Reactome | Dengue virus type 2

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Dengue virus type 2 Show undefined attributes

abbreviation	DVI
created	[InstanceEdit:3244632] Shamovsky, V, 2013-03-28
crossReference	[DatabaseIdentifier:5617201] NCBI Taxonomy:11060
dbId	3244621
displayName	Dengue virus type 2
modified	[InstanceEdit:9014479] Weiser, JD
name	Dengue virus type 2
schemaClass	Species
superTaxon	[Taxon:8949984] Dengue virus
taxId	11060

Referrals

(relatedSpecies)

[Pathway:R-HSA-9839923] Dengue Virus Infection
[Pathway:R-HSA-9918487] Dengue Virus Genome Translation and Replication
[Pathway:R-HSA-9918485] Dengue Virus Attachment and Entry
[BlackBoxEvent:R-HSA-9945936] Dengue virion:HAVCR1 induces autophagosome formation
[Complex:R-HSA-9945920] DENV-2 virion:HAVCR1 [autophagosome membrane]
[Reaction:R-HSA-9956864] DENV virion binds E ligands
[Pathway:R-HSA-9918432] Maturation of DENV proteins
[Pathway:R-HSA-9918476] Assembly and Release of Dengue Virus Virions
[BlackBoxEvent:R-HSA-9923824] Mature virion is released
[Reaction:R-HSA-9946670] PE binds to mature Dengue virion
[Reaction:R-HSA-9919050] Furin cleaves prM:E
[BlackBoxEvent:R-HSA-9923837] Immature virion localizes to exocytic vesicle
[BlackBoxEvent:R-HSA-9923828] Immature virion localizes to Golgi lumen
[BlackBoxEvent:R-HSA-9923836] DENV virion buds into ER lumen
[Reaction:R-HSA-9920258] prM:E forms head-to-tail dimers
[BlackBoxEvent:R-HSA-9920243] Protein C coats dengue genomic +ssRNA
[BlackBoxEvent:R-HSA-9954394] C dimer localizes to lipid droplets
[Pathway:R-HSA-9918481] Dengue Virus-Host Interactions
[Reaction:R-HSA-9948266] NS3 binds PDCD6IP
[Complex:R-HSA-9948269] NS3:PDCD6IP [cytosol]
[Reaction:R-HSA-9947629] NS1 binds HNRNPH1
[Complex:R-HSA-9947626] NS1:HNRNPH1 [cytosol]
[Reaction:R-HSA-9921517] NS1 binds NEK2
[Complex:R-HSA-9921506] NS1:NEK2 [cytosol]
[Reaction:R-HSA-9921198] NS1 binds MMP9 and CTNNB1
[Complex:R-HSA-9921221] NS1:MMP9:CTNNB1 [plasma membrane]
[Reaction:R-HSA-9921263] NS3 binds NRBP1
[Complex:R-HSA-9921247] NS3:NRBP1 [endoplasmic reticulum membrane]
[Reaction:R-HSA-9921250] C binds HNRNPK
[Complex:R-HSA-9921251] C:HNRNPK [nucleoplasm]
[Reaction:R-HSA-9947747] NS5 binds GBF1
[Complex:R-HSA-9947741] NS5:GBF1 [cytosol]
[Reaction:R-HSA-9921507] NS5 interacts with Spliceosome
[Complex:R-HSA-9921511] NS5:Spliceosomal Intermediate C Complex [nucleoplasm]
[Reaction:R-HSA-9921200] Secreted NS1 binds 10xCbxE-F2(44-622)
[Complex:R-HSA-9921219] NS1:10xCBxE-F2 [extracellular region]
[Reaction:R-HSA-9921264] NS5 binds TJP1
[Complex:R-HSA-9921235] NS5:TJP1 [nucleoplasm]
[Reaction:R-HSA-9921458] NS1 binds TLR4
