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POLA2 [nucleoplasm]
Stable Identifier
R-HSA-68493
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
p70, DNA polymerase alpha 70 kDa subunit, DNA polymerase subunit B
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
Activation of the pre-replicative complex (Homo sapiens)
DNA polymerase alpha:primase binds at the origin (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase:DNA polymerase alpha:origin complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
E2F mediated regulation of DNA replication (Homo sapiens)
Inhibition of replication initiation of damaged DNA by RB1/E2F1 (Homo sapiens)
Detection of damage during initiation of DNA synthesis in S-phase (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Synthesis of DNA (Homo sapiens)
DNA replication initiation (Homo sapiens)
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase:DNA polymerase alpha:origin complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
DNA strand elongation (Homo sapiens)
Lagging Strand Synthesis (Homo sapiens)
Polymerase switching (Homo sapiens)
Formation of Processive Complex (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
Loading of PCNA - Sliding Clamp Formation (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:origin duplex:PCNA homotrimer [nucleoplasm] (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
RFC binding displaces Pol Alpha (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
RFC dissociates after sliding clamp formation (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:origin duplex:PCNA homotrimer [nucleoplasm] (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
Processive synthesis on the lagging strand (Homo sapiens)
Formation of Okazaki fragments (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment complex [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
Formation of the Flap Intermediate (Homo sapiens)
Processive complex:Okazaki fragment complex [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment:Flap [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment complex [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
Removal of the Flap Intermediate (Homo sapiens)
RPA binds to the Flap (Homo sapiens)
Processive complex:Okazaki fragment:Flap [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment complex [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment:Flap [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment complex [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
Recruitment of Dna2 endonuclease (Homo sapiens)
Processive complex:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment:Flap [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment complex [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment:Flap:RPA heterotrimer:dna2 [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment:Flap [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment complex [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
Removal of RNA primer and dissociation of RPA and Dna2 (Homo sapiens)
Processive complex:Okazaki fragment:Flap:RPA heterotrimer:dna2 [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment:Flap [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment complex [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragments:Remaining Flap [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
Removal of remaining Flap (Homo sapiens)
Processive complex:Okazaki fragments:Remaining Flap [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
Processive complex:nicked DNA from adjacent Okazaki fragments [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
Leading Strand Synthesis (Homo sapiens)
Polymerase switching (Homo sapiens)
Formation of Processive Complex (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
Loading of PCNA - Sliding Clamp Formation (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:origin duplex:PCNA homotrimer [nucleoplasm] (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
RFC binding displaces Pol Alpha (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
RFC dissociates after sliding clamp formation (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:origin duplex:PCNA homotrimer [nucleoplasm] (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
Chromosome Maintenance (Homo sapiens)
Telomere Maintenance (Homo sapiens)
Extension of Telomeres (Homo sapiens)
Telomere C-strand (Lagging Strand) Synthesis (Homo sapiens)
Polymerase switching on the C-strand of the telomere (Homo sapiens)
RFC binding displaces Pol Alpha on the C-strand of the telomere (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
RNA primer:DNA primer:G-strand extended telomere:POLA:primase [nucleoplasm] (Homo sapiens)
RNA primer:G-strand extended telomere end:POLA:primase [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
Telomere C-strand synthesis initiation (Homo sapiens)
DNA polymerase:primase binds G-strand of the telomere (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
POLA:primase:G-strand extended telomere end [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
RNA primer:DNA primer:G-strand extended telomere:POLA:primase [nucleoplasm] (Homo sapiens)
RNA primer:G-strand extended telomere end:POLA:primase [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
RNA primer:G-strand extended telomere end:POLA:primase [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere (Homo sapiens)
POLA:primase:G-strand extended telomere end [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
RNA primer:G-strand extended telomere end:POLA:primase [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
DNA Replication (Homo sapiens)
DNA Replication Pre-Initiation (Homo sapiens)
Activation of the pre-replicative complex (Homo sapiens)
DNA polymerase alpha:primase binds at the origin (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase:DNA polymerase alpha:origin complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
Synthesis of DNA (Homo sapiens)
DNA replication initiation (Homo sapiens)
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase:DNA polymerase alpha:origin complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
