Formation of the MCC complex

Stable Identifier
R-HSA-141437
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Formation of the MCC complex
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Upon release from the kinetochore, Mad2 associates with Cdc20, hBUBR1, and hBUB3 to form the Mitotic Checkpoint Complex (MCC). Assembly of this complex does not depend on kinetochores but this complex can only inhibit APC/C that has undergone mitotic modifications.
Literature References
PubMed ID Title Journal Year
11535616 Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2

Yen, TJ, Sudakin, V, Chan, GK

J Cell Biol 2001
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Orthologous Events
Formation of the MCC complex (Bos taurus)
Formation of the MCC complex (Caenorhabditis elegans)
Formation of the MCC complex (Canis familiaris)
Formation of the MCC complex (Dictyostelium discoideum)
Formation of the MCC complex (Drosophila melanogaster)
Formation of the MCC complex (Gallus gallus)
Formation of the MCC complex (Mus musculus)
Formation of the MCC complex (Saccharomyces cerevisiae)
Formation of the MCC complex (Schizosaccharomyces pombe)
Formation of the MCC complex (Sus scrofa)
Formation of the MCC complex (Xenopus tropicalis)
Authored
Yen, TJ  (2004-05-05)
Reviewed
Peters, JM  (2006-03-28)
Created
Yen, TJ  (2004-05-05)
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