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About
What is Reactome ?
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Digital Preservation
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POLA1 [nucleoplasm]
Stable Identifier
R-HSA-68487
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
p180, DNA polymerase alpha catalytic subunit
Icon
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
Activation of the pre-replicative complex (Homo sapiens)
DNA polymerase alpha:primase binds at the origin (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase:DNA polymerase alpha:origin complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
E2F mediated regulation of DNA replication (Homo sapiens)
Inhibition of replication initiation of damaged DNA by RB1/E2F1 (Homo sapiens)
Detection of damage during initiation of DNA synthesis in S-phase (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
G1/S-Specific Transcription (Homo sapiens)
POLA1 gene transcription is stimulated by E2F1 (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Synthesis of DNA (Homo sapiens)
DNA replication initiation (Homo sapiens)
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase:DNA polymerase alpha:origin complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
DNA strand elongation (Homo sapiens)
Lagging Strand Synthesis (Homo sapiens)
Polymerase switching (Homo sapiens)
Formation of Processive Complex (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
Loading of PCNA - Sliding Clamp Formation (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:origin duplex:PCNA homotrimer [nucleoplasm] (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
RFC binding displaces Pol Alpha (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
RFC dissociates after sliding clamp formation (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:origin duplex:PCNA homotrimer [nucleoplasm] (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
Processive synthesis on the lagging strand (Homo sapiens)
Formation of Okazaki fragments (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment complex [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
Formation of the Flap Intermediate (Homo sapiens)
Processive complex:Okazaki fragment complex [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment:Flap [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment complex [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
Removal of the Flap Intermediate (Homo sapiens)
RPA binds to the Flap (Homo sapiens)
Processive complex:Okazaki fragment:Flap [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment complex [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment:Flap [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment complex [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
Recruitment of Dna2 endonuclease (Homo sapiens)
Processive complex:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment:Flap [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment complex [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment:Flap:RPA heterotrimer:dna2 [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment:Flap [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment complex [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
Removal of RNA primer and dissociation of RPA and Dna2 (Homo sapiens)
Processive complex:Okazaki fragment:Flap:RPA heterotrimer:dna2 [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment:Flap [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment complex [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragments:Remaining Flap [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
Removal of remaining Flap (Homo sapiens)
Processive complex:Okazaki fragments:Remaining Flap [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
Processive complex:nicked DNA from adjacent Okazaki fragments [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
Leading Strand Synthesis (Homo sapiens)
Polymerase switching (Homo sapiens)
Formation of Processive Complex (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
Loading of PCNA - Sliding Clamp Formation (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:origin duplex:PCNA homotrimer [nucleoplasm] (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
RFC binding displaces Pol Alpha (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
RFC dissociates after sliding clamp formation (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:origin duplex:PCNA homotrimer [nucleoplasm] (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
Chromosome Maintenance (Homo sapiens)
Telomere Maintenance (Homo sapiens)
Extension of Telomeres (Homo sapiens)
Telomere C-strand (Lagging Strand) Synthesis (Homo sapiens)
Polymerase switching on the C-strand of the telomere (Homo sapiens)
RFC binding displaces Pol Alpha on the C-strand of the telomere (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
RNA primer:DNA primer:G-strand extended telomere:POLA:primase [nucleoplasm] (Homo sapiens)
RNA primer:G-strand extended telomere end:POLA:primase [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
Telomere C-strand synthesis initiation (Homo sapiens)
DNA polymerase:primase binds G-strand of the telomere (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
POLA:primase:G-strand extended telomere end [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
RNA primer:DNA primer:G-strand extended telomere:POLA:primase [nucleoplasm] (Homo sapiens)
RNA primer:G-strand extended telomere end:POLA:primase [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
RNA primer:G-strand extended telomere end:POLA:primase [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere (Homo sapiens)
POLA:primase:G-strand extended telomere end [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
RNA primer:G-strand extended telomere end:POLA:primase [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
DNA Replication (Homo sapiens)
DNA Replication Pre-Initiation (Homo sapiens)
Activation of the pre-replicative complex (Homo sapiens)
DNA polymerase alpha:primase binds at the origin (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase:DNA polymerase alpha:origin complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
Synthesis of DNA (Homo sapiens)
DNA replication initiation (Homo sapiens)
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase:DNA polymerase alpha:origin complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
DNA strand elongation (Homo sapiens)