DNA strand elongation (Homo sapiens)
Lagging Strand Synthesis (Homo sapiens)
Polymerase switching (Homo sapiens)
Formation of Processive Complex (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
Loading of PCNA - Sliding Clamp Formation (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:origin duplex:PCNA homotrimer [nucleoplasm] (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
RFC binding displaces Pol Alpha (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
RFC dissociates after sliding clamp formation (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:origin duplex:PCNA homotrimer [nucleoplasm] (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
Processive synthesis on the lagging strand (Homo sapiens)
Formation of Okazaki fragments (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment complex [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
Formation of the Flap Intermediate (Homo sapiens)
Processive complex:Okazaki fragment complex [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment:Flap [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment complex [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
Removal of the Flap Intermediate (Homo sapiens)
RPA binds to the Flap (Homo sapiens)
Processive complex:Okazaki fragment:Flap [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment complex [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment:Flap [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment complex [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
Recruitment of Dna2 endonuclease (Homo sapiens)
Processive complex:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment:Flap [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment complex [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment:Flap:RPA heterotrimer:dna2 [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment:Flap [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment complex [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
Removal of RNA primer and dissociation of RPA and Dna2 (Homo sapiens)
Processive complex:Okazaki fragment:Flap:RPA heterotrimer:dna2 [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment:Flap [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment complex [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragments:Remaining Flap [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
Removal of remaining Flap (Homo sapiens)
Processive complex:Okazaki fragments:Remaining Flap [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
Processive complex:nicked DNA from adjacent Okazaki fragments [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
Leading Strand Synthesis (Homo sapiens)
Polymerase switching (Homo sapiens)
Formation of Processive Complex (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
Loading of PCNA - Sliding Clamp Formation (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:origin duplex:PCNA homotrimer [nucleoplasm] (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
RFC binding displaces Pol Alpha (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
RFC dissociates after sliding clamp formation (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:origin duplex:PCNA homotrimer [nucleoplasm] (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
Disease (Homo sapiens)
Diseases of programmed cell death (Homo sapiens)
Defective pyroptosis (Homo sapiens)
Decitabine triphosphate incorporates into DNA (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
RNA primer:decitabine-DNA primer:origin duplex [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
POLA2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14181 POLA2
Gene Names
POLA2
Chain
chain:1-598
Reference Genes
BioGPS Gene:23649 POLA2
COSMIC (genes):POLA2 POLA2
CTD Gene:23649 POLA2
dbSNP Gene:23649 POLA2
ENSEMBL:ENSG00000014138 POLA2
HGNC:30073 POLA2
KEGG:hsa:23649 POLA2
Monarch:23649 POLA2
NCBI Gene:23649 POLA2
OMIM:620063 POLA2
UCSC:Q14181 POLA2
Reference Transcript
RefSeq:NM_002689.3 POLA2
Other Identifiers
11717667_a_at
11746633_a_at
16726790
1775_at
204441_PM_s_at
204441_s_at
23649
236546_PM_at
236546_at
244575_PM_at
244575_at
3335030
3335031
3335032
3335033
3335034
3335035
3335036
3335037
3335038
3335039
3335040
3335041
3335042
3335043
3335044
3335047
3335048
3335049
3335050
3335051
3335052
3335053
3335054
3335055
3335056
3335057
3335058
3335059
3335060
3335061
3335062
3335067
7941214
81776_at
A_14_P114156
A_14_P125349
A_23_P161615
GE57685
GE886941
GO:0003674
GO:0003677
GO:0005515
GO:0005634
GO:0005654
GO:0005658
GO:0005829
GO:0006260
GO:0006269
GO:0006270
GO:0006606
GO:0006886
GO:0006913
GO:0043226
HMNXSV003020459
HMNXSV003030492
Hs.159611.0.A1_3p_at
ILMN_1696713
L24559_at
PH_hs_0016795
PH_hs_0022995
TC11000622.hg
g4505928_3p_a_at
Participates
as a component of
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
Inferred To
div-1 [nucleoplasm]
(Caenorhabditis elegans)
PolA2 [nucleoplasm]
(Drosophila melanogaster)
Ghost homologue of POLA2 [nucleoplasm]
(Gallus gallus)
spb70 [nucleoplasm]
(Schizosaccharomyces pombe)
POLA2 [nucleoplasm]
(Bos taurus)
POLA2 [nucleoplasm]
(Canis familiaris)
POLA2 [nucleoplasm]
(Plasmodium falciparum)
POLA2 [nucleoplasm]
(Sus scrofa)
POL12 [nucleoplasm]
(Saccharomyces cerevisiae)
polA2 [nucleoplasm]
(Dictyostelium discoideum)
Pola2 [nucleoplasm]
(Mus musculus)
Pola2 [nucleoplasm]
(Rattus norvegicus)
Cross References
RefSeq
NP_002680.2
ENSEMBL
ENST00000265465
,
ENSP00000265465
OpenTargets
ENSG00000014138
HPA
ENSG00000014138-POLA2
PRO
Q14181
Pharos - Targets
Q14181
GlyGen
Q14181
HMDB Protein
HMDBP00963
PDB
4E2I
,
4Y97
,
2KEB
,
8B9D
,
8D9D
,
5EXR
,
8D0K
,
8D0B
,
7U5C
,
7OPL
,
8QJ7
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P55212 CASP6
5
CASP6(194-293) [cytosol]
(R-HSA-266128)
CASP6(24-179) [cytosol]
(R-HSA-350313)
CASP6(24-179) [nucleoplasm]
(R-HSA-352247)
CASP6(194-293) [nucleoplasm]
(R-HSA-352246)
CASP6 (1-293) [cytosol]
(R-HSA-6798132)
0.556
3
UniProt:P31948 STIP1
1
STIP1 [cytosol]
(R-HSA-443857)
0.556
3
UniProt:P54652 HSPA2
2
HSPA2 [cytosol]
(R-HSA-3371408)
HSPA2 [nucleoplasm]
(R-HSA-912480)
0.556
3
UniProt:Q9H668 STN1
1
STN1 [nucleoplasm]
(R-HSA-9668821)
0.527
2
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