Reactome | PKG phosphorylates NS5

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PKG phosphorylates NS5 Show undefined attributes

authored	[InstanceEdit:9919049] Stephan, Ralf, 2024-08-19
catalystActivity	[CatalystActivity:9920145] cGMP-dependent protein kinase activity of Activated cGMP-dependent protein kinase (PKGs) [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9920038] Stephan, Ralf, 2024-08-29
crossReference	[DatabaseIdentifier:12020825] Mondo:0005502 [DatabaseIdentifier:9857129] RHEA:46609
dbId	9920025
disease	[Disease:3244610] dengue disease
displayName	PKG phosphorylates NS5
edited	[InstanceEdit:9966335] Stephan, Ralf, 2025-09-18
eventOf	[Pathway:R-HSA-9918432] Maturation of DENV proteins - Homo sapiens
followingEvent	[Reaction:R-HSA-9919982] NS5 is glutathionylated - Homo sapiens
inferredFrom	[Reaction:R-BTA-9954423] PKG phosphorylates NS5 - Bos taurus
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-DVI-9918834] pre-NS5 [endoplasmic reticulum membrane]
isChimeric	false
isInDisease	true
isInferred	true
literatureReference	[LiteratureReference:9920119] Protein kinase G phosphorylates mosquito-borne flavivirus NS5 [LiteratureReference:9920023] Association between NS3 and NS5 proteins of dengue virus type 2 in the putative RNA replicase is linked to differential phosphorylation of NS5
maxDepth	1
modified	[InstanceEdit:9970472] Stephan, Ralf, 2025-10-30
name	PKG phosphorylates NS5
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [EntityWithAccessionedSequence:R-DVI-9919971] p-NS5 [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-HSA-9918823] NS345:NS2B cleaves NS345 - Homo sapiens [Reaction:R-HSA-9947496] ACOT2 cleaves NS345 - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
relatedSpecies	[Species:3244621] Dengue virus type 2
releaseDate	2025-12-08
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9966332] Mansur, Daniel Santos, 2025-09-18 [InstanceEdit:9970439] Roque Ascen��o, Fernando, 2025-10-29
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9920025
summation	[Summation:9954418] NS5 from DENV-2 (strain U87411) is phosphorylated at Thr-449...

Referrals

(hasEvent)	[Pathway:R-HSA-9918432] Maturation of DENV proteins
(precedingEvent)	[Reaction:R-HSA-9919982] NS5 is glutathionylated
(inferredTo)	[Reaction:R-BTA-9954423] PKG phosphorylates NS5

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