Reactome | CDC16 [nucleoplasm]

CDC16 [nucleoplasm]

Stable Identifier

R-HSA-174049

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Apc6/Cdc16

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Diseases of mitotic cell cycle (Homo sapiens)
  - Aberrant regulation of mitotic cell cycle due to RB1 defects (Homo sapiens)
    - Aberrant regulation of mitotic exit in cancer due to RB1 defects (Homo sapiens)
      - Defective RB1 does not form a complex with SKP2 and FZR1 (Homo sapiens)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
        
        CDC16 [nucleoplasm] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by VENTX (Homo sapiens)
      - Regulation of IL6 transcription (Homo sapiens)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
        
        CDC16 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13042 CDC16

Gene Names

CDC16, ANAPC6

Chain

chain:1-620

Reference Genes

BioGPS Gene:8881 CDC16

COSMIC (genes):CDC16 CDC16

CTD Gene:8881 CDC16

dbSNP Gene:8881 CDC16

ENSEMBL:ENSG00000130177 CDC16

HGNC:1720 CDC16

KEGG Gene (Homo sapiens):8881 CDC16

Monarch:8881 CDC16

NCBI Gene:8881 CDC16

OMIM:603461 CDC16

UCSC:Q13042 CDC16

Reference Transcript

Other Identifiers

11716809_a_at

11719625_a_at

11746106_a_at

11746107_a_at

11754804_x_at

16776989

202717_s_at

209658_at

209659_s_at

3503165

3503166

3503167

3503168

3503173

3503175

3503176

3503177

3503178

3503180

3503181

3503183

3503185

3503187

3503188

3503190

3503193

3503195

3503197

3503199

3503205

3503207

3503208

3503209

3503210

3503211

40404_s_at

7970347

8881

A_33_P3392325

GE58978

GO:0000278

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005680

GO:0005737

GO:0005813

GO:0005815

GO:0005819

GO:0005829

GO:0005856

GO:0006464

GO:0006511

GO:0007049

GO:0007059

GO:0007091

GO:0008150

GO:0009056

GO:0016567

GO:0031145

GO:0032991

GO:0043226

GO:0045842

GO:0051276

GO:0051301

GO:0070979

GO:0072686

GO:0140014

GO:1901990

HMNXSV003003296

HMNXSV003007455

ILMN_2256765

ILMN_2339796

PH_hs_0000215

TC13000435.hg

U18291_at

g4502700_3p_a_at

Participates

as a component of

Other forms of this molecule

CDC16 [cytosol]

Inferred To

cdc16 [nucleoplasm] (Danio rerio)

Cdc16 [nucleoplasm] (Drosophila melanogaster)

Cdc16 [nucleoplasm] (Mus musculus)

Cdc16 [nucleoplasm] (Rattus norvegicus)

anapc6 [nucleoplasm] (Dictyostelium discoideum)

CDC16 [nucleoplasm] (Canis familiaris)

CDC16 [nucleoplasm] (Gallus gallus)

CDC16 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_001317033.1, NP_001317030.1, NP_001072113.1, NP_001305447.1, NP_003894.3, NP_001305446.1, NP_001317034.1, XP_016876322.1

OpenTargets

ENSG00000130177

HPA

ENSG00000130177-CDC16

GeneCards

Q13042

Ensembl

ENST00000252457, ENST00000360383, ENSP00000348554, ENSP00000364457, ENST00000356221, ENST00000375310, ENSP00000353549, ENSP00000252457, ENST00000375308, ENSP00000364459, ENSG00000130177

PRO

Q13042

PDB

5LCW, 3HYM, 5G04, 6TM5, 5KHR, 5L9T, 5G05, 6Q6G, 6Q6H, 5L9U, 5A31, 5KHU, 4UI9, 6TLJ

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12834 CDC20	3	CDC20 [nucleoplasm] (R-HSA-174112) CDC20 [cytosol] (R-HSA-141412) PolyUb-CDC20 [nucleoplasm] (R-HSA-6783069)	0.623	4
UniProt:Q9JJ66	3	Cdc20 [nucleoplasm] (R-MMU-174112) Cdc20 [nucleoplasm] (R-MMU-6783069) Cdc20 [cytosol] (R-MMU-141412)	0.564	2
UniProt:P51955 NEK2	1	NEK2 [cytosol] (R-HSA-177329)	0.527	2
UniProt:O60566 BUB1B	1	BUB1B [cytosol] (R-HSA-141436)	0.527	2

Cite Us!