p-12Y-ETV6(1-154)-PDGFRB(527-1106) fusion [plasma membrane]

Stable Identifier
R-HSA-9673912
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Transcription factor ETV6, ETV6_HUMAN
Locations in the PathwayBrowser
Expand all
Literature References
PubMed ID Title Journal Year
8168137 Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation

Golub, TR, Gilliland, DG, Barker, GF, Lovett, M

Cell 1994
External Reference Information
External Reference
UniProt:P41212 ETV6
Gene Names
ETV6, TEL, TEL1
Chain
chain:1-452
Reference Genes
BioGPS Gene:2120 ETV6
COSMIC (genes):ETV6 ETV6
CTD Gene:2120 ETV6
dbSNP Gene:2120 ETV6
ENSEMBL:ENSG00000139083 ETV6
ENSEMBL_homo_sapiens_GENE:ENSG00000139083.11 ETV6
HGNC:3495 ETV6
KEGG Gene (Homo sapiens):2120 ETV6
Monarch:2120 ETV6
NCBI Gene:2120 ETV6
OMIM:600618 ETV6
UCSC:P41212 ETV6
Reference Transcript
Other Identifiers
11743165_at
11743166_at
11743167_at
1638_at
16748407
205585_PM_at
205585_at
2120
225764_PM_at
225764_at
235056_PM_at
235056_at
3405041
3405042
3405100
3405132
3405142
3405152
3405156
3405157
3405162
3405163
3405164
3405175
3405177
38491_at
55594_at
58239_at
7953981
A_14_P113857
A_23_P105264
A_24_P372862
A_33_P3210343
A_33_P3356325
GE79814
GO:0000122
GO:0000785
GO:0000977
GO:0000978
GO:0000981
GO:0001227
GO:0001228
GO:0003677
GO:0003700
GO:0005515
GO:0005634
GO:0005694
GO:0005730
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0006357
GO:0007296
GO:0012501
GO:0019904
GO:0022008
GO:0022414
GO:0030154
GO:0043226
GO:0043565
GO:0045944
GO:0048856
GO:0071425
GO:0097152
GO:0140110
GO:1990837
HMNXSV003053967
Hs.146381.2.S1_3p_at
Hs.293972.0.S1_3p_at
ILMN_1789596
PH_hs_0034188
TC12003210.hg
U11732_at
g4503610_3p_at
Participates
as a component of
Other forms of this molecule
p-11Y-ETV6(1-384)-PDGFRA(552-1089) fusion [plasma membrane]
ETV6(1-154)-PDGFRB(527-1106) fusion [plasma membrane]
ETV6(1-384)-PDGFRA(552-1089) fusion [plasma membrane]
ETV6(1-384)-FLT3(569-993) fusion [cytosol]
ETV6(1-301)-FLT3(574-993) fusion [cytosol]
ETV6(1-384)-FLT3(573-993) fusion [cytosol]
ETV6(1-336)insGCS-FLT3(573-993) fusion [cytosol]
ETV6(1-154)insGSFILG-FLT3(573-993) fusion [cytosol]
ETV6(1-384)-p-3Y-FLT3(659-1620) fusion [cytosol]
ETV6(1-301)-p-6Y-FLT3(574-993) fusion [cytosol]
ETV6(1-336)insGCS-p-6Y-FLT3(573-993) fusion [cytosol]
ETV6(1-154)insGSFILG-p-6Y-FLT3(573-993) fusion [cytosol]
ETV6(1-384)-p-6Y-FLT3(573-993) fusion [cytosol]
Modified Residues
Name
Insertion of residues 527 to 1106 at 155 from UniProt:P09619 PDGFRB
Coordinate
155
Name
O4'-phospho-L-tyrosine at 1009
Coordinate
1009
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1021
Coordinate
1021
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 579
Coordinate
579
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 581
Coordinate
581
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 716
Coordinate
716
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 740
Coordinate
740
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 751
Coordinate
751
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 763
Coordinate
763
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 771
Coordinate
771
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 775
Coordinate
775
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 778
Coordinate
778
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 857
Coordinate
857
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Disease
Name Identifier Synonyms
chronic myeloid leukemia DOID:8552 CML, chronic myelogenous leukemia, no ICD-O subtype (morphologic abnormality), chronic myeloid leukemia, disease (disorder), chronic myeloid leukemia without mention of remission, CML - chronic Myelogenous Leukemia, chronic myeloid leukemia in remission (disorder), Myeloid Leukemia, chronic, CML in Remission, chronic myeloid leukemia in remission, chronic myeloid leukaemia, chronic myeloid leukemia NOS (disorder)
Cross References
RefSeq
ZINC - World Drugs
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC target
PRO
PDB
GeneCards
HPA
Ensembl
Pharos - Targets
ZINC - Predictions - Purchasable
Orphanet
Interactors (5)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q13114 TRAF3  4 0.671 5
 UniProt:Q13526 PIN1  2 0.666 4
 UniProt:O75581 LRP6  8 0.643 3
 UniProt:Q16236 NFE2L2  13 0.625 5
 UniProt:O75197 LRP5  5 0.527 3
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