Reactome | CDC16 [nucleoplasm]

CDC16 [nucleoplasm]

Stable Identifier

R-HSA-174049

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Apc6/Cdc16

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Diseases of mitotic cell cycle (Homo sapiens)
  - Aberrant regulation of mitotic cell cycle due to RB1 defects (Homo sapiens)
    - Aberrant regulation of mitotic exit in cancer due to RB1 defects (Homo sapiens)
      - Defective RB1 does not form a complex with SKP2 and FZR1 (Homo sapiens)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
        
        CDC16 [nucleoplasm] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by VENTX (Homo sapiens)
      - Regulation of IL6 transcription (Homo sapiens)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
        
        CDC16 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13042 CDC16

Gene Names

CDC16, ANAPC6

Chain

chain:1-620

Reference Genes

BioGPS Gene:8881 CDC16

COSMIC (genes):CDC16 CDC16

CTD Gene:8881 CDC16

dbSNP Gene:8881 CDC16

ENSEMBL:ENSG00000130177 CDC16

HGNC:1720 CDC16

KEGG Gene (Homo sapiens):8881 CDC16

Monarch:8881 CDC16

NCBI Gene:8881 CDC16

OMIM:603461 CDC16

UCSC:Q13042 CDC16

Reference Transcript

Other Identifiers

11716809_a_at

11719625_a_at

11746106_a_at

11746107_a_at

11754804_x_at

16776989

202717_PM_s_at

202717_s_at

209658_PM_at

209658_at

209659_PM_s_at

209659_s_at

3503165

3503166

3503167

3503168

3503173

3503175

3503176

3503177

3503178

3503180

3503181

3503183

3503185

3503187

3503188

3503190

3503193

3503195

3503197

3503199

3503205

3503207

3503208

3503209

3503210

3503211

40404_s_at

7970347

8881

A_33_P3392325

GE58978

GO:0000003

GO:0000278

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005680

GO:0005737

GO:0005813

GO:0005815

GO:0005819

GO:0005829

GO:0005856

GO:0006464

GO:0007049

GO:0007059

GO:0007091

GO:0007346

GO:0008150

GO:0009056

GO:0016567

GO:0031145

GO:0032991

GO:0043226

GO:0045842

GO:0051276

GO:0051301

GO:0051445

GO:0070979

GO:0072686

GO:0140014

HMNXSV003003296

HMNXSV003007455

ILMN_2256765

ILMN_2339796

PH_hs_0000215

TC13000435.hg

U18291_at

g4502700_3p_a_at

Participates

as a component of

Other forms of this molecule

CDC16 [cytosol]

Inferred To

cdc16 [nucleoplasm] (Danio rerio)

cdc16 [nucleoplasm] (Xenopus tropicalis)

Cdc16 [nucleoplasm] (Drosophila melanogaster)

Cdc16 [nucleoplasm] (Mus musculus)

Cdc16 [nucleoplasm] (Rattus norvegicus)

anapc6 [nucleoplasm] (Dictyostelium discoideum)

CDC16 [nucleoplasm] (Bos taurus)

CDC16 [nucleoplasm] (Canis familiaris)

CDC16 [nucleoplasm] (Gallus gallus)

CDC16 [nucleoplasm] (Sus scrofa)

cut9 [nucleoplasm] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_001317033.1, NP_001305447.1, NP_001317034.1, XP_016876322.1, NP_001317030.1, NP_001305446.1, NP_003894.3, NP_001072113.1

OpenTargets

ENSG00000130177

HPA

ENSG00000130177-CDC16

GeneCards

Q13042

Ensembl

ENST00000356221, ENSP00000364457, ENSP00000252457, ENST00000252457, ENST00000375308, ENST00000360383, ENSP00000364459, ENST00000375310, ENSP00000353549, ENSP00000348554, ENSG00000130177

PRO

Q13042

Pharos - Targets

Q13042

PDB

6Q6G, 5KHU, 5LCW, 3HYM, 5G04, 6TLJ, 5L9U, 5KHR, 5L9T, 4UI9, 6TM5, 6TNT, 5G05, 6Q6H, 5A31

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O60566 BUB1B	1	BUB1B [cytosol] (R-HSA-141436)	0.643	3
UniProt:Q12834 CDC20	3	CDC20 [cytosol] (R-HSA-141412) CDC20 [nucleoplasm] (R-HSA-174112) PolyUb-CDC20 [nucleoplasm] (R-HSA-6783069)	0.623	4
UniProt:Q9JJ66	3	Cdc20 [nucleoplasm] (R-MMU-6783069) Cdc20 [nucleoplasm] (R-MMU-174112) Cdc20 [cytosol] (R-MMU-141412)	0.564	2
UniProt:P51955 NEK2	1	NEK2 [cytosol] (R-HSA-177329)	0.527	2

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