[Complex:R-HSA-9921476] TLR4:LY96:NS1 [plasma membrane]
[Reaction:R-HSA-9921202] NS1 binds MMP9 and TJP1
[Complex:R-HSA-9921220] NS1:MMP9:TJP1 [cell junction]
[Reaction:R-HSA-9948087] CAMK2 complex phosphorylates VIM:NS4A
[Reaction:R-HSA-9921527] NS1 binds COG1
[Complex:R-HSA-9921503] NS1:COG1 [endoplasmic reticulum-Golgi intermediate compartment membrane]
[Pathway:R-HSA-9920951] Dengue virus modulates apoptosis
[Reaction:R-HSA-9921160] NS2B3 binds NFKBIB
[Complex:R-HSA-9921161] NS2B3:NFKBIB [cytosol]
[Reaction:R-HSA-9921289] NS5 binds DAXX
[Complex:R-HSA-9921303] NS5:DAXX [nucleoplasm]
[Reaction:R-HSA-9947739] NS5 binds mTORC1,2
[Complex:R-HSA-9947744] NS5:mTORC1,2 [cytosol]
[Reaction:R-HSA-9921595] NS2B3 cleaves FAM134B
[Reaction:R-HSA-9921168] NS2B3 binds NFKBIA
[Complex:R-HSA-9921158] NS2B3:NFKBIA [cytosol]
[Reaction:R-HSA-9921857] NS3 binds RIPK1
[Complex:R-HSA-9921861] NS3:RIPK1 [endoplasmic reticulum membrane]
[Reaction:R-HSA-9920945] C binds DAXX
[Complex:R-HSA-9920947] C:DAXX [nucleoplasm]
[Reaction:R-HSA-9921171] NS1 binds Beclin-1
[Complex:R-HSA-9921153] NS1:Beclin-1 [endoplasmic reticulum membrane]
[Reaction:R-HSA-9921526] NS1 binds TAO1
[Complex:R-HSA-9921523] NS1:TAOK1 [cytosol]
[Reaction:R-HSA-9921290] C binds histones
[Complex:R-HSA-9921294] C:Histones [nucleoplasm]
[Reaction:R-HSA-9948108] NS4A binds VIM
[Complex:R-HSA-9948088] NS4A:VIM [endoplasmic reticulum membrane]
[Pathway:R-HSA-9920588] Dengue virus activates/modulates innate and adaptive immune responses
[Reaction:R-HSA-9921544] NS1 binds MBL
[Complex:R-HSA-9921542] NS1:HDL:MBL [extracellular region]
[BlackBoxEvent:R-HSA-9920843] C binds TRIM25
[Complex:R-HSA-9920869] C:TRIM25 [cytosol]
[Reaction:R-HSA-9920878] NS5 binds STAT2
[Complex:R-HSA-9920867] NS5:STAT2 [endoplasmic reticulum membrane]
[Reaction:R-HSA-9920623] NS1 binds C4BP
[Complex:R-HSA-9920626] NS1:C4BP [plasma membrane]
[Reaction:R-HSA-9921600] C binds DDX3X
[Complex:R-HSA-9921598] C:DDX3X [nucleoplasm]
[Reaction:R-HSA-9921217] NS1 binds CLU
[Complex:R-HSA-9921213] NS1:HDL:CLU [extracellular region]
[Reaction:R-HSA-9920772] prM binds IFIH1
[Complex:R-HSA-9920775] prM:IFIH1 [endoplasmic reticulum-Golgi intermediate compartment membrane]
[Reaction:R-HSA-9921319] C binds EXOC1
[Complex:R-HSA-9921310] C:EXOC1 [cytosol]
[Reaction:R-HSA-9920952] NS2B3 binds IKBKE
[Complex:R-HSA-9920946] NS2B3:IKBKE [cytosol]
[Reaction:R-HSA-9921721] NS5 binds RBM10
[Complex:R-HSA-9921719] NS5:RBM10 [nucleoplasm]
[Reaction:R-HSA-9920793] NS4A binds MAVS
[Complex:R-HSA-9920774] NS4A:MAVS [mitochondrial outer membrane]
[Reaction:R-HSA-9947771] Dengue virion binds CLEC5A
