Reactome | CDC23 [nucleoplasm]

CDC23 [nucleoplasm]

Stable Identifier

R-HSA-174228

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Apc8/Cdc23

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Diseases of mitotic cell cycle (Homo sapiens)
  - Aberrant regulation of mitotic cell cycle due to RB1 defects (Homo sapiens)
    - Aberrant regulation of mitotic exit in cancer due to RB1 defects (Homo sapiens)
      - Defective RB1 does not form a complex with SKP2 and FZR1 (Homo sapiens)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
        
        CDC23 [nucleoplasm] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by VENTX (Homo sapiens)
      - Regulation of IL6 transcription (Homo sapiens)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
        
        CDC23 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UJX2 CDC23

Gene Names

CDC23, ANAPC8

Chain

initiator methionine:1, chain:2-597

Reference Genes

BioGPS Gene:8697 CDC23

COSMIC (genes):CDC23 CDC23

CTD Gene:8697 CDC23

dbSNP Gene:8697 CDC23

ENSEMBL:ENSG00000094880 CDC23

HGNC:1724 CDC23

KEGG Gene (Homo sapiens):8697 CDC23

Monarch:8697 CDC23

NCBI Gene:8697 CDC23

OMIM:603462 CDC23

UCSC:Q9UJX2 CDC23

Reference Transcript

RefSeq:NM_004661.3 CDC23

Other Identifiers

0003870021

11721444_a_at

11752517_a_at

11757838_s_at

11759740_x_at

17000404

202892_PM_at

202892_at

223651_PM_x_at

223651_x_at

2877316

2877317

2877319

2877321

2877325

2877326

2877329

2877330

2877332

2877333

2877334

2877336

2877337

2877338

2877339

2877340

2877341

2877342

2877343

2877345

31877_at

68170_r_at

8114396

A_23_P133629

A_24_P913227

GE54494

GO:0000003

GO:0000278

GO:0003674

GO:0004842

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005680

GO:0005737

GO:0005829

GO:0006464

GO:0006511

GO:0007049

GO:0007059

GO:0007080

GO:0007091

GO:0007096

GO:0007346

GO:0008150

GO:0009056

GO:0016567

GO:0030071

GO:0031145

GO:0032991

GO:0043226

GO:0045842

GO:0051276

GO:0051301

GO:0051445

GO:0070979

GO:0140014

HMNXSV003025907

HMNXSV003049724

ILMN_1799688

PH_hs_0009232

TC05001827.hg

g13528932_3p_at

g4757947_3p_at

Participates

as a component of

Other forms of this molecule

CDC23 [cytosol]

Inferred To

CDC23 [nucleoplasm] (Bos taurus)

CDC23 [nucleoplasm] (Canis familiaris)

CDC23 [nucleoplasm] (Gallus gallus)

CDC23 [nucleoplasm] (Sus scrofa)

cut23 [nucleoplasm] (Schizosaccharomyces pombe)

Cdc23 [nucleoplasm] (Drosophila melanogaster)

Cdc23 [nucleoplasm] (Mus musculus)

Cdc23 [nucleoplasm] (Rattus norvegicus)

anapc8 [nucleoplasm] (Dictyostelium discoideum)

cdc23 [nucleoplasm] (Danio rerio)

txnip [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_004652.2

OpenTargets

ENSG00000094880

HPA

ENSG00000094880-CDC23

GeneCards

Q9UJX2

Ensembl

ENST00000394884, ENSP00000378348, ENST00000394886, ENSP00000378350, ENSG00000094880

PRO

Q9UJX2

Pharos - Targets

Q9UJX2

PDB

5L9U, 6TM5, 5A31, 5LCW, 5G04, 6Q6G, 5KHU, 5G05, 5KHR, 5L9T, 6TNT, 6TLJ, 4UI9, 6Q6H

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96CV9 OPTN	4	OPTN [recycling endosome membrane] (R-HSA-8854141) p-S177-OPTN [nucleoplasm] (R-HSA-2562595) p-S177-OPTN [cytosol] (R-HSA-2562525) OPTN [Golgi membrane] (R-HSA-2161111)	0.795	8
UniProt:Q8NC69 KCTD6	1	KCTD6 [cytosol] (R-HSA-8863321)	0.718	6
UniProt:P14373 TRIM27	2	TRIM27 [nucleoplasm] (R-HSA-2997690) TRIM27 [cytosol] (R-HSA-8851002)	0.666	4
UniProt:O60566 BUB1B	1	BUB1B [cytosol] (R-HSA-141436)	0.643	3
UniProt:Q9JJ66	3	Cdc20 [nucleoplasm] (R-MMU-6783069) Cdc20 [nucleoplasm] (R-MMU-174112) Cdc20 [cytosol] (R-MMU-141412)	0.564	2
UniProt:P63000 RAC1	6	RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [secretory granule membrane] (R-HSA-6804770) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076) RAC1 [cytosol] (R-HSA-442615) RAC1 [plasma membrane] (R-HSA-351141)	0.556	3
UniProt:P55212 CASP6	5	CASP6 (1-293) [cytosol] (R-HSA-6798132) CASP6(194-293) [nucleoplasm] (R-HSA-352246) CASP6(24-179) [nucleoplasm] (R-HSA-352247) CASP6(24-179) [cytosol] (R-HSA-350313) CASP6(194-293) [cytosol] (R-HSA-266128)	0.556	3
UniProt:Q53HV7 SMUG1	1	SMUG1 [nucleoplasm] (R-HSA-110161)	0.556	3
UniProt:P14136 GFAP	3	p-GFAP [lysosomal membrane] (R-HSA-9626054) GFAP [lysosomal membrane] (R-HSA-9625195) GFAP [cytosol] (R-HSA-1253311)	0.556	3
UniProt:Q9Y5V3 MAGED1	1	MAGED1 [cytosol] (R-HSA-196002)	0.556	3
UniProt:O14832 PHYH	4	PHYH [peroxisomal matrix] (R-HSA-389574) PHYH(1-338) [cytosol] (R-HSA-9033143) PHYH(1-338) [peroxisomal matrix] (R-HSA-9033535) PHYH(1-30) [peroxisomal matrix] (R-HSA-9033518)	0.556	3
UniProt:Q9BUH8 BEGAIN	1	BEGAIN [cytosol] (R-HSA-6794250)	0.556	3
UniProt:Q15742 NAB2	1	NAB2 [nucleoplasm] (R-HSA-9612177)	0.556	3
UniProt:Q13895 BYSL	2	BYSL [nucleoplasm] (R-HSA-6791526) BYSL [cytosol] (R-HSA-6791518)	0.556	5
UniProt:Q8IUQ4 SIAH1	1	SIAH1 [cytosol] (R-HSA-374563)	0.556	3
UniProt:P10745 RBP3	1	RBP3 [extracellular region] (R-HSA-2984190)	0.556	3
UniProt:Q12834 CDC20	3	CDC20 [cytosol] (R-HSA-141412) CDC20 [nucleoplasm] (R-HSA-174112) PolyUb-CDC20 [nucleoplasm] (R-HSA-6783069)	0.527	3

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