Reactome | CDC23 [nucleoplasm]

CDC23 [nucleoplasm]

Stable Identifier

R-HSA-174228

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Apc8/Cdc23

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Diseases of mitotic cell cycle (Homo sapiens)
  - Aberrant regulation of mitotic cell cycle due to RB1 defects (Homo sapiens)
    - Aberrant regulation of mitotic exit in cancer due to RB1 defects (Homo sapiens)
      - Defective RB1 does not form a complex with SKP2 and FZR1 (Homo sapiens)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
        
        CDC23 [nucleoplasm] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by VENTX (Homo sapiens)
      - Regulation of IL6 transcription (Homo sapiens)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
        
        CDC23 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UJX2 CDC23

Gene Names

CDC23, ANAPC8

Chain

initiator methionine:, chain:2-597

Reference Genes

BioGPS Gene:8697 CDC23

COSMIC (genes):CDC23 CDC23

CTD Gene:8697 CDC23

dbSNP Gene:8697 CDC23

ENSEMBL:ENSG00000094880 CDC23

HGNC:1724 CDC23

KEGG:hsa:8697 CDC23

Monarch:8697 CDC23

NCBI Gene:8697 CDC23

OMIM:603462 CDC23

UCSC:Q9UJX2 CDC23

Reference Transcript

RefSeq:NM_004661.4 CDC23

Other Identifiers

11721444_a_at

11752517_a_at

11757838_s_at

11759740_x_at

17000404

202892_PM_at

202892_at

223651_PM_x_at

223651_x_at

2877316

2877317

2877318

2877319

2877320

2877321

2877325

2877326

2877327

2877328

2877329

2877330

2877332

2877333

2877334

2877335

2877336

2877337

2877338

2877339

2877340

2877341

2877342

2877343

2877345

31877_at

3250677

68170_r_at

8114396

8697

A_23_P133629

A_24_P913227

GE54494

GO:0000278

GO:0003824

GO:0004842

GO:0005515

GO:0005654

GO:0005680

GO:0005829

GO:0006511

GO:0007080

GO:0007091

GO:0007096

GO:0007346

GO:0016567

GO:0016740

GO:0030071

GO:0030163

GO:0031145

GO:0045842

GO:0051301

GO:0051445

GO:0070936

GO:0070979

GO:0140096

GO:0141198

HMNXSV003025907

HMNXSV003049724

ILMN_1799688

PH_hs_0009232

TC05001827.hg

g13528932_3p_at

g4757947_3p_at

Participates

as a component of

Other forms of this molecule

CDC23 [cytosol]

Inferred To

CDC23 [nucleoplasm] (Bos taurus)

CDC23 [nucleoplasm] (Canis familiaris)

CDC23 [nucleoplasm] (Gallus gallus)

CDC23 [nucleoplasm] (Sus scrofa)

Cdc23 [nucleoplasm] (Drosophila melanogaster)

Cdc23 [nucleoplasm] (Mus musculus)

Cdc23 [nucleoplasm] (Rattus norvegicus)

anapc8 [nucleoplasm] (Dictyostelium discoideum)