[Complex:R-HSA-9947764] DENV-2 virion:CLEC5A [plasma membrane]
[Reaction:R-HSA-9920796] NS1 binds VTN
[Complex:R-HSA-9920784] NS1:HDL:VTN [extracellular region]
[Reaction:R-HSA-9920957] NS5 binds UBR4
[Complex:R-HSA-9920932] NS5:UBR4 [endoplasmic reticulum membrane]
[Reaction:R-HSA-9921693] NS5 binds PML-3/4
[Complex:R-HSA-9921708] NS5:PML-3/4 [nucleoplasm]
[Reaction:R-HSA-9920829] NS5 binds HSP90
[Complex:R-HSA-9920816] NS5:HSP90 [endoplasmic reticulum membrane]
[Reaction:R-HSA-9920638] NS1 binds C1QA
[Complex:R-HSA-9920632] NS1:HDL:C1QA [extracellular region]
[Reaction:R-HSA-9920882] NS2B binds CGAS
[Complex:R-HSA-9920820] NS2B:CGAS [cytosol]
[BlackBoxEvent:R-HSA-3244626] DENV protease NS2B3 cleaves STING
[Reaction:R-HSA-3244618] DENV protease NS2B3 binds STING
[Complex:R-HSA-3244608] NS2B3:STING [endoplasmic reticulum membrane]
[Reaction:R-HSA-9920628] NS1 binds C4A/B and C1S
[Complex:R-HSA-9920629] NS1:HDL:C4:C1S [extracellular region]
[Reaction:R-HSA-9921879] NS5 binds PAF1C
[Complex:R-HSA-9921884] NS5:PAF1C [nucleoplasm]
[Reaction:R-HSA-9946935] DENV sfRNA binds TRIM25
[Complex:R-HSA-9946939] DENV sfRNA:TRIM25 [cytosol]
[Reaction:R-HSA-9921869] C binds PEX19
[Complex:R-HSA-9921885] C:PEX19 [cytosol]
[Reaction:R-HSA-9921605] NS4A binds AUP1
[Complex:R-HSA-9921601] NS4A:AUP1 [endoplasmic reticulum membrane]
[Reaction:R-HSA-9921689] NS3 cleaves GrpEL1
[Reaction:R-HSA-9921306] NS1 binds RPL18
[Complex:R-HSA-9921315] NS1:RPL18 [cytosol]
[Reaction:R-HSA-9921883] E binds TAL1
[Complex:R-HSA-9921895] E:TAL1 [endoplasmic reticulum membrane]
[Reaction:R-HSA-9922140] NS3 binds HSPA8
[Complex:R-HSA-9922172] NS3:HSPA8 [endoplasmic reticulum membrane]
[Reaction:R-HSA-9921245] E binds UBE2I
[Complex:R-HSA-9921261] E:UBE2I [nuclear envelope]
[BlackBoxEvent:R-HSA-9921695] NS1 gets endocytosed
[Reaction:R-HSA-9921297] prM binds DYNLT1
[Complex:R-HSA-9921320] prM:DYNLT1 [endoplasmic reticulum membrane]
[BlackBoxEvent:R-HSA-9920147] Secreted NS1 binds to other cell
[Reaction:R-HSA-9948053] NS3 binds FASN dimer
[BlackBoxEvent:R-HSA-9945387] NS2B3 localizes to nucleus
[Reaction:R-HSA-9954667] NS2B3 binds Dengue protease inhibitors
[Reaction:R-HSA-9956857] Domperidone binds NS1
[BlackBoxEvent:R-HSA-9920575] NS3 localizes to the mitochondrial matrix
[BlackBoxEvent:R-HSA-9921591] Soluble NS1 forms a hexamer (cytosol)
[Reaction:R-HSA-9947535] NS1 dimer associates with exosomes
[BlackBoxEvent:R-HSA-9920071] Secreted NS1 binds to HDL
[Reaction:R-HSA-9920051] NS1 dimer localizes to the cell membrane
[Complex:R-HSA-9919955] NS1:HDL [extracellular region]
[BlackBoxEvent:R-HSA-9919047] prM binds E
