Reactome | YES1 [cytosol]

YES1 [cytosol]

Stable Identifier

R-BTA-373640

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

YES1, A7MB57

Locations in the PathwayBrowser

Expand all

Developmental Biology (Bos taurus)

- Nervous system development (Bos taurus)
  - Axon guidance (Bos taurus)
    - EPH-Ephrin signaling (Bos taurus)
      - EPH-ephrin mediated repulsion of cells (Bos taurus)
        
        SFKs phosphorylate VAV2,3 (Bos taurus)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Bos taurus)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Bos taurus)
        
        SRC,FYN,YES,LYN [cytosol] (Bos taurus)
        
        YES1 [cytosol] (Bos taurus)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Bos taurus)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Bos taurus)
        
        SRC,FYN,YES,LYN [cytosol] (Bos taurus)
        
        YES1 [cytosol] (Bos taurus)
        
        SRC,FYN,YES,LYN [cytosol] (Bos taurus)
        
        YES1 [cytosol] (Bos taurus)
        
        TIAM1 exchanges GTP for GDP on RAC1, activating it (Bos taurus)
        
        EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Bos taurus)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Bos taurus)
        
        SRC,FYN,YES,LYN [cytosol] (Bos taurus)
        
        YES1 [cytosol] (Bos taurus)
        
        VAV exchanges GTP for GDP on RAC1, activating it (Bos taurus)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Bos taurus)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Bos taurus)
        
        SRC,FYN,YES,LYN [cytosol] (Bos taurus)
        
        YES1 [cytosol] (Bos taurus)
        
        p-EPHs bind VAV2,3 (Bos taurus)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Bos taurus)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Bos taurus)
        
        SRC,FYN,YES,LYN [cytosol] (Bos taurus)
        
        YES1 [cytosol] (Bos taurus)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Bos taurus)
        
        SRC,FYN,YES,LYN [cytosol] (Bos taurus)
        
        YES1 [cytosol] (Bos taurus)
      - EPHA-mediated growth cone collapse (Bos taurus)
        
        NGEF exchanges GTP for GDP on RHOA (Bos taurus)
        
        EFNAs:p-EPHAs:SFKs:p-Y179-NGEF [plasma membrane] (Bos taurus)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Bos taurus)
        
        SRC,FYN,YES,LYN [cytosol] (Bos taurus)
        
        YES1 [cytosol] (Bos taurus)

Signal Transduction (Bos taurus)

- Signaling by Receptor Tyrosine Kinases (Bos taurus)
  - Signaling by SCF-KIT (Bos taurus)
    - Dimerization of STATs (Bos taurus)
      - p-JAK2:SFKs:p-KIT complex:p-STAT dimers [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        YES1 [cytosol] (Bos taurus)
      - p-JAK2:SFKs:p-KIT complex:p-STATs [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        YES1 [cytosol] (Bos taurus)
    - Disassociation and translocation of STATs to the nucleus (Bos taurus)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        YES1 [cytosol] (Bos taurus)
      - p-JAK2:SFKs:p-KIT complex:p-STAT dimers [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        YES1 [cytosol] (Bos taurus)
    - GRB2 is indirectly recruited to p-KIT through SHP2 (Bos taurus)
      - GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        YES1 [cytosol] (Bos taurus)
      - p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        YES1 [cytosol] (Bos taurus)
    - Indirect recruitment of GAB2 to p-KIT (Bos taurus)
      - GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        YES1 [cytosol] (Bos taurus)
      - GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        YES1 [cytosol] (Bos taurus)
    - Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Bos taurus)
      - PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        YES1 [cytosol] (Bos taurus)
      - p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        YES1 [cytosol] (Bos taurus)
    - JAK2 binds to p-KIT (Bos taurus)
      - JAK2:SFKS:p-KIT complex [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        YES1 [cytosol] (Bos taurus)
      - SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        YES1 [cytosol] (Bos taurus)
    - Phosphorylation and activation of VAV1 (Bos taurus)
      - SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        YES1 [cytosol] (Bos taurus)
      - Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        YES1 [cytosol] (Bos taurus)
    - Phosphorylation of GAB2 by SFKs (Bos taurus)
      - GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        YES1 [cytosol] (Bos taurus)
      - Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        YES1 [cytosol] (Bos taurus)
      - p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        YES1 [cytosol] (Bos taurus)
    - Phosphorylation of JAK2 (Bos taurus)
      - JAK2:SFKS:p-KIT complex [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        YES1 [cytosol] (Bos taurus)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        YES1 [cytosol] (Bos taurus)
    - Phosphorylation of SHP2 by SFKs (Bos taurus)
      - SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        YES1 [cytosol] (Bos taurus)
      - Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        YES1 [cytosol] (Bos taurus)
      - p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        YES1 [cytosol] (Bos taurus)
    - Phosphorylation of STATs (Bos taurus)
      - p-JAK2:SFKs:p-KIT complex:STATs [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        YES1 [cytosol] (Bos taurus)
      - p-JAK2:SFKs:p-KIT complex:p-STATs [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        YES1 [cytosol] (Bos taurus)
    - Phosphorylation of p-KIT on Y900 by Src kinases (Bos taurus)
      - SFKs:p-8Y-KIT:sSCF dimer:p-8Y-KIT [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        YES1 [cytosol] (Bos taurus)
      - SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        YES1 [cytosol] (Bos taurus)
      - Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        YES1 [cytosol] (Bos taurus)
    - Recruitment of STATs (Bos taurus)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        YES1 [cytosol] (Bos taurus)
      - p-JAK2:SFKs:p-KIT complex:STATs [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        YES1 [cytosol] (Bos taurus)
    - Regulation of KIT signaling (Bos taurus)
      - Interaction of APS and p-KIT (Bos taurus)
        
        APS dimer:p-c-Kit:SFKs complex [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        YES1 [cytosol] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        YES1 [cytosol] (Bos taurus)
      - Phosphorylation of APS (Bos taurus)
        
        APS dimer:p-c-Kit:SFKs complex [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        YES1 [cytosol] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        YES1 [cytosol] (Bos taurus)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        YES1 [cytosol] (Bos taurus)
      - Recruitment of CBL to KIT (Bos taurus)
        
        CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane] (Bos taurus)
        
        Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Bos taurus)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        YES1 [cytosol] (Bos taurus)
        
        Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Bos taurus)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        YES1 [cytosol] (Bos taurus)
    - SHP2 interacts with p-KIT (Bos taurus)
      - SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        YES1 [cytosol] (Bos taurus)
      - SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        YES1 [cytosol] (Bos taurus)
    - Synthesis of PIP3 from PIP2 by PI3K (Bos taurus)
      - PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
        
        SFKs:p-KIT complex [plasma membrane] (Bos taurus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Bos taurus)
        
        YES1 [cytosol] (Bos taurus)

External Reference Information

External Reference

UniProt:A7MB57

Gene Names

YES1

Reference Genes

BioGPS Gene:507632 YES1

ENSEMBL:ENSBTAG00000001523.6

KEGG:bta:507632 YES1

Monarch:507632 YES1

NCBI Gene:507632 YES1

UCSC:A7MB57 YES1

Reference Transcript

Participates

as a candidate of

FYN-like kinases [cytosol] (Bos taurus)

as a member of

Other forms of this molecule

phospho-YES1 [plasma membrane]

Inferred From

YES1 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_015315572.1, NP_001094530.1

VGNC

37022

Cite Us!