Reactome | MAD2L1 [cytosol]

MAD2L1 [cytosol]

Stable Identifier

R-SSC-141400

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

cytosol

Synonyms

MAD2L1, A0A286ZJ52

Locations in the PathwayBrowser

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Cell Cycle (Sus scrofa)

- Cell Cycle Checkpoints (Sus scrofa)
  - Mitotic Spindle Checkpoint (Sus scrofa)
    - Amplification of signal from the kinetochores (Sus scrofa)
      - Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Sus scrofa)
        
        MAD2 associates with the Mad1 kinetochore complex (Sus scrofa)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Sus scrofa)
        
        MAD2L1 [cytosol] (Sus scrofa)
        
        Mad1:kinetochore complex [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Mitotic checkpoint complex [cytosol] (Sus scrofa)
        
        MAD2L1 [cytosol] (Sus scrofa)
        
        MAD2L1 [cytosol] (Sus scrofa)
        
        Mad1:kinetochore complex [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Mitotic checkpoint complex [cytosol] (Sus scrofa)
        
        MAD2L1 [cytosol] (Sus scrofa)
        
        MAD2 converted to an inhibitory state via interaction with Mad1 (Sus scrofa)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Sus scrofa)
        
        MAD2L1 [cytosol] (Sus scrofa)
        
        Mad1:kinetochore complex [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Mitotic checkpoint complex [cytosol] (Sus scrofa)
        
        MAD2L1 [cytosol] (Sus scrofa)
        
        Mad1 binds kinetochore (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Mitotic checkpoint complex [cytosol] (Sus scrofa)
        
        MAD2L1 [cytosol] (Sus scrofa)
        
        Mad1:kinetochore complex [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Mitotic checkpoint complex [cytosol] (Sus scrofa)
        
        MAD2L1 [cytosol] (Sus scrofa)
        
        Release of activated MAD2 from kinetochores (Sus scrofa)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Sus scrofa)
        
        MAD2L1 [cytosol] (Sus scrofa)
        
        Mad1:kinetochore complex [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Mitotic checkpoint complex [cytosol] (Sus scrofa)
        
        MAD2L1 [cytosol] (Sus scrofa)
        
        MAD2L1 [cytosol] (Sus scrofa)
        
        Mad1:kinetochore complex [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Mitotic checkpoint complex [cytosol] (Sus scrofa)
        
        MAD2L1 [cytosol] (Sus scrofa)
    - Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Sus scrofa)
      - Inactivation of APC/C via CDC20 sequestration (Sus scrofa)
        
        MAD2*CDC20 complex [cytosol] (Sus scrofa)
        
        MAD2L1 [cytosol] (Sus scrofa)
        
        MAD2L1 [cytosol] (Sus scrofa)
      - Inactivation of APC/C via direct inhibition of the APC/C complex (Sus scrofa)
        
        Binding of the MCC complex to the APC/C complex (Sus scrofa)
        
        MCC:APC/C complex [cytosol] (Sus scrofa)
        
        Mitotic checkpoint complex [cytosol] (Sus scrofa)
        
        MAD2L1 [cytosol] (Sus scrofa)
        
        Mitotic checkpoint complex [cytosol] (Sus scrofa)
        
        MAD2L1 [cytosol] (Sus scrofa)
        
        Formation of the MCC complex (Sus scrofa)
        
        MAD2L1 [cytosol] (Sus scrofa)
        
        Mitotic checkpoint complex [cytosol] (Sus scrofa)
        
        MAD2L1 [cytosol] (Sus scrofa)
- Cell Cycle, Mitotic (Sus scrofa)
  - M Phase (Sus scrofa)
    - Mitotic Metaphase and Anaphase (Sus scrofa)
      - Mitotic Anaphase (Sus scrofa)
        
        Separation of Sister Chromatids (Sus scrofa)
        
        ESPL1 (Separase) cleaves centromeric cohesin (Sus scrofa)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Mitotic checkpoint complex [cytosol] (Sus scrofa)
        
        MAD2L1 [cytosol] (Sus scrofa)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Sus scrofa)
        
        Microtubule-bound kinetochore [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Mitotic checkpoint complex [cytosol] (Sus scrofa)
        
        MAD2L1 [cytosol] (Sus scrofa)
        
        Separation of sister chromatids (Sus scrofa)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Mitotic checkpoint complex [cytosol] (Sus scrofa)
        
        MAD2L1 [cytosol] (Sus scrofa)
        
        Sister Centromere:Kinetochore:Microtubules [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Mitotic checkpoint complex [cytosol] (Sus scrofa)
        
        MAD2L1 [cytosol] (Sus scrofa)
    - Mitotic Prometaphase (Sus scrofa)
      - EML4 and NUDC in mitotic spindle formation (Sus scrofa)
        
        EML4 recruits NUDC to mitotic spindle (Sus scrofa)
        