[BlackBoxEvent:R-HSA-9918988] pre-M is N-glycosylated
[BlackBoxEvent:R-HSA-9919009] NMT1 interacts with E
[BlackBoxEvent:R-HSA-9918962] E is N-glycosylated
[BlackBoxEvent:R-HSA-9945309] NS3 localizes to ER membrane
[BlackBoxEvent:R-HSA-9945325] NS3 localizes to nucleus
[BlackBoxEvent:R-HSA-9945181] C dimer gets exported from nucleus
[BlackBoxEvent:R-HSA-9919944] C dimer localizes to nucleus
[Reaction:R-HSA-9922227] C forms a dimer
[Reaction:R-HSA-9918876] NS2B3 cleaves prepro-C at the C-prM junction
[Reaction:R-HSA-9947672] YBX1 binds DENV mRNA
[Reaction:R-MMU-9947669] Ybx1 binds DENV genomic RNA
[Complex:R-MMU-9947681] Ybx1:DENV mRNA [cytosol]
[Reaction:R-HSA-9948218] HDLBP and RRBP1 bind DENV mRNA
[BlackBoxEvent:R-HSA-9946390] NS1 dimer is ubiquitinated
[Reaction:R-HSA-9920215] NS5 binds NS3
[BlackBoxEvent:R-HSA-9920046] NS5 is exported from nucleus
[BlackBoxEvent:R-HSA-9920126] UBC9 SUMOylates NS5
[BlackBoxEvent:R-HSA-9919966] NS5 localizes to nucleus
[Reaction:R-HSA-9919982] NS5 is glutathionylated
[Reaction:R-HSA-9920025] PKG phosphorylates NS5
[Reaction:R-BTA-9954423] PKG phosphorylates NS5
[Reaction:R-HSA-9918823] NS345:NS2B cleaves NS345
[Reaction:R-HSA-9918772] Dengue polyprotein cis-auto-cleaves
[BlackBoxEvent:R-HSA-9918810] HyPro-polyprotein folds
[Reaction:R-HSA-9918779] Proline hydroxylases hydroxylate Polyprotein
[BlackBoxEvent:R-HSA-9923067] Nascent polyprotein starts folding in ER
[BlackBoxEvent:R-HSA-9947293] IRES-mediated translation of DENV genomic RNA
[BlackBoxEvent:R-HSA-9947230] Cap-dependent translation of DENV genomic RNA
[BlackBoxEvent:R-HSA-9947465] Import of DENV RNA from exosomes
[BlackBoxEvent:R-HSA-9947387] Exosomal secretion of DENV RNA and proteins
[BlackBoxEvent:R-HSA-9946917] XRN1 incompletely hydrolyzes DENV decapped mRNA
[BlackBoxEvent:R-HSA-9946784] DENV mRNA is decapped
[Reaction:R-HSA-9923094] DENV capped genome (+)-RNA dissociates from RC
[Reaction:R-HSA-9923097] NS5 acts as a cap 2'-O-methyltransferase to methylate 5? m7GpppA of DENV genomic +ssRNA
[BlackBoxEvent:R-HSA-9923104] NS5 acts as a cap N7 methyltransferase to methylate 5? G pppA of DENV genomic +ssRNA
[BlackBoxEvent:R-HSA-9923071] NS5 transfers guanylyl onto DENV genomic 5'-ppRNA
[Reaction:R-HSA-9923980] NS3 cleaves triphosphate moiety of genomic +ssRNA
[BlackBoxEvent:R-HSA-9923068] NS5 synthesizes plus strand genome
[BlackBoxEvent:R-HSA-9923074] Circularization of (-)-genomic RNA
[BlackBoxEvent:R-HSA-9923073] NS3 unwinds dsRNA secondary structures
[BlackBoxEvent:R-HSA-9922955] NS5 synthesizes minus strand genome
[BlackBoxEvent:R-HSA-9922965] Circularization of (+)-genomic RNA
