Reactome | NS1 binds TLR4

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NS1 binds TLR4 Show undefined attributes

authored	[InstanceEdit:9921340] Stephan, Ralf, 2024-09-09
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9921459] Stephan, Ralf, 2024-09-10
crossReference	[DatabaseIdentifier:12020825] Mondo:0005502
dbId	9921458
disease	[Disease:3244610] dengue disease
displayName	NS1 binds TLR4
edited	[InstanceEdit:9970471] Stephan, Ralf, 2025-10-30
eventOf	[Pathway:R-HSA-9918481] Dengue Virus-Host Interactions - Homo sapiens
input	[Complex:R-DVI-9920090] NS1 hexamer lipoparticle [plasma membrane] [Complex:R-HSA-166050] TLR4:LY96 [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9921480] Dengue virus NS1 protein activates cells via Toll-like receptor 4 and disrupts endothelial cell monolayer integrity [LiteratureReference:9921478] Dengue virus NS1 protein activates immune cells via TLR4 but not TLR2 or TLR6 [LiteratureReference:9921462] Dengue virus nonstructural protein 1 activates platelets via Toll-like receptor 4, leading to thrombocytopenia and hemorrhage
maxDepth	1
modified	[InstanceEdit:9970472] Stephan, Ralf, 2025-10-30
name	NS1 binds TLR4
output	[Complex:R-HSA-9921476] TLR4:LY96:NS1 [plasma membrane]
precedingEvent	[BlackBoxEvent:R-HSA-9920147] Secreted NS1 binds to other cell - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
relatedSpecies	[Species:3244621] Dengue virus type 2
releaseDate	2025-12-08
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9970439] Roque Ascen��o, Fernando, 2025-10-29 [InstanceEdit:9970204] Mansur, Daniel Santos, 2025-10-29
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9921458
summation	[Summation:9921465] Secreted Dengue virus (DENV) NS1 protein, primarily from DEN...

Referrals

(hasEvent)

[Pathway:R-HSA-9918481] Dengue Virus-Host Interactions

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