ETV6(1-384)-FLT3(569-993) fusion [cytosol]

Stable Identifier
R-HSA-9697944
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Transcription factor ETV6, ETV6_HUMAN
Locations in the PathwayBrowser
Expand all
Literature References
PubMed ID Title Journal Year
23168613 Direct binding of Grb2 has an important role in the development of myeloproliferative disease induced by ETV6/FLT3

Chonabayashi, K, Hishizawa, M, Kawamata, S, Nagai, Y, Ohno, T, Ishikawa, T, Uchiyama, T, Takaori-Kondo, A

Leukemia 2013
External Reference Information
External Reference
UniProt:P41212 ETV6
Gene Names
ETV6, TEL, TEL1
Chain
chain:1-452
Reference Genes
BioGPS Gene:2120 ETV6
COSMIC (genes):ETV6 ETV6
CTD Gene:2120 ETV6
dbSNP Gene:2120 ETV6
ENSEMBL:ENSG00000139083 ETV6
HGNC:3495 ETV6
KEGG Gene (Homo sapiens):2120 ETV6
Monarch:2120 ETV6
NCBI Gene:2120 ETV6
OMIM:600618 ETV6
UCSC:P41212 ETV6
Reference Transcript
Other Identifiers
0004050433
11743165_at
11743166_at
11743167_at
1638_at
16748407
205585_at
2120
225764_at
235056_at
3405041
3405042
3405100
3405132
3405142
3405152
3405156
3405157
3405162
3405163
3405164
3405175
3405177
38491_at
55594_at
58239_at
7953981
A_14_P113857
A_23_P105264
A_24_P372862
A_33_P3210343
A_33_P3356325
GE79814
GO:0000003
GO:0000122
GO:0000228
GO:0000790
GO:0000977
GO:0000978
GO:0000981
GO:0001227
GO:0001228
GO:0002376
GO:0003674
GO:0003677
GO:0003700
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005694
GO:0005730
GO:0005737
GO:0005829
GO:0006355
GO:0006357
GO:0007296
GO:0008150
GO:0008219
GO:0008283
GO:0009058
GO:0019904
GO:0022008
GO:0030154
GO:0034641
GO:0042025
GO:0043226
GO:0043565
GO:0045944
GO:0048856
GO:0071425
GO:0097152
Hs.146381.2.S1_3p_at
Hs.293972.0.S1_3p_at
ILMN_1789596
PH_hs_0034188
TC12003210.hg
U11732_at
g4503610_3p_at
Participant Of
hasMember
hasComponent
Other forms of this molecule
ETV6(1-301)-FLT3(574-993) fusion [cytosol]
ETV6(1-384)-PDGFRA(552-1089) fusion [plasma membrane]
ETV6(1-154)-PDGFRB(527-1106) fusion [plasma membrane]
p-11Y ETV6(1-384)-PDGFRA(552-1089) fusion [plasma membrane]
p-12Y ETV6(1-154)-PDGFRB(527-1106) fusion [plasma membrane]
ETV6(1-384)-p-6Y FLT3(573-993) fusion [cytosol]
ETV6(1-154insGSFILG)-p-6Y FLT3(573-993) fusion [cytosol]
ETV6(1-338insGCS)-p-6Y FLT3(573-993) fusion [cytosol]
ETV6(1-301)-p-6Y FLT3(574-993) fusion [cytosol]
ETV6(1-384)-p-3Y FLT3(659-1620) fusion [cytosol]
ETV6(1-154insGSFILG)-FLT3(573-993) fusion [cytosol]
ETV6(1-338insGCS)-FLT3(573-993) fusion [cytosol]
ETV6(1-384)-FLT3(573-993) fusion [cytosol]
Modified Residues
Name
Insertion of residues 569 to 993 at 385 from UniProt:P36888 FLT3
Coordinate
385
Disease
Name Identifier Synonyms
myeloproliferative neoplasm 2226 CMPD, chronic myeloproliferative disease, CMPD, U
Cross References
RefSeq
ZINC - World Drugs
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC target
PRO
PDB
HPA
GeneCards
Ensembl
Orphanet
ZINC - Predictions - Purchasable
Interactors (1)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q13526 PIN1  2 0.556 3
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