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CBLB [cytosol]
Stable Identifier
R-HSA-976009
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
E3 ubiquitin-protein ligase CBL-B, CBLB_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
CBLB [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
CBLB [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
CBLB [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
CBLB [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
CBLB [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
CBLB [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
CBLB [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
CBLB [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
CBLB [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
CBLB [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13191 CBLB
Gene Names
CBLB, RNF56, Nbla00127
Chain
chain:1-982
Reference Genes
COSMIC (genes):CBLB CBLB
dbSNP Gene:868 CBLB
ENSEMBL:ENSG00000114423 CBLB
Participates
as a candidate of
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
Inferred To
sli-1 [cytosol]
(Caenorhabditis elegans)
Cbl [cytosol]
(Drosophila melanogaster)
CBLB [cytosol]
(Bos taurus)
CBLB [cytosol]
(Canis familiaris)
CBLB [cytosol]
(Gallus gallus)
CBLB [cytosol]
(Mus musculus)
CBLB [cytosol]
(Plasmodium falciparum)
CBLB [cytosol]
(Rattus norvegicus)
CBLB [cytosol]
(Sus scrofa)
CBLB [cytosol]
(Xenopus tropicalis)
Interactors (16)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.967
30
UniProt:Q96B97 SH3KBP1
3
SH3KBP1 [plasma membrane]
(R-HSA-182955)
SH3KBP1 [cytosol]
(R-HSA-182957)
Ub-SH3KBP1 [cytosol]
(R-HSA-182926)
0.939
25
UniProt:O43639 NCK2
1
NCK2 [cytosol]
(R-HSA-204885)
0.871
9
UniProt:Q9Y5K6 CD2AP
1
CD2AP [cytosol]
(R-HSA-373620)
0.747
11
UniProt:P46108 CRK
1
CRK [cytosol]
(R-HSA-2980677)
0.709
5
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.683
4
UniProt:P46109 CRKL
2
CRKL [cytosol]
(R-HSA-354384)
p-CRKL [cytosol]
(R-HSA-9024730)
0.621
4
UniProt:Q13882 PTK6
5
PTK6 [cytosol]
(R-HSA-8848000)
p-Y342-PTK6 [cytosol]
(R-HSA-8848007)
p-Y342-PTK6 [nucleoplasm]
(R-HSA-8848937)
p-Y351-PTK6 [cytosol]
(R-HSA-8857570)
p-Y342,Y447-PTK6 [cytosol]
(R-HSA-8849103)
0.556
3
UniProt:P00441 SOD1
5
2xHC-SOD1 [cytosol]
(R-HSA-3299726)
SOD1 [cytosol]
(R-HSA-350697)
2xHC-SOD1 [mitochondrial intermembrane space]
(R-HSA-3777108)
SOD1 [mitochondrial intermembrane space]
(R-HSA-3777082)
SOD1 [extracellular region]
(R-HSA-350705)
0.556
3
UniProt:P07947 YES1
2
MyrG-p-Y426-YES1 [plasma membrane]
(R-HSA-1810411)
YES1 [cytosol]
(R-HSA-373640)
0.556
3
UniProt:Q00403 GTF2B
1
GTF2B [nucleoplasm]
(R-HSA-65888)
0.556
3
UniProt:Q01658 DR1
1
DR1 [nucleoplasm]
(R-HSA-3662280)
0.556
3
UniProt:O76003 GLRX3
1
GLRX3 [cytosol]
(R-HSA-5691202)
0.556
3
UniProt:Q9UKW4 VAV3
2
VAV3 [cytosol]
(R-HSA-430152)
p-Y173-VAV3 [cytosol]
(R-HSA-442287)
0.556
3
UniProt:Q14155 ARHGEF7
1
ARHGEF7 [cytosol]
(R-HSA-430346)
0.508
2
UniProt:Q9UKG1 APPL1
1
APPL1 [endosome membrane]
(R-HSA-373630)
0.488
2
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