrosine kinases (SFKs) [cytosol] (Sus scrofa)
        
        YES1 [cytosol] (Sus scrofa)
      - p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Sus scrofa)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Sus scrofa)
        
        p-SHP2:p-KIT complex [plasma membrane] (Sus scrofa)
        
        SFKs:p-KIT complex [plasma membrane] (Sus scrofa)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Sus scrofa)
        
        YES1 [cytosol] (Sus scrofa)
    - Phosphorylation of JAK2 (Sus scrofa)
      - JAK2:SFKS:p-KIT complex [plasma membrane] (Sus scrofa)
        
        SFKs:p-KIT complex [plasma membrane] (Sus scrofa)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Sus scrofa)
        
        YES1 [cytosol] (Sus scrofa)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Sus scrofa)
        
        SFKs:p-KIT complex [plasma membrane] (Sus scrofa)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Sus scrofa)
        
        YES1 [cytosol] (Sus scrofa)
    - Phosphorylation of SHP2 by SFKs (Sus scrofa)
      - SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Sus scrofa)
        
        SFKs:p-KIT complex [plasma membrane] (Sus scrofa)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Sus scrofa)
        
        YES1 [cytosol] (Sus scrofa)
      - Src family tyrosine kinases (SFKs) [cytosol] (Sus scrofa)
        
        YES1 [cytosol] (Sus scrofa)
      - p-SHP2:p-KIT complex [plasma membrane] (Sus scrofa)
        
        SFKs:p-KIT complex [plasma membrane] (Sus scrofa)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Sus scrofa)
        
        YES1 [cytosol] (Sus scrofa)
    - Phosphorylation of STATs (Sus scrofa)
      - p-JAK2:SFKs:p-KIT complex:STATs [plasma membrane] (Sus scrofa)
        
        SFKs:p-KIT complex [plasma membrane] (Sus scrofa)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Sus scrofa)
        
        YES1 [cytosol] (Sus scrofa)
      - p-JAK2:SFKs:p-KIT complex:p-STATs [plasma membrane] (Sus scrofa)
        
        SFKs:p-KIT complex [plasma membrane] (Sus scrofa)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Sus scrofa)
        
        YES1 [cytosol] (Sus scrofa)
    - Phosphorylation of p-KIT on Y900 by Src kinases (Sus scrofa)
      - SFKs:p-8Y-KIT:sSCF dimer:p-8Y-KIT [plasma membrane] (Sus scrofa)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Sus scrofa)
        
        YES1 [cytosol] (Sus scrofa)
      - SFKs:p-KIT complex [plasma membrane] (Sus scrofa)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Sus scrofa)
        
        YES1 [cytosol] (Sus scrofa)
      - Src family tyrosine kinases (SFKs) [cytosol] (Sus scrofa)
        
        YES1 [cytosol] (Sus scrofa)
    - Recruitment of STATs (Sus scrofa)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Sus scrofa)
        
        SFKs:p-KIT complex [plasma membrane] (Sus scrofa)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Sus scrofa)
        
        YES1 [cytosol] (Sus scrofa)
      - p-JAK2:SFKs:p-KIT complex:STATs [plasma membrane] (Sus scrofa)
        
        SFKs:p-KIT complex [plasma membrane] (Sus scrofa)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Sus scrofa)
        
        YES1 [cytosol] (Sus scrofa)
    - Regulation of KIT signaling (Sus scrofa)
      - Interaction of APS and p-KIT (Sus scrofa)
        
        APS dimer:p-c-Kit:SFKs complex [plasma membrane] (Sus scrofa)
        
        SFKs:p-KIT complex [plasma membrane] (Sus scrofa)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Sus scrofa)
        
        YES1 [cytosol] (Sus scrofa)
        
        SFKs:p-KIT complex [plasma membrane] (Sus scrofa)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Sus scrofa)
        
        YES1 [cytosol] (Sus scrofa)
      - Phosphorylation of APS (Sus scrofa)
        
        APS dimer:p-c-Kit:SFKs complex [plasma membrane] (Sus scrofa)
        
        SFKs:p-KIT complex [plasma membrane] (Sus scrofa)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Sus scrofa)
        
        YES1 [cytosol] (Sus scrofa)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Sus scrofa)
        
        YES1 [cytosol] (Sus scrofa)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Sus scrofa)
        
        SFKs:p-KIT complex [plasma membrane] (Sus scrofa)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Sus scrofa)
        
        YES1 [cytosol] (Sus scrofa)
      - Recruitment of CBL to KIT (Sus scrofa)
        
        CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane] (Sus scrofa)
        
        Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Sus scrofa)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Sus scrofa)
        
        SFKs:p-KIT complex [plasma membrane] (Sus scrofa)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Sus scrofa)
        
        YES1 [cytosol] (Sus scrofa)
        
        Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Sus scrofa)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Sus scrofa)
        
        SFKs:p-KIT complex [plasma membrane] (Sus scrofa)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Sus scrofa)
        
        YES1 [cytosol] (Sus scrofa)
    - SHP2 interacts with p-KIT (Sus scrofa)
      - SFKs:p-KIT complex [plasma membrane] (Sus scrofa)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Sus scrofa)
        
        YES1 [cytosol] (Sus scrofa)
      - SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Sus scrofa)
        
        SFKs:p-KIT complex [plasma membrane] (Sus scrofa)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Sus scrofa)
        
        YES1 [cytosol] (Sus scrofa)
    - Synthesis of PIP3 from PIP2 by PI3K (Sus scrofa)
      - PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Sus scrofa)
        
        PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Sus scrofa)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Sus scrofa)
        
        p-SHP2:p-KIT complex [plasma membrane] (Sus scrofa)
        
        SFKs:p-KIT complex [plasma membrane] (Sus scrofa)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Sus scrofa)
        
        YES1 [cytosol] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A5G2QU81

Reference Genes

ENSEMBL:ENSSSCG00000031942.2

UCSC:A0A5G2QU81

Other Identifiers

100627112

GO:0000166

GO:0001784

GO:0003824

GO:0004672

GO:0004713

GO:0004715

GO:0005102

GO:0005515

GO:0005524

GO:0005737

GO:0005794

GO:0005829

GO:0005886

GO:0006468

GO:0007169

GO:0012505

GO:0016020

GO:0016301

GO:0016740

GO:0019899

GO:0030154

GO:0030182

GO:0044325

GO:0048468

GO:0048856

GO:0050793

GO:0140096

Ssc.6801.1.S1_at

Ssc.7502.1.A1_at

Participates

as a candidate of

FYN-like kinases [cytosol] (Sus scrofa)

as a member of

Other forms of this molecule

phospho-MyrG-p-Y426-YES1 [plasma membrane]

Inferred From

YES1 [cytosol] (Homo sapiens)

Cross References

ENSEMBL

ENSSSCG00000031942, ENSSSCP00000061695, ENSSSCT00000074308

VGNC

95024

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