Lagging Strand Synthesis (Homo sapiens)
Polymerase switching (Homo sapiens)
Formation of Processive Complex (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
Loading of PCNA - Sliding Clamp Formation (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:origin duplex:PCNA homotrimer [nucleoplasm] (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
RFC binding displaces Pol Alpha (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
RFC dissociates after sliding clamp formation (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:origin duplex:PCNA homotrimer [nucleoplasm] (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
Processive synthesis on the lagging strand (Homo sapiens)
Formation of Okazaki fragments (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment complex [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
Formation of the Flap Intermediate (Homo sapiens)
Processive complex:Okazaki fragment complex [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment:Flap [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment complex [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
Removal of the Flap Intermediate (Homo sapiens)
RPA binds to the Flap (Homo sapiens)
Processive complex:Okazaki fragment:Flap [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment complex [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment:Flap [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment complex [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
Recruitment of Dna2 endonuclease (Homo sapiens)
Processive complex:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment:Flap [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment complex [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment:Flap:RPA heterotrimer:dna2 [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment:Flap [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment complex [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
Removal of RNA primer and dissociation of RPA and Dna2 (Homo sapiens)
Processive complex:Okazaki fragment:Flap:RPA heterotrimer:dna2 [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment:Flap [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment complex [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragments:Remaining Flap [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
Removal of remaining Flap (Homo sapiens)
Processive complex:Okazaki fragments:Remaining Flap [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
Processive complex:nicked DNA from adjacent Okazaki fragments [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
Leading Strand Synthesis (Homo sapiens)
Polymerase switching (Homo sapiens)
Formation of Processive Complex (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
Loading of PCNA - Sliding Clamp Formation (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:origin duplex:PCNA homotrimer [nucleoplasm] (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
RFC binding displaces Pol Alpha (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
RFC dissociates after sliding clamp formation (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:origin duplex:PCNA homotrimer [nucleoplasm] (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
Disease (Homo sapiens)
Diseases of programmed cell death (Homo sapiens)
Defective pyroptosis (Homo sapiens)
Decitabine triphosphate incorporates into DNA (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
RNA primer:decitabine-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P09884 POLA1
Gene Names
POLA1, POLA
Chain
chain:1-1462
Reference Genes
BioGPS Gene:5422 POLA1
COSMIC (genes):POLA1 POLA1
CTD Gene:5422 POLA1
dbSNP Gene:5422 POLA1
ENSEMBL:ENSG00000101868 POLA1
HGNC:9173 POLA1
KEGG:hsa:5422 POLA1
Monarch:5422 POLA1
NCBI Gene:5422 POLA1
OMIM:312040 POLA1
UCSC:P09884 POLA1
Reference Transcript
RefSeq:NM_016937.3 POLA1
Other Identifiers
11726156_at
17102230
17102272
204835_PM_at
204835_at
3745479
3972092
3972094
3972095
3972098
3972099
3972101
3972102
3972103
3972104
3972105
3972106
3972107
3972108
3972110
3972111
3972112
3972113
3972114
3972115
3972116
3972117
3972118
3972119
3972120
3972121
3972122
3972123
3972124
3972126
3972127
3972128
3972129
3972130
3972131
3972138
3972147
3972149
3972150
3972152
3972153
3972155
3972156
3972158
3972159
3972160
3972166
3972174
3972189
3972190
3972205
3972207
3972209
5422
786_at
8166525
8166563
A_14_P116005
A_21_P0000353
A_32_P1701
A_33_P3737979
GE62468
GO:0000166
GO:0000731
GO:0000785
GO:0003676
GO:0003677
GO:0003682
GO:0003688
GO:0003697
GO:0003824
GO:0003887
GO:0005515
GO:0005634
GO:0005635
GO:0005654
GO:0005658
GO:0005730
GO:0005737
GO:0005829
GO:0006259
GO:0006260
GO:0006261
GO:0006269
GO:0006270
GO:0006271
GO:0006272
GO:0006273
GO:0006281
GO:0006303
GO:0008270
GO:0016363
GO:0016740
GO:0019901
GO:0031981
GO:0032479
GO:0043226
GO:0046872
GO:0140097
GO:1902975
HMNXSV003009756
HMNXSV003018604
HMNXSV003019039
ILMN_2191436
PH_hs_0013709
RNA33523|snoRNA_scaRNA_119_130
TC0X000120.hg
TC0X000121.hg
X06745_at
g8393994_3p_at
p25626
p27852
p27853
Participates
as an output of
POLA1 gene transcription is stimulated by E2F1 (Homo sapiens)
as a component of
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
Inferred To
pola-1 [nucleoplasm]
(Caenorhabditis elegans)
POLA1 [nucleoplasm]
(Bos taurus)
POLA1 [nucleoplasm]
(Canis familiaris)
POLA1 [nucleoplasm]
(Dictyostelium discoideum)
POLA1 [nucleoplasm]
(Drosophila melanogaster)
POLA1 [nucleoplasm]
(Gallus gallus)
POLA1 [nucleoplasm]
(Mus musculus)
POLA1 [nucleoplasm]
(Plasmodium falciparum)
POLA1 [nucleoplasm]
(Rattus norvegicus)
POLA1 [nucleoplasm]
(Saccharomyces cerevisiae)
POLA1 [nucleoplasm]
(Schizosaccharomyces pombe)
POLA1 [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
NP_058633.2
OpenTargets
ENSG00000101868
ENSEMBL
ENST00000379059
,
ENSP00000368349
ZINC - Substances
DPOLA_HUMAN
ZINC target
P09884
ZINC - Biogenic
DPOLA_HUMAN
PRO
P09884
GlyGen
P09884
PDB
5IUD
,
8D96
,
4Y97
,
5EXR
,
8QJ7
,
7N2M
,
6AS7
,
7OPL
,
4QCL
,
7U5C
,
8D0K
,
8D0B
,
1N5G
,
1K0P
,
8D9D
,
8B9D
,
4Q5V
,
1K18
HPA
ENSG00000101868-POLA1
Pharos - Targets
P09884
Orphanet
POLA1
ZINC - Predictions - Purchasable
DPOLA_HUMAN
HMDB Protein
HMDBP00951
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P03070 LT
0.767
8
UniProt:P0DTD1-PRO_0000449619 REP
0.671
5
UniProt:P49642 PRIM1
1
PRIM1 [nucleoplasm]
(R-HSA-68497)
0.643
3
UniProt:P10193 OBP
0.563
4
UniProt:P0C6X7-PRO_0000037309 REP
0.527
2
UniProt:P04014 VE1
0.454
2
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