        Microtubule-bound kinetochore [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Mitotic checkpoint complex [cytosol] (Sus scrofa)
        
        MAD2L1 [cytosol] (Sus scrofa)
        
        p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Sus scrofa)
        
        Microtubule-bound kinetochore [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Mitotic checkpoint complex [cytosol] (Sus scrofa)
        
        MAD2L1 [cytosol] (Sus scrofa)
      - Kinetochore capture of astral microtubules (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Mitotic checkpoint complex [cytosol] (Sus scrofa)
        
        MAD2L1 [cytosol] (Sus scrofa)
        
        Microtubule-bound kinetochore [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Mitotic checkpoint complex [cytosol] (Sus scrofa)
        
        MAD2L1 [cytosol] (Sus scrofa)
      - Resolution of Sister Chromatid Cohesion (Sus scrofa)
        
        CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Sus scrofa)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Sus scrofa)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Sus scrofa)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Mitotic checkpoint complex [cytosol] (Sus scrofa)
        
        MAD2L1 [cytosol] (Sus scrofa)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Mitotic checkpoint complex [cytosol] (Sus scrofa)
        
        MAD2L1 [cytosol] (Sus scrofa)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Sus scrofa)
        
        Microtubule-bound kinetochore [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Mitotic checkpoint complex [cytosol] (Sus scrofa)
        
        MAD2L1 [cytosol] (Sus scrofa)
        
        Kinetochore assembly (Sus scrofa)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Sus scrofa)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Sus scrofa)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Mitotic checkpoint complex [cytosol] (Sus scrofa)
        
        MAD2L1 [cytosol] (Sus scrofa)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Mitotic checkpoint complex [cytosol] (Sus scrofa)
        
        MAD2L1 [cytosol] (Sus scrofa)
        
        Microtubule-bound kinetochore [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Mitotic checkpoint complex [cytosol] (Sus scrofa)
        
        MAD2L1 [cytosol] (Sus scrofa)
        
        PP2A-B56 dephosphorylates centromeric cohesin (Sus scrofa)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Sus scrofa)
        
        Microtubule-bound kinetochore [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Mitotic checkpoint complex [cytosol] (Sus scrofa)
        
        MAD2L1 [cytosol] (Sus scrofa)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Sus scrofa)
        
        Microtubule-bound kinetochore [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Mitotic checkpoint complex [cytosol] (Sus scrofa)
        
        MAD2L1 [cytosol] (Sus scrofa)
        
        Phosphorylation of cohesin by PLK1 at centromeres (Sus scrofa)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Sus scrofa)
        
        Microtubule-bound kinetochore [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Mitotic checkpoint complex [cytosol] (Sus scrofa)
        
        MAD2L1 [cytosol] (Sus scrofa)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Sus scrofa)
        
        Microtubule-bound kinetochore [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Mitotic checkpoint complex [cytosol] (Sus scrofa)
        
        MAD2L1 [cytosol] (Sus scrofa)
  - Regulation of mitotic cell cycle (Sus scrofa)
    - APC/C-mediated degradation of cell cycle proteins (Sus scrofa)
      - Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Sus scrofa)
        
        APC/C:Cdc20 mediated degradation of mitotic proteins (Sus scrofa)
        
        APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Sus scrofa)
        
        APC-Cdc20 mediated degradation of Nek2A (Sus scrofa)
        
        Degradation of multiubiquitinated Nek2A (Sus scrofa)
        
        MCC:APC/C complex [cytosol] (Sus scrofa)
        
        Mitotic checkpoint complex [cytosol] (Sus scrofa)
        
        MAD2L1 [cytosol] (Sus scrofa)
        
        Multiubiquitinated Nek2A [cytosol] (Sus scrofa)
        
        Nek2A:MCC:APC/C complex [cytosol] (Sus scrofa)
        
        MCC:APC/C complex [cytosol] (Sus scrofa)
        
        Mitotic checkpoint complex [cytosol] (Sus scrofa)
        
        MAD2L1 [cytosol] (Sus scrofa)
        
        Multiubiquitination of Nek2A (Sus scrofa)
        
        Multiubiquitinated Nek2A [cytosol] (Sus scrofa)
        
        Nek2A:MCC:APC/C complex [cytosol] (Sus scrofa)
        
        MCC:APC/C complex [cytosol] (Sus scrofa)
        
        Mitotic checkpoint complex [cytosol] (Sus scrofa)
        
        MAD2L1 [cytosol] (Sus scrofa)
        
        Nek2A:MCC:APC/C complex [cytosol] (Sus scrofa)
        
        MCC:APC/C complex [cytosol] (Sus scrofa)
        
        Mitotic checkpoint complex [cytosol] (Sus scrofa)
        
        MAD2L1 [cytosol] (Sus scrofa)
        
        Cdc20:Phospho-APC/C mediated degradation of Cyclin A (Sus scrofa)
        
