Formation of the MCC complex

Stable Identifier
R-HSA-141437
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Upon release from the kinetochore, Mad2 associates with Cdc20, hBUBR1, and hBUB3 to form the Mitotic Checkpoint Complex (MCC). Assembly of this complex does not depend on kinetochores but this complex can only inhibit APC/C that has undergone mitotic modifications.

Literature References
PubMed ID Title Journal Year
11535616 Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2

Sudakin, V, Chan, GK, Yen, TJ

J Cell Biol 2001
Participants
Participant Of
Orthologous Events
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Created