[BlackBoxEvent:R-HSA-9922957] NS3 melts (+)-RNA secondary structures
[Reaction:R-HSA-9922961] DENV genomic RNA binds Replication Complex
[BlackBoxEvent:R-HSA-9922491] Dengue virion releases its genome
[BlackBoxEvent:R-HSA-9947662] PS moves from ER to lysosome
[BlackBoxEvent:R-HSA-9922480] Dengue virion gets internalized
[Reaction:R-HSA-9918494] Dengue virion envelope phosphatidylserine binds TIM receptor
[Reaction:R-HSA-9918496] Dengue virion envelope phosphatidylserine binds liganded TAM-family receptor
[Reaction:R-HSA-9946309] Dengue virion M protein binds CLDN1 on hepatic cells
[Reaction:R-HSA-9918501] Dengue virion E protein binds CD209 on dendritic cells
[DefinedSet:R-HSA-9922608] DENV-2 virion:Receptor [plasma membrane]
[Complex:R-HSA-9922463] DENV-2 virion:HAVCR1 [plasma membrane]
[Complex:R-HSA-9922385] DENV-2 virion:Unknown receptor [plasma membrane]
[Complex:R-HSA-9922289] DENV-2 virion:CD209 [plasma membrane]
[Complex:R-HSA-9922466] DENV-2 virion:TAM receptor ligands:TAM receptor [plasma membrane]
[Complex:R-HSA-9946306] DENV-2 virion:CLDN1 [plasma membrane]
[DefinedSet:R-HSA-9922614] DENV-2 virion:Receptor [endosome membrane]
[Complex:R-HSA-9922618] DENV-2 virion:TAM receptors:TAM receptor ligands [endosome membrane]
[Complex:R-HSA-9946316] DENV-2 virion:CLDN1 [endosome membrane]
[Complex:R-HSA-9922606] DENV-2 virion:HAVCR1 [endosome membrane]
[Complex:R-HSA-9922623] DENV-2 virion:CD209 [endosome membrane]
[Complex:R-HSA-9922611] DENV-2 virion:Unknown receptor [endosome membrane]
[BlackBoxEvent:R-HSA-9920087] Nonstructural proteins form the replication complex
[Reaction:R-HSA-9919979] NS1 dimerizes and assembles into lipoprotein particles
[BlackBoxEvent:R-HSA-9919011] Pre-NS1 folds and is N-glycosylated
[Reaction:R-HSA-9918780] Unknown peptidase cleaves NS1-NS2A
[BlackBoxEvent:R-HSA-9918795] Signalase cleaves prM-E-NS1-NS2A
[BlackBoxEvent:R-HSA-9918787] NS2B3 cleaves C-prM-E-NS1-NS2A
[Reaction:R-HSA-9924274] NS4B forms a dimer
[Reaction:R-HSA-9918871] Signalase cleaves prepro-NS4B
[Reaction:R-HSA-9918813] NS2B3 cleaves NS4AB
[Reaction:R-HSA-9918807] NS2B binds NS3
[BlackBoxEvent:R-HSA-9945766] NS3 is ubiquitinated
[Reaction:R-HSA-9947496] ACOT2 cleaves NS345
[Reaction:R-HSA-9918798] NS2B binds to NS345
[Reaction:R-HSA-9918817] NS2B3 cleaves polyprotein
[Complex:R-HSA-9948038] NS3:FASN [cytosol]
[Complex:R-HSA-9947674] YBX1:DENV mRNA [cytosol]
[Complex:R-HSA-9948237] HDBLP:RRBP1:DENV mRNA [endoplasmic reticulum membrane]
[Complex:R-HSA-9948078] NS4A:p39-VIM [endoplasmic reticulum membrane]

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