Reactome | C dimer localizes to nucleus

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C dimer localizes to nucleus Show undefined attributes

authored	[InstanceEdit:9919049] Stephan, Ralf, 2024-08-19
category	uncertain
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:9920038] Stephan, Ralf, 2024-08-29
crossReference	[DatabaseIdentifier:12020825] Mondo:0005502
dbId	9919944
disease	[Disease:3244610] dengue disease
displayName	C dimer localizes to nucleus
edited	[InstanceEdit:9966335] Stephan, Ralf, 2025-09-18
eventOf	[Pathway:R-HSA-9918432] Maturation of DENV proteins - Homo sapiens
followingEvent	[Reaction:R-HSA-9921250] C binds HNRNPK - Homo sapiens [Reaction:R-HSA-9920945] C binds DAXX - Homo sapiens [Reaction:R-HSA-9921290] C binds histones - Homo sapiens [Reaction:R-HSA-9921600] C binds DDX3X - Homo sapiens [BlackBoxEvent:R-HSA-9945181] C dimer gets exported from nucleus - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:5083567] protein localization to nucleoplasm
input	[Complex:R-DVI-9922232] C dimer [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9920141] Nuclear localization of dengue virus capsid protein is required for DAXX interaction and apoptosis [LiteratureReference:9945186] Importin-7-dependent nuclear translocation of the Flavivirus core protein is required for infectious virus production [LiteratureReference:208160] The importin beta/importin 7 heterodimer is a functional nuclear import receptor for histone H1 [LiteratureReference:9945165] Dengue Virus Capsid Protein Dynamics Reveals Spatially Heterogeneous Motion in Live-Infected-Cells [LiteratureReference:9945214] Kinetics of the association of dengue virus capsid protein with the granular component of nucleolus [LiteratureReference:9945396] Cytoplasmic retention of dengue virus capsid protein by metformin impairing nuclear transport
maxDepth	1
modified	[InstanceEdit:9970472] Stephan, Ralf, 2025-10-30
name	C dimer localizes to nucleus
negativePrecedingEvent	[NegativePrecedingEvent:9960007] Futile Cycle: C dimer gets exported from nucleus
output	[Complex:R-DVI-9922241] C dimer [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9922227] C forms a dimer - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
regulatedBy	[Requirement:9945180] Requirement by 'IPO7 [nuclear envelope]' [NegativeRegulation:9945393] Negative regulation by 'metformin [cytosol]'
regulationReference	[RegulationReference:9945172] Requirement by 'IPO7 [nuclear envelope]' Importin-7-dependent nuclear translocation of the Flavivirus core protein is required for infectious virus production [RegulationReference:9945395] Negative regulation by 'Metformin [cytosol]' Cytoplasmic retention of dengue virus capsid protein by metformin impairing nuclear transport
relatedSpecies	[Species:3244621] Dengue virus type 2
releaseDate	2025-12-08
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9966332] Mansur, Daniel Santos, 2025-09-18 [InstanceEdit:9970439] Roque Ascen��o, Fernando, 2025-10-29
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9919944
summation	[Summation:9920206] Dengue virus capsid protein (C) localizes to the nucleus in ...

Referrals

(precedingEvent)	[Reaction:R-HSA-9921250] C binds HNRNPK [Reaction:R-HSA-9920945] C binds DAXX [Reaction:R-HSA-9921290] C binds histones [Reaction:R-HSA-9921600] C binds DDX3X [BlackBoxEvent:R-HSA-9945181] C dimer gets exported from nucleus
(hasEvent)	[Pathway:R-HSA-9918432] Maturation of DENV proteins