cdc23 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_004652.2

OpenTargets

ENSG00000094880

ENSEMBL

ENSP00000378350, ENSG00000094880, ENSP00000378348, ENST00000394886, ENST00000394884

HPA

ENSG00000094880-CDC23

GeneCards

CDC23

PRO

Q9UJX2

Pharos - Targets

Q9UJX2

GlyGen

Q9UJX2

PDB

8PKP, 9GAW, 6TLJ, 5G05, 5G04, 8TAR, 6Q6H, 6Q6G, 5L9T, 4UI9, 5A31, 5LCW, 6TNT, 6TM5, 5L9U, 8TAU, 5KHU, 5KHR

Interactors (23)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96CV9 OPTN	6	p-S177,S473,S513-OPTN [cytosol] (R-HSA-9687840) OPTN [cytosol] (R-HSA-9687907) p-S177-OPTN [cytosol] (R-HSA-2562525) p-S177-OPTN [nucleoplasm] (R-HSA-2562595) OPTN [Golgi membrane] (R-HSA-2161111) OPTN [recycling endosome membrane] (R-HSA-8854141)	0.795	8
UniProt:O60566 BUB1B	1	BUB1B [cytosol] (R-HSA-141436)	0.788	5
UniProt:Q9UM11 FZR1	5	FZR1 [cytosol] (R-HSA-174249) FZR1 [nucleoplasm] (R-HSA-174099) p-FZR1 [nucleoplasm] (R-HSA-174257) p-FZR1 [cytosol] (R-HSA-174193) p-S151-FZR1 [nucleoplasm] (R-HSA-9929805)	0.725	6
UniProt:Q12834 CDC20	3	CDC20 [cytosol] (R-HSA-141412) CDC20 [nucleoplasm] (R-HSA-174112) PolyUb-CDC20 [nucleoplasm] (R-HSA-6783069)	0.725	5
UniProt:Q8NC69 KCTD6	1	KCTD6 [cytosol] (R-HSA-8863321)	0.718	6
UniProt:P14373 TRIM27	2	TRIM27 [cytosol] (R-HSA-8851002) TRIM27 [nucleoplasm] (R-HSA-2997690)	0.666	4
UniProt:Q13257 MAD2L1	2	MAD2L1 [cytosol] (R-HSA-141400) Activated MAD2L1 [cytosol] (R-HSA-141447)	0.643	3
UniProt:Q9JJ66	3	Cdc20 [nucleoplasm] (R-MMU-6783069) Cdc20 [nucleoplasm] (R-MMU-174112) Cdc20 [cytosol] (R-MMU-141412)	0.564	2
UniProt:P55212 CASP6	5	CASP6(194-293) [cytosol] (R-HSA-266128) CASP6(24-179) [cytosol] (R-HSA-350313) CASP6(24-179) [nucleoplasm] (R-HSA-352247) CASP6(194-293) [nucleoplasm] (R-HSA-352246) CASP6 (1-293) [cytosol] (R-HSA-6798132)	0.556	3
UniProt:Q13895 BYSL	2	BYSL [nucleoplasm] (R-HSA-6791526) BYSL [cytosol] (R-HSA-6791518)	0.556	5
UniProt:O14832 PHYH	4	PHYH [peroxisomal matrix] (R-HSA-389574) PHYH(1-338) [cytosol] (R-HSA-9033143) PHYH(1-338) [peroxisomal matrix] (R-HSA-9033535) PHYH(1-30) [peroxisomal matrix] (R-HSA-9033518)	0.556	3
UniProt:Q9Y5V3 MAGED1	1	MAGED1 [cytosol] (R-HSA-196002)	0.556	3
UniProt:P10745 RBP3	1	RBP3 [extracellular region] (R-HSA-2984190)	0.556	3
UniProt:Q9BUH8 BEGAIN	1	BEGAIN [cytosol] (R-HSA-6794250)	0.556	3
UniProt:Q53HV7 SMUG1	1	SMUG1 [nucleoplasm] (R-HSA-110161)	0.556	3
UniProt:Q8IUQ4 SIAH1	1	SIAH1 [cytosol] (R-HSA-374563)	0.556	3
UniProt:Q15742 NAB2	1	NAB2 [nucleoplasm] (R-HSA-9612177)	0.556	3
UniProt:P14136 GFAP	3	p-GFAP [lysosomal membrane] (R-HSA-9626054) GFAP [lysosomal membrane] (R-HSA-9625195) GFAP [cytosol] (R-HSA-1253311)	0.556	3
UniProt:P63000 RAC1	6	RAC1 [plasma membrane] (R-HSA-351141) RAC1 [cytosol] (R-HSA-442615) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [secretory granule membrane] (R-HSA-6804770) RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076)	0.556	3
UniProt:P51955 NEK2	1	NEK2 [cytosol] (R-HSA-177329)	0.527	2
UniProt:O43684 BUB3	1	BUB3 [cytosol] (R-HSA-141416)	0.527	2
UniProt:O75791 GRAP2	1	GRAP2 [cytosol] (R-HSA-202367)	0.527	2
UniProt:Q9UKT4 FBXO5	6	p-S182-FBXO5 [cytosol] (R-HSA-177324) p-S145,S149-FBXO5 [cytosol] (R-HSA-174207) FBXO5 [nucleoplasm] (R-HSA-174060) p-S182-FBXO5 [nucleoplasm] (R-HSA-176447) p-S145,S149-FBXO5 [nucleoplasm] (R-HSA-174220) p-FBXO5 [nucleoplasm] (R-HSA-163049)	0.527	2

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