        Association of Cyclin A with the APC/C (Sus scrofa)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Sus scrofa)
        
        MCC:APC/C complex [cytosol] (Sus scrofa)
        
        Mitotic checkpoint complex [cytosol] (Sus scrofa)
        
        MAD2L1 [cytosol] (Sus scrofa)
        
        MCC:APC/C complex [cytosol] (Sus scrofa)
        
        Mitotic checkpoint complex [cytosol] (Sus scrofa)
        
        MAD2L1 [cytosol] (Sus scrofa)
        
        Degradation multiubiquitinated Cyclin A (Sus scrofa)
        
        MCC:APC/C complex [cytosol] (Sus scrofa)
        
        Mitotic checkpoint complex [cytosol] (Sus scrofa)
        
        MAD2L1 [cytosol] (Sus scrofa)
        
        multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Sus scrofa)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Sus scrofa)
        
        MCC:APC/C complex [cytosol] (Sus scrofa)
        
        Mitotic checkpoint complex [cytosol] (Sus scrofa)
        
        MAD2L1 [cytosol] (Sus scrofa)
        
        Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Sus scrofa)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Sus scrofa)
        
        MCC:APC/C complex [cytosol] (Sus scrofa)
        
        Mitotic checkpoint complex [cytosol] (Sus scrofa)
        
        MAD2L1 [cytosol] (Sus scrofa)
        
        MCC:APC/C complex [cytosol] (Sus scrofa)
        
        Mitotic checkpoint complex [cytosol] (Sus scrofa)
        
        MAD2L1 [cytosol] (Sus scrofa)
        
        multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Sus scrofa)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Sus scrofa)
        
        MCC:APC/C complex [cytosol] (Sus scrofa)
        
        Mitotic checkpoint complex [cytosol] (Sus scrofa)
        
        MAD2L1 [cytosol] (Sus scrofa)
        
        Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Sus scrofa)
        
        MCC:APC/C complex [cytosol] (Sus scrofa)
        
        Mitotic checkpoint complex [cytosol] (Sus scrofa)
        
        MAD2L1 [cytosol] (Sus scrofa)
        
        hBUBR1:hBUB3:MAD2* complex [cytosol] (Sus scrofa)
        
        MAD2L1 [cytosol] (Sus scrofa)
      - Regulation of APC/C activators between G1/S and early anaphase (Sus scrofa)
        
        Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Sus scrofa)
        
        Inactivation of APC/C via CDC20 sequestration (Sus scrofa)
        
        MAD2*CDC20 complex [cytosol] (Sus scrofa)
        
        MAD2L1 [cytosol] (Sus scrofa)
        
        MAD2L1 [cytosol] (Sus scrofa)
        
        Inactivation of APC/C via direct inhibition of the APC/C complex (Sus scrofa)
        
        Binding of the MCC complex to the APC/C complex (Sus scrofa)
        
        MCC:APC/C complex [cytosol] (Sus scrofa)
        
        Mitotic checkpoint complex [cytosol] (Sus scrofa)
        
        MAD2L1 [cytosol] (Sus scrofa)
        
        Mitotic checkpoint complex [cytosol] (Sus scrofa)
        
        MAD2L1 [cytosol] (Sus scrofa)
        
        Formation of the MCC complex (Sus scrofa)
        
        MAD2L1 [cytosol] (Sus scrofa)
        
        Mitotic checkpoint complex [cytosol] (Sus scrofa)
        
        MAD2L1 [cytosol] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A286ZJ52

Gene Names

MAD2L1

Reference Genes

BioGPS Gene:100523455 MAD2L1

ENSEMBL:ENSSSCG00000036256.3

KEGG:ssc:100523455 MAD2L1

Monarch:100523455 MAD2L1

NCBI Gene:100523455 MAD2L1

UCSC:A0A286ZJ52 MAD2L1

Reference Transcript

RefSeq:XM_003129223.3 MAD2L1

Other Identifiers

100523455

GO:0000132

GO:0000278

GO:0000776

GO:0005634

GO:0005635

GO:0005654

GO:0005694

GO:0005737

GO:0005829

GO:0005856

GO:0007010

GO:0007059

GO:0007094

GO:0007163

GO:0012501

GO:0023052

GO:0030163

GO:0033597

GO:0042177

GO:0042802

GO:0042803

GO:0043066

GO:0043226

GO:0044615

GO:0045930

GO:0048471

GO:0051660

GO:0072686

GO:0090267

GO:0140014

GO:1990728

Ssc.5129.1.S1_at

Participates

as an input of

as a component of

as an output of

Release of activated MAD2 from kinetochores (Sus scrofa)

Inferred From

Activated MAD2L1 [cytosol] (Homo sapiens)

MAD2L1 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_003129271.1

ENSEMBL

ENSSSCG00000036256, ENSSSCT00000052270, ENSSSCP00000031508

VGNC

89939

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